Emblica officinalisAmeliorates Alcohol-Induced Brain Mitochondrial Dysfunction in Rats

Abstract

The fruit of Emblica officinalis has been used in the Ayurvedic system of medicine for the treatment of different ailments and is also an ingredient of various traditional medicinal herbal formulations in India and other countries. To investigate the protective effect of Emblica officinalis fruit extract (EFE) against alcohol-induced brain mitochondrial dysfunction, male Wistar rats were orally administered 20% alcohol (5 g/kg of body weight/day) and EFE (250 mg/kg of body weight/day) for 60 days. Alcohol-treated rats showed significantly lowered activities of mitochondrial antioxidant enzymes (superoxide dismutase and glutathione peroxidase) and reduced glutathione compared with those of experimental control rats. Furthermore, alcohol feeding lowered the activities of NADH dehydrogenase, succinate dehydrogenase (SDH), and cytochrome c oxidase and the content of cytochromes followed by increased levels of nitric oxide (NO), thiobarbituric acid-reactive substances, and protein carbonyls. No significant change was observed in membrane potential. Administration of EFE to alcohol-treated rats, lowered the levels of NO, protein carbonyls, and lipid peroxidation and elevated the activities of the antioxidant enzymes SDH, NADH dehydrogenase, and cytochrome c oxidase and the content of cytochromes. The active tannoid principles present in EFE with its antioxidant as well as NO scavenging properties might have contributed to the observed protection against alcohol-induced brain mitochondrial dysfunction.

Use of certain herbal preparations in broiler feeds - A review

“…On other hand concentration of glucose in gelatin (kasahara), alleviate asthma (svasahara), strengthen results in high osmotic pressure that protects skin from the heart (hrdaya), benefit the eyes (chakshushya), stimulate hair growth (romasanjana), enliven the body live bacteria. Aloe vera includes antrokinone chemicals (jivaniya), and enhance intellect (medhya) [66,67].…”

Effects of amla on constipation

“…[11] Amla is the most concentrated form of Vitamin C found in the plant kingdom, and when the whole fruit is used rather than an active ingredient, the Vitamin C is easily assimilated by the human body. [15] Other uses  In treatment of scurvy [15]  Useful in treatment of mouth ulcers [16]  Balances stomach acids [11]  Enhances food absorption [16]  Nourishes the brain and mental functioning  Helps the urinary system [17]  Good for the skin [16]  Promotes healthier hair [11]  Diarrhoea [11]  Act as a body coolant [16] A normal pattern of stool evacuation is thought to be a sign of health in children all ages. Especially during the first months of life, parents pay close attention, characteristics of their children's defecation from what is thought by any family member to be normal for children may trigger a call to the nurse or a visit to the paediatrician.…”

“…It strengthens the [11] Amla is rich in vitamin c which is very important in the absorption of iron which helps the people suffering from anemia. [14] Amla is rich in Vitamin C and helps control blood pressure.. Triphala, a combination of amla and two other herbs is an excellent Amla is the most Vitamin C found in the plant kingdom, and when the whole fruit is used rather than an active ingredient, the Vitamin C is easily assimilated by the human [16] Nourishes the brain and mental functioning [17] of stool evacuation is thought to be a sign of health in children all ages. Especially during the first months frequency and characteristics of their children's defecation.…”

Ethno Medicinal Studies on Kurumba Community for the Treatment of Gastro-intestinal Disorders, Niligiri District, Tamil Nadu, India

“…Pharmacodynamic uses: Anti inflammatory and anti pyretic (Dhale and Mogle et al, 2012), Cancer chemopreventive activity (Singh et al, 2011), A wide range of phytochemical components including terpenoids, alkaloids, flavnoids and tannins have shown to posses' useful biologically (Kim et al, 2005, Arora et al, 2003, Eliminating toxins from the body (Tasduq et al, 2005), Supports nervous system and strengthens the senses (Reddy et al, 2011) Phyllanthus amarus (Kassuya et al, 2006), Antitumour and anticarcinogenic (Rajeshkumar et al, 2002), Anti-diarrhoeal and gastro-intestinal potentials (Odetola et al, 2000).…”