<i>Escherichia coli</i> Infections

Makvana, Sejal; Krilov, Leonard R.

doi:10.1542/pir.36.4.167

Cited by 33 publications

(14 citation statements)

References 5 publications

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“…Escherichia coli are gram-negative bacilli of the Enterobacteriaceae family. Most strains are non-pathogenic; but some acquire invasive or enterotoxin-encoding factors, becoming virulent (Makvana & Krilov, 2015). These strains are the main causes of uncomplicated UTI, followed by Proteus spp., Klebsiella spp., and other Enterobacteriaceae.…”

Section: Resultsmentioning

confidence: 99%

Etiological and susceptibility profile of microorganisms causing urinary tract infection in pregnant women in the city of Palmas, Brazil

Campos

Vieira²,

Ramos³

et al. 2022

RSD

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Urinary tract infections (UTIs) are inflammatory pathologies resulting from the multiplication of microorganisms in the urinary tract. The risk group includes pregnant women, due to physiological changes caused by pregnancy, and such conditions are related to a greater risk of maternal-fetal complications. Treatment is based on the most likely etiology and should consider microbial sensitivity to antimicrobials, given the increasing emergence of resistance. Given the need to monitor the pathogenic epidemiology and its susceptibility, the study aims to determine the etiological and susceptibility profile of the microorganisms that cause UTI in pregnant women in the city of Palmas, Brazil. This is a descriptive observational study, based on the exploration of data made available by the clinical analysis laboratory of the Dona Regina Hospital and Maternity, located in Palmas. Urine culture and antibiogram results of pregnant women attended over a 12-month period (July/2021 - June/2022) were evaluated. The project was registered on Plataforma Brasil, for appreciation and analysis by the CEP/UFT, thus being adequate to the current regulations. It was found that the etiology of infections was predominantly associated with Escherichia coli (34.75%) and Enterococcus faecalis (23.73%). The drugs with the highest resistance rate were ampicillin (53.47%) and sulfamethoxazole with trimethoprim (41.56%); nitrofurantoin had the lowest rate (3.39%). It is concluded that the etiological profile corresponds to bacteria colonizing the gastrointestinal tract, which have some degree of resistance, especially to ampicillin, and have considerable sensitivity to nitrofurantoin.

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Section: Resultsmentioning

confidence: 99%

Etiological and susceptibility profile of microorganisms causing urinary tract infection in pregnant women in the city of Palmas, Brazil

Campos

Vieira²,

Ramos³

et al. 2022

RSD

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“…In contrast to other studies, the P. aeruginosa strain was isolated from domestic washing machines [23] and therefore represented a real-life germ. Furthermore, these bacteria cause many diseases, such as hospital acquired pneumonia, nosocomial bloodstream infections, diarrheal infections, meningitis, wound infections, and septicemia [24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Bacterial Biofilm Formation on Nano-Copper Added PLA Suited for 3D Printed Face Masks

et al. 2022

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The COVID-19 Pandemic leads to an increased worldwide demand for personal protection equipment in the medical field, such as face masks. New approaches to satisfy this demand have been developed, and one example is the use of 3D printing face masks. The reusable 3D printed mask may also have a positive effect on the environment due to decreased littering. However, the microbial load on the 3D printed objects is often disregarded. Here we analyze the biofilm formation of Pseudomonas aeruginosa, Staphylococcus aureus, and Escherichia coli on suspected antimicrobial Plactive™ PLA 3D printing filaments and non-antimicrobial Giantarm™ PLA. To characterize the biofilm-forming potential scanning electron microscopy (SEM), Confocal scanning electron microscopy (CLSM) and colony-forming unit assays (CFU) were performed. Attached cells could be observed on all tested 3D printing materials. Gram-negative strains P. aeruginosa and E. coli reveal a strong uniform growth independent of the tested 3D filament (for P. aeruginosa even with stressed induced growth reaction by Plactive™). Only Gram-positive S. aureus shows strong growth reduction on Plactive™. These results suggest that the postulated antimicrobial Plactive™ PLA does not affect Gram-negative bacteria species. These results indicate that reusable masks, while better for our environment, may pose another health risk.

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“…Escherichia coli is a Gram-negative, rod-shaped, lactose fermenting bacteria of the Enterobacteriaceae family [ 1 ]. It is responsible for a wide range of nosocomial and community-acquired infections [ 1 ]. Antibiotic resistance in E. coli has been increasing worldwide at an alarming rate [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Cefixime and cefixime-clavulanate for screening and confirmation of extended-spectrum beta-lactamases in Escherichia coli

Al‐Akchar

Albalawi

Shalabi

et al. 2022

Ann Clin Microbiol Antimicrob

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Introduction Detection of Extended-Spectrum Beta-Lactamases (ESBLs) depends on screening for resistance to certain cephalosporins, confirmation with selective ESBL inhibitors, and ESBL genes detection. New tests are required for accurate ESBL detection. Aims To test the ability of cefixime (CFM) and cefixime-amoxicillin/clavulanate (CFM-AMC) as a screening and confirmatory test for ESBL identification. Methods 246 clinical isolates of Escherichia coli were tested by an ESBL screening test, a double-disk synergy test (DDST), a disk replacement test, the Vitek 2 ESBL test, and an ESBL genes test by PCR. CFM ESBL Screening was performed by disk diffusion, while CFM-AMC confirmation was performed by DDST and a disk replacement test. Results 246 E. coli clinical isolates from two referral hospitals were collected over 2 years. The mean age ± standard deviation of patients was 43.8 ± 27.7 years and 76.8% were females. Resistance rates to penicillins, first, second, and third generation cephalosporins, and monobactams were very high at 97%, 84%, 100% and 97%, respectively. ESBL screening was positive in 81.3% of isolates, DDST was positive in 74.8%, disk replacement was positive in 79%, Vitek 2 ESBL test was positive in 67.3%, and ESBL genes were detected in 85.8% of isolates (CTX-M 75%, TEM 42.5%, SHV 4.6%). Compared to genotyping, screening with CFM achieved 87.7% sensitivity and 64.7% specificity. CFM-AMC DDST achieved 75.8% sensitivity and 75.4% specificity, and CFM-AMC disk replacement had 73% sensitivity and 70% specificity. Conclusions High prevalence of ESBLs was noted among E. coli isolates, dominated by CTX-M genotype. ESBL screening and confirmation using CFM and CFM-AMC is a new and accurate method for ESBLs detection.

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Escherichia coli Infections

Cited by 33 publications

References 5 publications

Etiological and susceptibility profile of microorganisms causing urinary tract infection in pregnant women in the city of Palmas, Brazil

Etiological and susceptibility profile of microorganisms causing urinary tract infection in pregnant women in the city of Palmas, Brazil

Bacterial Biofilm Formation on Nano-Copper Added PLA Suited for 3D Printed Face Masks

Cefixime and cefixime-clavulanate for screening and confirmation of extended-spectrum beta-lactamases in Escherichia coli

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