<i>Drosophila melanogaster</i>as a model system for the evaluation of anti-aging compounds

Jafari, Mahvash

doi:10.4161/fly.4.3.11997

Cited by 44 publications

(35 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Third, the technique of genetic manipulation in Drosophila is now quite mature. There are a wide variety of transgenic flies available, which simplify the exploration for the targets [64]. Meanwhile, fly strains with longer life span are reported to have no reduction in metabolic rate [65].…”

Section: Drosophila and Other Models In Aging Researchmentioning

confidence: 99%

Biology of Ageing and Role of Dietary Antioxidants

Peng

Wang

Chen

et al. 2014

BioMed Research International

152

138

View full text Add to dashboard Cite

Interest in relationship between diet and ageing is growing. Research has shown that dietary calorie restriction and some antioxidants extend lifespan in various ageing models. On the one hand, oxygen is essential to aerobic organisms because it is a final electron acceptor in mitochondria. On the other hand, oxygen is harmful because it can continuously generate reactive oxygen species (ROS), which are believed to be the factors causing ageing of an organism. To remove these ROS in cells, aerobic organisms possess an antioxidant defense system which consists of a series of enzymes, namely, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR). In addition, dietary antioxidants including ascorbic acid, vitamin A, vitamin C, α-tocopherol, and plant flavonoids are also able to scavenge ROS in cells and therefore theoretically can extend the lifespan of organisms. In this connection, various antioxidants including tea catechins, theaflavins, apple polyphenols, black rice anthocyanins, and blueberry polyphenols have been shown to be capable of extending the lifespan of fruit flies. The purpose of this review is to brief the literature on modern biological theories of ageing and role of dietary antioxidants in ageing as well as underlying mechanisms by which antioxidants can prolong the lifespan with focus on fruit flies as an model.

show abstract

Section: Drosophila and Other Models In Aging Researchmentioning

confidence: 99%

Biology of Ageing and Role of Dietary Antioxidants

Peng

Wang

Chen

et al. 2014

BioMed Research International

152

138

View full text Add to dashboard Cite

show abstract

“…As early as 1948, the fruit fly was used to determine the biological effects of discrete chemical components of royal jelly, and to this end pantothenic acid was suggested to extend longevity of the fly (Gardner, 1948a, b). A recent review outlines the current strengths of the model and in particular sets out specific guidelines for evaluating the significance of chemical hits (Jafari, 2010). With the emergence of an increasing number of compounds shown to slow aging in C. elegans , D. melanogaster presents the opportunity to test whether the action of these compound on aging is species specific or is conserved.…”

Section: General Consideration When Conducting Experiments To Idenmentioning

confidence: 99%

Pharmacological lifespan extension of invertebrates

Lucanic

Lithgow

Alavez

2013

Ageing Research Reviews

View full text Add to dashboard Cite

There is considerable interest in identifying small, drug-like compounds that slow aging in multiple species, particularly in mammals. Such compounds may prove to be useful in treating and retarding age-related disease in humans. Just as invertebrate models have been essential in helping us understand the genetic pathways that control aging, these model organisms are also proving valuable in discovering chemical compounds that influence longevity. The nematode Caenorhabditis elegans (C. elegans) has numerous advantages for such studies including its short lifespan and has been exploited by a number of investigators to find compounds that impact aging. Here, we summarize the progress being made in identifying compounds that extend the lifespan of invertebrates, and introduce the challenges we face in translating this research into human therapies.

show abstract

“…A wide variety of mutants and transgenic strains, including inducible RNA interference (RNAi) lines, might sensitise the detection of the biological activity of compounds and lead to the identification of targets in vivo [9]. For example, wine-derived resveratrol ( trans -3,5,4′-trihydroxystilbene) was shown to extend the Drosophila lifespan, concomitantly with stimulation of Sir2 activation [10].…”

Section: Introductionmentioning

confidence: 99%

Pharmacological modulation of histone demethylase activity by a small molecule isolated from subcritical water extracts of Sasa senanensis leaves prolongs the lifespan of Drosophila melanogaster

Nakagawa-Yagi

Sato

Matsumoto

et al. 2012

BMC Complement Altern Med

View full text Add to dashboard Cite

BackgroundExtracts of Sasa senanensis Rehder are used in traditional Japanese medicine; however, little is known about the underlying mechanisms of their potential health benefits.MethodsS. senanensis leaves were extracted with subcritical water. An active small-molecule was isolated using reversed-phase high-performance liquid chromatography (HPLC), and identified as 3,4-dihydroxybenzaldehyde (protocatechuic aldehyde or PA). The effects of PA on the activity of histone demethylase, the Drosophila melanogaster lifespan and gene expression in Drosophila S2 cells were investigated.ResultsPA inhibited the activity of Jumonji domain-containing protein 2A (JMJD2A) histone demethylase in a dose-dependent manner with a half-maximal inhibitory concentration (IC50) of 11.6 μM. However, there was no effect on lysine-specific demethylase 1 (LSD1), histone deacetylase 1 (HDAC1) or HDAC8. PA significantly extended the lifespan of female, but not male, Drosophila. In Drosophila S2 cells, the eukaryotic translation initiation factor 4E binding protein (4E-BP) was up-regulated by PA exposure.ConclusionsOur findings provide insight into the possible relationship between the pharmacological modulation of histone demethylation and lifespan extension by PA; they might also be important in the development of alternative therapies for age-related disorders.

show abstract

Drosophila melanogasteras a model system for the evaluation of anti-aging compounds

Cited by 44 publications

References 31 publications

Biology of Ageing and Role of Dietary Antioxidants

Biology of Ageing and Role of Dietary Antioxidants

Pharmacological lifespan extension of invertebrates

Pharmacological modulation of histone demethylase activity by a small molecule isolated from subcritical water extracts of Sasa senanensis leaves prolongs the lifespan of Drosophila melanogaster

Contact Info

Product

Resources

About