(<i>E</i>)-2-[(1<i>H</i>-Imidazol-4-yl)methylidene]hydrazinecarbothioamide monohydrate

Benayad, H.; Louhibi, Samira; Boukli-Hacene, Leila; Roisnel, Thierry; Taleb, Mustapha

doi:10.1107/s1600536813022927

Cited by 4 publications

(4 citation statements)

References 6 publications

(8 reference statements)

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“…In Table 2, we give the selected interatomic distances and angle values. So, these bond lengths and angles agree very well with to those observed for similar thiosemicarbazones [39]. In the crystal, the stacking of molecules is in a zigzag shape along the b axis ( Figure 2).…”

Section: Crystal Structure Of Ligand L1supporting

confidence: 86%

New thiosemicarbazone Schiff base ligands: Synthesis, characterization, catecholase study and hemolytic activity

Nehar

Mahboub

Louhibi

et al. 2020

Journal of Molecular Structure

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Two novel thiosemicarbazones ligands have been synthesized and characterized by FT-IR, ESI-MS, 1 H NMR, and also by single-crystal X-ray diffraction for L1. The crystal structure shows that L1 molecules are planar and are connected via N-H-S and O-H-S interactions. The catecholase activity of is situ copper and cobalt complexes of this ligands has been investigated against 3,5-di-tert-butylcatechol. The progress of the oxidation reactions was closely monitored over time following the strong peak of 3,5-DTBC using UV-Vis. Oxidation rates were determined from the initial slope of absorbance vs. time plots, then analyzed by Michaelis-Menten equations. Catechol oxidation reactions were realized using different concentrations of copper and cobalt acetate and ligands (L/Cu: 1/1, 1/2, 2/1). The results show that all complexes were able to catalyze the oxidation of 3,5-DTBC. Acetate complexes have the highest activity. CuL1 and CoL1 complexes act as a catalyst and inhibitor. While copper and cobalt complexes obtained from ligand L2 illustrate concentration-independent oxidation activation. The hemolysis study performed by L1 increases as a function of its concentration. However, ligand L2 has no hemolytic effect.

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Section: Crystal Structure Of Ligand L1supporting

confidence: 86%

New thiosemicarbazone Schiff base ligands: Synthesis, characterization, catecholase study and hemolytic activity

Nehar

Mahboub

Louhibi

et al. 2020

Journal of Molecular Structure

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“…This planarity is due to electron delocalization along the cationic entity backbone. Bond lengths and angles are close to those observed for similar (methylidene)hydrazinecarbothioamide derivatives (Gangadharan et al, 2015;Joseph et al, 2004;Houari et al, 2013. )…”

Section: Structural Commentarysupporting

confidence: 83%

Synthesis and crystal structure of ((E)-{2-[(E)-(4-hydroxynaphthalen-1-yl)methylidene]hydrazin-1-yl}(methylsulfanyl)methylidene)azanium hydrogen sulfate monohydrate

Nehar¹,

Louhibi²,

Boukli-Hacene³

et al. 2016

Acta Cryst E

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“…Equimolar amounts of thiosemicarbazide (910 mg, 0.001 mol) and 4-imidazole carboxaldehyde (960 mg, 0.001 mol) were dissolved in 20 mL of ethanol:water (60:40, v:v) and refluxed for 7 h in an oil bath at 78 °C [18][19][20][21]. The solution was allowed to cool at room temperature and left for slow solvent evaporation.…”

Section: Synthesis Of 4-imidazolecarboxaldehyde Thiosemicarbazone (4-mentioning

confidence: 99%

Synthesis, characterization, and antimicrobial activity of 4-imidazolecarboxaldehyde thiosemicarbazone and its Pt(II) and Pd(II) complexes

et al. 2021

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Schiff bases are versatile ligands, synthesized via condensation of primary amines with carbonyl compounds. In this study, equimolar amounts of 4-imidazolecarboxaldehyde and thiosemicarbazide were combined and the Schiff base 4-imidazolecarboxaldehyde thiosemicarbazone was prepared as a new bidentate complexing agent. The synthesized ligand was reacted with palladium (II) and platinum (II) ions yielding air-stable complexes. For characterization purpose, infrared spectra, mass spectra, electronic spectra, thermal analysis, proton nuclear magnetic resonance and 13-carbon nuclear magnetic resonance spectra studies were carried out on the obtained complexes and ligand. The characterization data showed that the ligand acts as a bidentate coordinate to the metal ions through azomethine nitrogen and sulfur atoms. An in vitro antimicrobial investigation was also carried out for the free ligand and its metal complexes against four bacteria; Bacillus cereus, Staphylococcus aureus (Gram-positive), Escherichia coli and Salmonella typhimurium (Gram-negative) and one Fungi; Candida albicans, to assess their antimicrobial properties by disc diffusion technique. Antimicrobial activity of the prepared complexes showed higher activity than the free ligand.

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(E)-2-[(1H-Imidazol-4-yl)methylidene]hydrazinecarbothioamide monohydrate

Cited by 4 publications

References 6 publications

New thiosemicarbazone Schiff base ligands: Synthesis, characterization, catecholase study and hemolytic activity

New thiosemicarbazone Schiff base ligands: Synthesis, characterization, catecholase study and hemolytic activity

Synthesis and crystal structure of ((E)-{2-[(E)-(4-hydroxynaphthalen-1-yl)methylidene]hydrazin-1-yl}(methylsulfanyl)methylidene)azanium hydrogen sulfate monohydrate

Synthesis, characterization, and antimicrobial activity of 4-imidazolecarboxaldehyde thiosemicarbazone and its Pt(II) and Pd(II) complexes

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