<i>Drosophila odz</i> gene is required for multiple cell types in the compound retina

Kinel-Tahan, Yael; Weiss, H.-D.; Dgany, Orly; Levine, Anna; Wides, Ron

doi:10.1002/dvdy.21284

Cited by 21 publications

(17 citation statements)

References 46 publications

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“…Expression data, and subsequently odz disruption and clone data, show that odz is necessary for patterning in the eye (Levine et al, 1997b;Kinel-Tahan et al, 2007). Ten-a is expressed in eye discs (not shown) and its mutants also demonstrate a role in patterning of the eye.…”

Section: Semi-lethal Ten-a Mutants and Allelic Combinations Show Eye mentioning

confidence: 86%

RETRACTED: Drosophila Ten-a is a maternal pair-rule and patterning gene

Rakovitsky

Buganim

Swissa

et al. 2007

Mechanisms of Development

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The Ten-a gene of Drosophila melanogaster encodes several alternative variants of a full length member of the Odz/Tenm protein family. A number of Ten-a mutants created by inexact excisions of a resident P-element insertion are embryonic lethal, but show no pair-rule phenotype. In contrast, these mutants, and deficiencies removing Ten-a, do enhance the segmentation phenotype of a weak allele of the paralog gene odz (or Ten-m) to the odz amorphic phenotype. Germ line clone derived Ten-a(-) embryos display a pair-rule phenotype which phenocopies that of odz. Post segmentation eye patterning phenotypes of Ten-a mutants establish it as a pleiotropic patterning co-partner of odz.

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Section: Semi-lethal Ten-a Mutants and Allelic Combinations Show Eye mentioning

confidence: 86%

RETRACTED: Drosophila Ten-a is a maternal pair-rule and patterning gene

Rakovitsky

Buganim

Swissa

et al. 2007

Mechanisms of Development

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“…Mutation of the fly ten-m gene causes embryonic lethality due to the fusion of adjacent denticle belts (Baumgartner et al, 1994;Levine et al, 1994). Moreover, defects in the ventral nerve cord, cardiac cells and eye patterning are found in late ten-m mutant embryos (Levine et al, 1994;Kinel-Tahan et al, 2007). Similar defects in cuticle and eye development have been observed for the second Drosophila teneurin gene, ten-a (Rakovitsky et al, 2007).…”

Section: Introductionmentioning

confidence: 56%

Caenorhabditis elegansTeneurin,ten-1, Is Required for Gonadal and Pharyngeal Basement Membrane Integrity and Acts Redundantly with Integrinina-1and Dystroglycandgn-1

Trzebiatowska

Topf

Sauder

et al. 2008

MBoC

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The Caenorhabditis elegans teneurin ortholog, ten-1, plays an important role in gonad and pharynx development. We found that lack of TEN-1 does not affect germline proliferation but leads to local basement membrane deficiency and early gonad disruption. Teneurin is expressed in the somatic precursor cells of the gonad that appear to be crucial for gonad epithelialization and basement membrane integrity. Ten-1 null mutants also arrest as L1 larvae with malformed pharynges and disorganized pharyngeal basement membranes. The pleiotropic phenotype of ten-1 mutant worms is similar to defects found in basement membrane receptor mutants ina-1 and dgn-1 as well as in the mutants of the extracellular matrix component laminin, epi-1. We show that the ten-1 mutation is synthetic lethal with mutations of genes encoding basement membrane components and receptors due to pharyngeal or hypodermal defects. This indicates that TEN-1 could act redundantly with integrin INA-1, dystroglycan DGN-1, and laminin EPI-1 in C. elegans development. Moreover, ten-1 deletion sensitizes worms to loss of nidogen nid-1 causing a pharynx unattached phenotype in ten-1;nid-1 double mutants. We conclude that TEN-1 is important for basement membrane maintenance and/or adhesion in particular organs and affects the function of somatic gonad precursor cells.

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“…Unlike the differential expression across genotypes, there was little relationship among the magnitude of expression and the variability; highly expressed genes were equally likely to have high or low levels of variability (Figure 6, A and B). An example of differences across replicates can be observed in a plot of gene expression in Tenascin-major ( Ten-m ) (Figure 6D)—a gene with roles in eye morphogenesis, photoreceptor development, and synaptic growth (Kinel-Tahan et al 2007; Mosca et al 2012). The differences observed in Ten-m and the other differentially expressed genes across replicates suggest that latent plasticity in the transcriptome may exist whether environmental conditions are systematically altered or not.…”

Section: Resultsmentioning

confidence: 99%

Microenvironmental Gene Expression Plasticity Among IndividualDrosophila melanogaster

Lin

Chen

Oliver

et al. 2016

G3 Genes|Genomes|Genetics

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Differences in phenotype among genetically identical individuals exposed to the same environmental condition are often noted in genetic studies. Despite this commonplace observation, little is known about the causes of this variability, which has been termed microenvironmental plasticity. One possibility is that stochastic or technical sources of variance produce these differences. A second possibility is that this variation has a genetic component. We have explored gene expression robustness in the transcriptomes of 730 individual Drosophila melanogaster of 16 fixed genotypes, nine of which are infected with Wolbachia. Three replicates of flies were grown, controlling for food, day/night cycles, humidity, temperature, sex, mating status, social exposure, and circadian timing of RNA extraction. Despite the use of inbred genotypes, and carefully controlled experimental conditions, thousands of genes were differentially expressed, revealing a unique and dynamic transcriptional signature for each individual fly. We found that 23% of the transcriptome was differentially expressed among individuals, and that the variability in gene expression among individuals is influenced by genotype. This transcriptional variation originated from specific gene pathways, suggesting a plastic response to the microenvironment; but there was also evidence of gene expression differences due to stochastic fluctuations. These observations reveal previously unappreciated genetic sources of variability in gene expression among individuals, which has implications for complex trait genetics and precision medicine.

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Drosophila odz gene is required for multiple cell types in the compound retina

Cited by 21 publications

References 46 publications

RETRACTED: Drosophila Ten-a is a maternal pair-rule and patterning gene

RETRACTED: Drosophila Ten-a is a maternal pair-rule and patterning gene

Caenorhabditis elegansTeneurin,ten-1, Is Required for Gonadal and Pharyngeal Basement Membrane Integrity and Acts Redundantly with Integrinina-1and Dystroglycandgn-1

Microenvironmental Gene Expression Plasticity Among IndividualDrosophila melanogaster

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