eNOS haplotypes associated with gestational hypertension or preeclampsia

Abstract

These findings suggest a contribution of eNOS haplotypes to the development of hypertensive disorders of pregnancy that is obscured when specific eNOS genotypes alone are considered.

Maternal iNOS genetic polymorphisms and hypertensive disorders of pregnancy

“…Our findings are relevant because the search for genetic markers associated with HDP may allow early detection of increased susceptibility to disease conditions associated with increased morbility and mortality. 10,26,27 Abbreviations: CI, confidence interval; NS, not significant; OR, odds ratio.…”

“…[6][7][8] However, other mechanisms involving altered formation of nitric oxide (NO) have been implicated in HDP. 4,[9][10][11][12][13] In fact, there is now important evidence that impaired endothelial-derived NO bioavailability contributes to HDP. 4,[9][10][11][12][13] NO is synthesized from L-arginine by at least three different nitric oxide synthases (NOS): neuronal, endothelial and inducible NOS, respectively.…”

“…15 This reaction may be favored by increased iNOS expression because this enzyme produces huge amounts of NO, thus possibly contributing to PE. 16 However, while there is evidence that genetic polymorphisms commonly found in the eNOS gene may affect the susceptibility to HDP, 10,11,13 no previous study has examined whether genetic polymorphisms in the iNOS gene are associated with HDP in a relatively large number of patients, even though there is a pilot study implicating iNOS polymorphisms in PE. 17 This is an important hypothesis to be tested, especially because increased vascular iNOS expression and activity has been implicated in hypertension.…”

Vitamin D receptor polymorphisms in hypertensive disorders of pregnancy

“…We studied a total of 529 pregnant (213 healthy women with uncomplicated pregnancies-HP group, 154 women with gestational hypertension-GH group, and 162 women with preeclampsia-PE group). Hypertensive disorders were defined in accordance with the NHBPEP (National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy) [21]. GH was defined as pregnancy-induced hypertension (C140 mmHg systolic or C90 mmHg diastolic blood pressure on 2 or more measurements at least 6 h apart) in a woman after 20 weeks of gestation, and returning to normal by 12 weeks post-partum [24].…”

“…Three common VDR-SNPs (FokI, ApaI and BsmI) have been extensively investigated and associated with several diseases [9,[15][16][17][18][19][20]. However, although there is evidence for a genetic contribution to hypertensive disorders of pregnancy [21][22][23], no previous study has examined whether VDR polymorphisms affect the susceptibility to such disorders of pregnancy. In this study, we examined whether three VDR polymorphisms (FokI, ApaI and BsmI) are associated with PE or GH.…”