Comparison of Anti-HLA Antibody Production According to Gestational Periods in Pregnant Women

Gürbüz, Burcu; Soyöz, Mustafa; Okyay, D. Ozkale; Ayna, Tülay Kılıçaslan; Pirim, İbrahim

doi:10.1016/j.transproceed.2017.01.011

Cited by 7 publications

(1 citation statement)

References 10 publications

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“…When heteroantigen is first recognized by immune system, the antigen-specific antibody will be produced rapidly against the same antigen, as it is recognized again. Therefore, TRs are more common in patients with multiple transfusions [4] and in multiparous women [5]. The TR can develop even after removal of these possible factors by crossmatching and using pre-storage leukocyte-reduced components before infusing.…”

Section: Introductionmentioning

confidence: 99%

The Influence of CD28 Gene Polymorphism in Transfusion Reaction after Transfusing Leukoreduced Blood Components

Chen

Lin

Wang

et al. 2020

JCM

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CTLA-4 and CD28 belong to co-stimulation molecules, the abnormal expression of which can regulate the T cell activation and then affect the degree of immune response. Moreover, blood transfusion reaction (TR) is a kind of immune reaction. Consequently, the hypothesis of this study was that the TR still occurred after transfusing leukoreduced blood components as a result of the sensitivity of immune system, and a small number of immune stimulations were enough to induce an immune response in patients. There were 38 cases and 36 healthy controls included in this study. The selected CD28 gene were sequenced to search single nucleotide polymorphism (SNPs), and the correlation between TR and these SNPs was analyzed. According to our data, only the rs3181097 (promoter, −1059) of CD28 gene polymorphism was associated with TR. The p value of rs3181097 under the co-dominant model was 0.031. GG was used as a reference genotype, the p value of GG vs. AG was 0.010 (OR: 0.210, 95% CI: 0.062–0.712), and GG vs. AG + AA was 0.028 (OR: 0.292, 95% CI: 0.095–0.901). In addition to CTLA-4, CD28 gene was also a crucial SNP in TR, because there was a signification for the haplotype with Grs3181097 (p = 0.015). Consequently, we suggested that the TR was related to CD28 by regulating the degree of immune response.

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Section: Introductionmentioning

confidence: 99%

The Influence of CD28 Gene Polymorphism in Transfusion Reaction after Transfusing Leukoreduced Blood Components

Chen

Lin

Wang

et al. 2020

JCM

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Immunological harmony: the dynamic influence of cellular and humoral immunity on pregnancy success

Pandey

2024

Discov. Immun.

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This study is a crucial step in understanding the dynamics of the maternal immune response directed at paternal human leukocyte antigen (HLA) molecules. HLA molecules are proteins on cell surfaces that play a critical role in immune system regulation. Our findings focus on the pivotal role of maternal antibodies targeting fetal HLA molecules in inhibiting antigen-induced activation of uterine immune cells, which is essential for successful pregnancies. Antibodies are proteins produced by the immune system that recognize and neutralize foreign substances. The primary focus is to unravel maternal anti-fetal rejection by drawing parallels to transplant rejection and emphasizing the role of allorecognition—the process by which an individual’s immune system recognizes and responds to antigens from another individual of the same species—in both cellular (involving immune cells) and humoral (involving antibodies) refusal. Although exploring anti-HLA antibodies in preventing fetal loss in patients with recurrent spontaneous abortion is captivating, there are still significant knowledge gaps that need to be addressed. Further studies are imperative to reveal the precise mechanism by which these antibodies generate and prevent maternal immune responses, critical determinants of pregnancy outcomes. It is vital to investigate the specificity of these antibodies and whether they exclusively target specific HLA molecules on trophoblasts (cells forming the outer layer of a blastocyst, providing nutrients to the embryo). This review paper not only offers insights into the development of these protective antibodies in pregnancy but also lays the foundation for future research on therapeutic implications, particularly in cases of recurrent spontaneous abortion.

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Reproductive health after thoracic transplantation: An ISHLT expert consensus statement

Kittleson

DeFilippis

Bhagra

et al. 2023

The Journal of Heart and Lung Transplantation

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Comparison of Anti-HLA Antibody Production According to Gestational Periods in Pregnant Women

Cited by 7 publications

References 10 publications

The Influence of CD28 Gene Polymorphism in Transfusion Reaction after Transfusing Leukoreduced Blood Components

The Influence of CD28 Gene Polymorphism in Transfusion Reaction after Transfusing Leukoreduced Blood Components

Immunological harmony: the dynamic influence of cellular and humoral immunity on pregnancy success

Reproductive health after thoracic transplantation: An ISHLT expert consensus statement

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