<i>Escherichia coli</i>-Based Biophotonic Waveguides

Xin, Hongbao; Li, Yayi; Liu, Xiaoshuai; Li, Baojun

doi:10.1021/nl401870d

Cited by 100 publications

(88 citation statements)

References 17 publications

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“…Many hydrogels are amenable to cell encapsulation which can then be used for light-mediated sensing or drug release [4,8]. Other research into biocompatible optical waveguides have utilized a variety of other materials including cellulose [9], silicone [10], agarose [8], and even bacterial cells [11], but due to high propagation losses, these materials have not seen rapid adoption.…”

Section: Introductionmentioning

confidence: 99%

Biocompatible silk step-index optical waveguides

Applegate¹,

Perotto²,

Kaplan³

et al. 2015

Biomed. Opt. Express

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Biocompatible optical waveguides were constructed entirely of silk fibroin. A silk film (n=1.54) was encapsulated within a silk hydrogel (n=1.34) to form a robust and biocompatible waveguide. Such waveguides were made using only biologically and environmentally friendly materials without the use of harsh solvents. Light was coupled into the silk waveguides by direct incorporation of a glass optical fiber. These waveguides are extremely flexible, and strong enough to survive handling and manipulation. Cutback measurements showed propagation losses of approximately 2 dB/cm. The silk waveguides were found to be capable of guiding light through biological tissue. #246610Received 23

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Section: Introductionmentioning

confidence: 99%

Biocompatible silk step-index optical waveguides

Applegate¹,

Perotto²,

Kaplan³

et al. 2015

Biomed. Opt. Express

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“…It has been demonstrated that a linear array of Escherichia coli aligned by optical forces could guide light [135]. Although bacteria would not be considered applicable to implantable devices, this work suggests the possibility of forming an optical waveguide in situ inside biological tissue by self-assembly of human cells or biocompatible particles.…”

Section: Bio-derived Materials Waveguidesmentioning

confidence: 96%

Toward biomaterial-based implantable photonic devices

et al. 2017

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Optical technologies are essential for the rapid and efficient delivery of health care to patients. Efforts have begun to implement these technologies in miniature devices that are implantable in patients for continuous or chronic uses. In this review, we discuss guidelines for biomaterials suitable for use in vivo. Basic optical functions such as focusing, reflection, and diffraction have been realized with biopolymers. Biocompatible optical fibers can deliver sensing or therapeutic-inducing light into tissues and enable optical communications with implanted photonic devices. Wirelessly powered, light-emitting diodes (LEDs) and miniature lasers made of biocompatible materials may offer new approaches in optical sensing and therapy. Advances in biotechnologies, such as optogenetics, enable more sophisticated photonic devices with a high level of integration with neurological or physiological circuits. With further innovations and translational development, implantable photonic devices offer a pathway to improve health monitoring, diagnostics, and light-activated therapies.

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“…To date, various optical waveguides have been fabricated using natural materials such as silk [34], cellulose [46] and bacteria cells [47]. For example, bio-derived cellulose polymers can be thermally drawn to form a core-cladding fiber structure, with some cellulose powders in between to form a hollow channel for potential drug delivery [46].…”

Section: Materials and Synthesismentioning

confidence: 99%

“…These cellulose fibers are fully dissolved after 1-day immersion in aqueous solutions and during the dissolution, the light transmittance increases with water intake. Optical waveguides can also be formed from bacterial cells (e.g., Escherichia coli, propagation loss ~0.23 dB/μm [47]), and their optical losses are needed to be further reduced for practical uses.…”

Section: Materials and Synthesismentioning

confidence: 99%

Biocompatible and Implantable Optical Fibers and Waveguides for Biomedicine

et al. 2018

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Optical fibers and waveguides in general effectively control and modulate light propagation, and these tools have been extensively used in communication, lighting and sensing. Recently, they have received increasing attention in biomedical applications. By delivering light into deep tissue via these devices, novel applications including biological sensing, stimulation and therapy can be realized. Therefore, implantable fibers and waveguides in biocompatible formats with versatile functionalities are highly desirable. In this review, we provide an overview of recent progress in the exploration of advanced optical fibers and waveguides for biomedical applications. Specifically, we highlight novel materials design and fabrication strategies to form implantable fibers and waveguides. Furthermore, their applications in various biomedical fields such as light therapy, optogenetics, fluorescence sensing and imaging are discussed. We believe that these newly developed fiber and waveguide based devices play a crucial role in advanced optical biointerfaces.

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Escherichia coli-Based Biophotonic Waveguides

Cited by 100 publications

References 17 publications

Biocompatible silk step-index optical waveguides

Biocompatible silk step-index optical waveguides

Toward biomaterial-based implantable photonic devices

Biocompatible and Implantable Optical Fibers and Waveguides for Biomedicine

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