<i>Ehrlichia muris</i> Infection in a Dog from Minnesota

Hegarty, Barbara C.; Maggi, Ricardo G.; Koskinen, Pertti; Beall, Melissa J.; Eberts, Matthew D.; Chandrashekar, R.; Breitschwerdt, Edward B.

doi:10.1111/j.1939-1676.2012.00968.x

Cited by 38 publications

(26 citation statements)

References 13 publications

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“…The disease in humans is similar to that caused by A. phagocytophilum (see next section) with all patients having fever, malaise, headache, and lymphopenia and all recovered fully after treatment with doxycycline (Pritt et al 2011). Disease as a result of exposure to infected ticks has also been described in dogs (Hegarty et al 2012). Blacklegged ticks from Manitoba have been screened for this pathogen but infected specimens were not detected; however, a single female Ixodes muris was infected with a variant of the E. muris-like agent (L.R.L., personal observation).…”

Section: Tick-borne Relapsing Fevermentioning

confidence: 65%

The Biological Survey of Canada: A Personal History

Danks¹

2017

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Section: Tick-borne Relapsing Fevermentioning

confidence: 65%

The Biological Survey of Canada: A Personal History

Danks¹

2017

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“…However, specific serologic assays for the PME agent are not available, and other novel, closely related organisms also likely cycle in nature; exposure to the PME agent or a related organism may well be responsible for the antibody reactivity seen. For example, serologic reactivity in dogs in Minnesota and Wisconsin to a p30-based assay was likely due to infection with a novel E. muris-like (EML) agent (Bowman et al 2009, Hegarty et al 2012). The EML agent may infect horses as well but is not known to circulate in Oklahoma.…”

Section: Discussionmentioning

confidence: 99%

Antibodies Reactive toEhrlichiaspp. Are Common in Oklahoma Horses

CarmichaelRobert

DuellJason

HolbrookTodd

et al. 2014

Vector-Borne and Zoonotic Diseases

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Tick infestations and infection with tick-borne agents are commonly recognized in horses in North America, but equine infection with true Ehrlichia spp. has not been described. To determine the degree to which horses in the south-central United States are naturally exposed to and infected with tick-borne disease agents, serum samples were collected at random (n=240) or from horses with active tick infestations (n=73) and tested by immunofluorescence antibody assay (IFA) and/or enzyme-linked immunosorbent assay (ELISA) for evidence of antibodies reactive to Ehrlichia spp., Anaplasma spp., and Borrelia burgdorferi. Positive samples were further evaluated by species-specific serology for antibodies reactive to E. canis and E. chaffeensis, and whole blood samples were tested by PCR for evidence of infection with E. canis, E. chaffeensis, E. ewingii, and an E. ruminantium-like organism referred to as the Panola Mountain Ehrlichia. Antibodies reactive to Ehrlichia spp. were identified in 8.75% (21/240) of the randomly acquired samples and 24.7% (18/73) of the serum samples from tick-infested horses, but species-specific ELISA and PCR failed to confirm exposure to or infection with any known Ehrlichia spp. Antibodies to Anaplasma spp. (5/313; 1.6%) and B. burgdorferi (3/313; 1.0%) were uncommon. These data suggest that horses in the south-central United States are likely exposed to a novel Ehrlichia sp. Further research is needed to identify the etiologic agent responsible for the serologic activity seen and to determine the clinical significance, if any, of this finding.

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“…Interestingly, since these studies were reported, at least one case of clinical illness associated with Ehrlichia muris infection has been documented in a dog living in Minnesota -returning us once again to the first paradigm discussed in this review, to expect the unexpected [73].…”

Section: Paradigm 4: Cvbd Veterinarians and Public Healthmentioning

confidence: 89%

It shouldn’t happen to a dog … or a veterinarian: clinical paradigms for canine vector-borne diseases

Irwin

2014

Trends in Parasitology

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Keywords:Canine, vector-borne diseases, zoonosis, emerging disease, diagnosis, travel medicine, compliance AbstractCanine vector-borne diseases (CVBDs) comprise a diverse group of viral, bacterial, protozoal, and helminth pathogens, transmitted predominantly by ticks and fleas, and cause significant health problems for dogs worldwide. Growing numbers of reports indicate that CVBDs are emerging in regions where they previously did not exist and this, combined with pathogens that are inherently difficult to detect, is providing companion animal veterinarians with some significant diagnostic challenges. This review discusses six paradigms concerning the diagnosis, treatment, prevention, and zoonotic implications of CVBDs from a veterinary clinical perspective. Veterinarians are the key professionals at the companion animal: human interface. Not only do they provide the traditional medical and surgical services for pets, their training in the disciplines of parasitology, microbiology, epidemiology, and public health place them in a unique position to provide advice about matters pertaining to vector-borne diseases. Despite this, emerging canine vector-borne diseases (CVBDs) pose a number of significant and complex challenges for veterinarians in clinical practice whose responsibility it is to diagnose and treat these companion animals, while at the same time remaining mindful of the potential for disease transmission to the owners and other people living in close proximity, as well as to other susceptible animals [5]. As will be discussed here, many CVBDs are caused by organisms that are inherently difficult to detect, frequently cause nebulous clinical signs in their canine hosts, and are sometimes zoonotic. In addition, the rapid progress of scientific research in this area itself poses further challenges of how best to distil and disseminate this knowledge to busy veterinary practitioners worldwide at a time when every aspect of clinical practice is becoming more complex. How should practitioners keep current with information in this area so that they can provide appropriate evidence-based advice to their clients?

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Ehrlichia muris Infection in a Dog from Minnesota

Cited by 38 publications

References 13 publications

The Biological Survey of Canada: A Personal History

The Biological Survey of Canada: A Personal History

Antibodies Reactive toEhrlichiaspp. Are Common in Oklahoma Horses

It shouldn’t happen to a dog … or a veterinarian: clinical paradigms for canine vector-borne diseases

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