<i>Effect of Sodium Thiopental on Circulatory Response to Positive Pressure Inflation of Lung</i>

Price, Henry L.; Conner, Eugene H.; Elder, J.D.; Dripps, Robert D.

doi:10.1152/jappl.1952.4.8.629

Cited by 22 publications

(7 citation statements)

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“…Thiobarbiturates, especially thiopental sodium, depress the sympathetic system (1, 32), stimulate the sympathetic system (18) and are vagolytic in action ( 6 ) . The vasoconstriction following thiopental anaesthesia in dogs and man has been ascribed to stimulation of pressoreceptors (19), increased peripheral resistance due to baroreceptors activation (17, 19,27) or t9 local release of catecholamines near vascular smooth muscles (4). In the present study, tachycardia, hypotension and vascular pooling do not suggest stimulation of the sympathetic system.…”

Section: Discussionmentioning

confidence: 99%

Haemodynamics, Blood Gas and Metabolic Alterations During Thiopental Anaesthesia in Buffaloes

Singh

Mirakhur

Sobti

et al. 1980

Zentralblatt für Veterinärmedizin Reihe A

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Summary Seven clinically healthy buffalo calves (62–194 kg.) were anaesthetized with 5% thiopental sodium (1 g./100 kg.) to evaluate the effects of this agent in this species. There was significant tachycardia without any appreciable abnormality in the electrocardiogram. Anaesthesia was associated with moderate hypotension and a significant gradual decline in central venous pressure. The variations in arterial pCO2 were not consistent. Mild to moderate metabolic acidosis was observed in all the animals and in five calves this was associated with very mild to moderate respiratory acidosis. Moderate to severe arterial hypoxaemia due to fall in pO2 and desaturation of haemoglobin was a consistent feature in all the animals. Haemoglobin‐oxygen affinity was increased. Alterations in packed cell volume, oxyhaemoglobin, total proteins and albumin were not appreciable. Hypoglycaemia was found 24 hours after induction. There was evidence of parasympathetic depression, vascular pooling, hypokinetic hypoxia, alveolar hypofunction in two animals and ventilation‐to‐perfusion abnormalities in five calves. There was no evidence of reduced or defective oxygen consumption. Zusammenfassung Änderungen der Hämodynamik, der Blutgase und des Metabolismus während der Thiopental‐Narkose bei Büffeln Sieben klinisch gesunde Büffelkälber (62–194 kg Körpergewicht) wurden mit Thiopental‐Natrium (5% Lösung, 1 g/100 kg Körpergewicht) narkotisiert und dessen Wirkungen untersucht. Ergebnisse: Signifikante Tachykardie ohne wesentliche EKG‐Abnormitäten. Leichte Abnahme des arteriellen Blutdruckes. Signifikante Senkung des zentralvenösen Druckes. Kein einheitliches Verhalten des arteriellen pCO2. Bei allen Tieren mäßige metabolische Azidose. Mäßige bis schwere arterielle Hypoxämie infolge Senkung des pO2 und O2‐Untersättigung des Hämoglobins bei allen Tieren. Erhöhung der O2‐Affinität des Hämoglobins. Keine nennenswerten Veränderungen des Hämatokritwertes, des Oxyhämoglobins, des Totalproteins und Albumins. Hypoglykämie 24 Stunden nach der Narkose. Im weiteren wurden bei 2 Tieren Symptome einer parasympathischen Tonussenkung und Blutstauungen sowie einer hypokinetischen Hypoxie und alveolären Hypofunktion beobachtet. Bei 5 Tieren traten Abnormitäten des pulmonalen Ventilations‐Perfusions‐Verhältnisses auf. Hinweise auf eine reduzierte oder gestörte O2‐Konsumation wurden nicht festgestellt. Résumé Modifications de l'hémodynamique, des gaz sanguins et du métabolisme lors d'une narcose au thiopental chez des buffles Sept veaux de buffle cliniquement sains (62–194 kg de poids) ont subi une narcose au sodium de thiopental (solution à 5%, 1 g/100 kg de poids) dont les actions ont été examinées. Résultats: Une tachycardie significative sans anomalies manifestes de ECG. Une légère diminution de la pression sanguine artérielle et une diminution significative de la pression veineuse centrale. Aucun comportement homogène du pCO2 artériel. Une acidose métabolique moyenne chez tous les animaux. Une hypoxémie artérielle moyenne à grave à la suite d'un abaissemen...

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Section: Discussionmentioning

confidence: 99%

Haemodynamics, Blood Gas and Metabolic Alterations During Thiopental Anaesthesia in Buffaloes

Singh

Mirakhur

Sobti

et al. 1980

Zentralblatt für Veterinärmedizin Reihe A

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“…Marked variations of respiratory exchange (24), therefore, can be excluded as a factor in causing lowered cardiac output and lowered intrathoracic blood volume or in concealing changes in the effective auricular filling pressure. Since the central venous and left auricular pressures (18,25) are not elevated during thiopental anesthesia, it is reasonable to state that the decrease in cardiac output is not the result of depression of the heart as a pump. (26), and cerebral metabolism is decreased during thiopental anesthesia (27,28).…”

Section: Discussionmentioning

confidence: 99%

Hemodynamic Changes During Thiopental Anesthesia in Humans: Cardiac Output, Stroke Volume, Total Peripheral Resistance, and Intrathoracic Blood Volume 12

Etsten¹,

Li²

1955

J. Clin. Invest.

106

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“…There are, however, good reasons to believe that such a conclusion is not fully warranted since such reflexes are difficult to demon strate in anaesthetized animals. For exam ple, in cats halothane almost totally abol ished the pressor response to carotid occlu sion [25], while in dogs there was a greater than 50% reduction in the response to ca rotid sinus hypotension [26], Barbiturate anaesthesia caused a 60% depression of the response to carotid occlusion in dogs and in man abolished the vasomotor response to hypertension during lung inflation [27],…”

Section: Lymphomotor Reflexesmentioning

confidence: 99%

Lymphatic Innervation

McHale¹

1990

J Vasc Res

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Bovine mesenteric lymphatic vessels have nerves in their walls which in response to field stimulation cause an increase in freqency of spontaneous lymphatic contractions and this could be blocked by α-antagonists. When vessels were loaded with [³H]-noradrenaline, ³H-effiux was increased in response to field stimulation and this was potentiated by α₂-antagonists and depressed by α₂-agonists. Electrical activity in these vessels consisted of a single action potential which preceded each contraction. Mean resting potential was –61 mV ± 5.7 (SD). Stimulation of postsynaptic α-receptors caused a depolarization accompanied by a decrease in membrane conductance while β-receptor stimulation had the opposite effect. Lymphatic noradrenergic nerves appear to have a role in the living animal since stimulation of the sympathetic chain in anaesthetized sheep increased popliteal efferent lymph flow and this could be blocked by α-adrenergic blockers.

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Effect of Sodium Thiopental on Circulatory Response to Positive Pressure Inflation of Lung

Cited by 22 publications

References 0 publications

Haemodynamics, Blood Gas and Metabolic Alterations During Thiopental Anaesthesia in Buffaloes

Haemodynamics, Blood Gas and Metabolic Alterations During Thiopental Anaesthesia in Buffaloes

Hemodynamic Changes During Thiopental Anesthesia in Humans: Cardiac Output, Stroke Volume, Total Peripheral Resistance, and Intrathoracic Blood Volume 12

Lymphatic Innervation

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