<i>De Novo</i> Produced Anti-Human Leukocyte Antigen Antibodies Relation to Alloimmunity in Patients with Chronic Renal Failure

Pirim, İbrahim; Soyöz, Mustafa; Ayna, Tülay Kılıçaslan; Koçyiğit, Aslı Özkızılcık; Gürbüz, Burcu; Tuğmen, Cem; Kurtulmus, Yusuf; Özyılmaz, Berk

doi:10.1089/gtmb.2014.0294

Cited by 6 publications

(4 citation statements)

References 14 publications

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“…27 In the present study, in accordance with Lopes and associates, 7 we confirmed that a transplant has a high immunizing effect for both HLA class I and II compared with pregnancy and transfusion. Likewise, when we compared the antibody strengths (MFI values), as also reported by several authors, 6,28,29 we confirmed that a transplant, mainly for HLA class II, has a significantly higher antibody strength than pregnancy or transfusion. The presence of anti-HLA antibodies in our patients without any known sensitization event (11.4%) and the clinical significance of such antibodies are not clear.…”

Section: Discussionsupporting

confidence: 87%

Untitled

Resse¹,

Paolillo²,

Minucci³

et al. 2018

Exp Clin Transplant

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Objectives: Human leukocyte antigen alloimmunization is caused by exposure to HLA antigens through transfusion, pregnancy, or transplant. Our study objective was to present the rate of positivity of anti-HLA antibody considering the effects of a single sensitization event in kidney transplant candidates at our center. Materials and Methods: Our study reviewed 606 kidney transplant candidates. Patient sera were analyzed using Luminex xMAP technology. Panel reactive antibody positivity rates and antibody strengths in patients were analyzed according to a single sensitization event. Results: Our findings showed 246 patients (40.6%) with a panel reactive antibody > 0, of which 97 (39.4%) were sensitized from a single event, 119 (48.4%) were sensitized by multiple events, and 30 (12.2%) had no known sensitizing event. Considering patients sensitized by a single event with a panel reactive antibody > 0, we found that 25.8% had received transplant only, 49.5% had previous pregnancy only, and 24.7% had received transfusion only. The strength of antibodies was significantly higher in patients with previous transplant procedures than in those with transfusion for HLA-A (P < .01), HLA-B (P < .05), HLA-C (P < .05), HLA-DR (P < .001), HLA-DQ (P < .05), and HLA-DP (P < .05). Similarly, we observed significantly higher median fluorescence intensity values for HLA-A, -DR, -DQ, and -DP loci in patients with a previous transplant procedure versus preg nancy. The strength of antibodies against HLA-DR was significantly higher in patients with a previous pregnancy compared with those with transfusion (P < .01). Conclusions: This study documents the profile of HLA alloimmunization in kidney transplant candidates. In particular, transplant procedures appear to have a greater immunologic impact, followed by pregnancy and transfusion. Our data confirm and are in accordance with those of several studies in which the sensitization events were associated with higher prevalence of anti-HLA antibodies.

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Section: Discussionsupporting

confidence: 87%

Untitled

Resse¹,

Paolillo²,

Minucci³

et al. 2018

Exp Clin Transplant

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“…Lashley et al [3] found that this rise is probably due to the increase in fetal-maternal cell traffic in the last trimester. In our previous study, we found that the women on the transplant waiting list with only a pregnancy history produced more class II than class I anti-HLA antibodies [7]. Masson et al [2] also had the same results (86% and 62% of class I and class II anti-HLA antibodies, respectively).…”

Section: Discussionmentioning

confidence: 57%

Comparison of Anti-HLA Antibody Production According to Gestational Periods in Pregnant Women

Gürbüz

Soyöz

Okyay

et al. 2017

Transplantation Proceedings

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“…Risk factors for HLA sensitization include prior transplantation, blood product transfusion, pregnancy, and ventricular assist device use . Of these risk factors, the strongest is a history of prior transplantation.…”

Section: Hla System An Immunologic Barrier To Transplantationmentioning

confidence: 99%

Human Leukocyte Antigen Sensitization in Solid Organ Transplantation: A Primer on Terminology, Testing, and Clinical Significance for the Apheresis Practitioner

et al. 2017

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The human leukocyte antigen (HLA) system is an important immunologic barrier that must be considered for successful solid organ transplantation. Formation of donor-specific HLA antibodies in solid organ transplantation is an important cause of allograft injury and may contribute to recipient morbidity and mortality. Therapeutic plasma exchange is often requested to lower HLA antibody levels prior to or after transplantation and for management of HLA antibodies in the context of organ rejection. In this review, we summarize the current terminology, laboratory testing, and clinical significance of HLA sensitization in the solid organ transplant population. Furthermore, to illustrate applications of HLA testing in clinical practice, we summarize our own lung and kidney institutional protocols for managing HLA antibodies in the peri-transplant setting.

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De Novo Produced Anti-Human Leukocyte Antigen Antibodies Relation to Alloimmunity in Patients with Chronic Renal Failure

Cited by 6 publications

References 14 publications

Untitled

Untitled

Comparison of Anti-HLA Antibody Production According to Gestational Periods in Pregnant Women

Human Leukocyte Antigen Sensitization in Solid Organ Transplantation: A Primer on Terminology, Testing, and Clinical Significance for the Apheresis Practitioner

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