<i>Determination of Human Body Surface Area From Height and Weight</i>

Sendroy, Julius; Cecchini, Louis P.

doi:10.1152/jappl.1954.7.1.1

Cited by 130 publications

(38 citation statements)

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“…Large number of formulae to estimate BSA from children's height and weight are used. 31,[36][37][38][39][40] Some formulae such as Dubois and Dubois 36 are estimated from a small number of patients and serious errors in its use have been described. 41 (3) The adult dosing is commonly used on an mg/kg basis.…”

Section: Discussionmentioning

confidence: 99%

I.V. busulfan in pediatrics: a novel dosing to improve safety/efficacy for hematopoietic progenitor cell transplantation recipients

Nguyen

Fuller

Lennon

et al. 2004

Bone Marrow Transplant

127

156

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Summary:A retrospective population pharmacokinetic (PPK) analysis was performed in 24 pediatric patients (PEDS) (0.45-16.7 years old) receiving i.v. busulfan/cyclophosphamide (i.v. Bu/Cy 4) regimen prior to allogeneic hematopoietic stem cell transplantation. I.V. Bu doses were given as a 2-hour infusion every 6 h over 4 days. Initial dosing of i.v. Bu was 1 mg/kg for children p4 years old and 0.8 mg/kg for patients 44 years old. Bu plasma concentrations at doses 1, 9 and 13 were analyzed through a multivariate NONMEM analysis. A close log-linear relationship between body weight (BW) and i.v. Bu clearance was demonstrated with no further age-dependency or gender effect. The interpatient coefficient of variation (CV) in Bu clearance significantly decreased from 56% (covariate-free model) to 19% (BW covariate model) and reproducible i.v. Bu exposure between doses was illustrated (intraindividual CV ¼ 9%). Based on the PPK model, a novel Bu dosing regimen (ie: doses in mg/kg adjusted to discrete weight categories) for a better AUC targeting was developed by simulation on 1000 patients. Age-based dosing was demonstrated not to be clinically relevant with i.v. Bu. Use of the new BW-based dosing appears to be more appropriate for the PEDS.

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Section: Discussionmentioning

confidence: 99%

I.V. busulfan in pediatrics: a novel dosing to improve safety/efficacy for hematopoietic progenitor cell transplantation recipients

Nguyen

Fuller

Lennon

et al. 2004

Bone Marrow Transplant

127

156

View full text Add to dashboard Cite

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“…There are a large number of publications describing formulae and/or nomograms to estimate BSA from patient height and weight (DuBois and DuBois, 1916;Boyd, 1935;Sendroy and Cechini, 1952;Haycock and Schwarz, 1978;George and Gehan, 1979;Mosteller, 1987). Many of these formulae are derived by painstaking direct measurement of BSA using a variety of techniques, but often in a small number of subjects.…”

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confidence: 99%

Body surface area estimation in children using weight alone: application in paediatric oncology

et al. 2001

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The majority of chemotherapy regimens and trials specify doses of cytotoxic drugs normalized to body surface area. Estimation of BSA in paediatric patients is particularly problematic, as conventional nomograms require accurate determination of both height and weight. The chemotherapy standards group of the UKCCSG (United Kingdom Children's Cancer Study Group) has evaluated a method for calculation of body surface area (BSA) estimation, based solely on patient weight. In comparison with BSA estimations using 2 commonly used methods, which require both weight and height measurements, deviation in the estimate of BSA was less than 10%. This method may be extended to the dosing of chemotherapeutic agents in infants of body weight less than 10 kg, with appropriate recommendations for dose modification. Until better correlates of drug clearance, such as GFR for carboplatin, are identified BSA is used to standardize doses for most chemotherapeutic agents. The formula presented here provides a more robust and reliable method of calculation of BSA from weight alone. Although this approach has been shown to be equivalent to other currently used methods, care should be taken extending this calculation of BSA to children less than 10 kg, to obese patients and to those with cachexia. © 2001 Cancer Research Campaign http://www.bjcancer.com

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“…I n spitc of common usage, the validity of the cardiac index has been challenged [2, 27, 281 and defended [3,5,13, 291 rcpcatcclly in recent years. 'Thc bcst available surface area estimate, namely the nomogram developed by SENDROY and CI~CCHINI [25], was applied to our data. Surfacc arca did not offer a significant improvement in predicting normality.…”

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confidence: 99%

Hemodynamic Findings in Normal Children

et al. 1967

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ExtractWe have studied cardiac function and dynamics in 29 apparently normal children under 20 years of age. Table I lists the values obtained for intracardiac and great vessel pressures. There was no correlation of these pressures with either age or increasing body size. Except for the possibility that our data is inadequate for patients under one week of age, these pressures as well as the ratio between pulmonary artery mean to systemic artery mean (fig. l ) , appear to be constant throughout the pediatric age range. Arterio-venous differences ranged from 28 to 78 ml of 0,/1 of blood. The mean was 44.3 ml/l with a S.D. of 15.0.Left ventricular cavity diameters are shown for 11 normal children from our series and 9 patients from the literature (fig.4). The two measurements recorded in the youngest subjects are elevated, probably as a result of our inability to distinguish that area of left ventricular 'wall' occupied by the thymus. The ratio of the left ventricular cavity diameter to wall thickness was 7.0 ( fig. 5).Calculated systemic, total pulmonary and pulmonary arteriolar resistances appeared to be inversely related to age, height, and weight. Therefore, it seemed that non-linear regression formulae employing the inverse of age, height and weight would be more suitable (table 111). Height alone gave the best correlation with all cardiac functions except output.Calculated resistances for both systemic and pulmonary circulations fall with increasing age at approximately the same rate (figs. 6-8). As systemic blood flow increases to accommodate the needs of increasing body size, the denominator of the DC resistance term increases and 'resistance' decreases.Since in the absence ofshunts, pulmonary blood flow must parallel the increase in systemic blood flow, pulmonary 'resistance' decreases pari passu. SpeculationHigh speed digital computers now make the development of regression equations increasingly simple. These equations will be increasingly employed by clinical investigators in place of 'surface area'.I t is also obvious that calculated 'resistances' tell us far less about the vascular bed than was formerly believed. Input impedance calculation will be employed in the future, particularly as better methods for measuring instantaneous flow become available.

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Determination of Human Body Surface Area From Height and Weight

Cited by 130 publications

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I.V. busulfan in pediatrics: a novel dosing to improve safety/efficacy for hematopoietic progenitor cell transplantation recipients

I.V. busulfan in pediatrics: a novel dosing to improve safety/efficacy for hematopoietic progenitor cell transplantation recipients

Body surface area estimation in children using weight alone: application in paediatric oncology

Hemodynamic Findings in Normal Children

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