<i>CYP19A1</i> gene polymorphisms and risk of lung cancer

Zhang, Jie; Yin, Yue; Xiao, Ning; Liu, Yun; Garfield, David H.; Chen, Su Feng; Wang, Rui; Wang, Lei; Chen, Hai Quan

doi:10.1177/0300060513477291

Cited by 14 publications

(13 citation statements)

References 17 publications

(16 reference statements)

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“…Zhang et al have shown that CYP19A1-rs727479 was signi cantly associated with the incidence of lung cancer. In particular, haplotype rs727479|rs730154|rs10046-ACA was only signi cantly associated with nonsmokers and female nonsmokers 17 .…”

Section: Discussionmentioning

confidence: 90%

“…SNPs in CYP19A1 were found to be associated with cancer risk in European Americans, North Indians, and Chinese 24,25 . In particular, CYP19A1 SNPs have been shown to be signi cantly associated with lung-related diseases 16,17 .…”

Section: Discussionmentioning

confidence: 99%

“…This suggests that CYP19A1 genetic variation may indirectly affect the occurrence of lung cancer, but the exact mechanism is unclear. At the same time, many literatures have reported the inseparable relationship between CYP19A1 gene and lung-related diseases, including lung cancer [15][16][17] .…”

Section: Introductionmentioning

confidence: 99%

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The rs28757157 and rs59429575 polymorphisms in CYP19A1 are associated with lung cancer in Chinese Han population

Zhang

Cheng

Chen

et al. 2020

Preprint

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Background: Lung cancer is the leading cause of cancer death globally. Recent studies have revealed that the CYP19A1 gene played a crucial role in cancer initiation and development. The aim of this study was to assess the association of CYP19A1 genetic polymorphisms with the risk of lung cancer in the Chinese Han population. Method: This study randomly recruited 507 lung cancer patients and 505 healthy controls. The genotypes of four SNPs of CYP19A1 gene were identified by Agena MassARRY technique. Genetic model analysis was used to assess the association between genetic variation and lung cancer risk. Odds ratio (OR) values and 95% confidence intervals (CIs) were provided for the evaluation of the lung cancer risk effect. Results: Rs28757157 and rs59429575 polymorphisms of CYP19A1 were significantly correlated with the risk of lung cancer. In stratified analysis, rs28757157 was associated with increased cancer risk in smokers and individuals aged ≤ 60 years. Meanwhile, rs59429575 was identified as a risk biomarker in females and lung adenocarcinoma patients (p < 0.05). While rs28757157 exerted a protective role among people with a BMI greater than 24 (p = 0.033). Conclusions: This study identified two new SNPs (rs28757157 and rs59429575) of CYP19A1 associated with lung cancer in Chinese Han population. These findings provide data support for further functional studies of CYP19A1 in lung cancer.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The rs28757157 and rs59429575 polymorphisms in CYP19A1 are associated with lung cancer in Chinese Han population

Zhang

Cheng

Chen

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…This suggests that CYP19A1 genetic variation may indirectly affect the progression of lung cancer, but the exact mechanism is unclear. At the same time, many literatures have reported the inseparable relationship between CYP19A1 gene and lung-related diseases, including lung cancer (15)(16)(17).…”

Section: Introductionmentioning

confidence: 99%

The rs28757157 and rs59429575 polymorphisms in CYP19A1 are associated with lung cancer in Chinese Han population

Zhang

Cheng

Chen

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Lung cancer is the leading cause of cancer death globally. Recent studies have revealed that the CYP19A1 gene played a crucial role in cancer initiation and development. Objectives: The aim of this study was to assess the association of CYP19A1 genetic polymorphisms with the risk of lung cancer in Chinese Han population. Method: This study randomly recruited 507 lung cancer patients and 505 healthy controls. The genotypes of four SNPs of CYP19A1 gene were identified by Agena MassARRY technique. Genetic model analysis was used to assess the association between genetic variation and lung cancer risk. Odds ratio (OR) values and 95% confidence intervals (CIs) were provided for the evaluation of the lung cancer risk effect. Results: Rs28757157 and rs59429575 polymorphisms of CYP19A1 were significantly correlated with the risk of lung cancer. In stratified analysis, rs28757157 was associated with increased cancer risk in males and smoker. Meanwhile, rs59429575 was identified as a risk biomarker in female and lung adenocarcinoma patients (p < 0.05). While rs28757157 exerted protective role among people with a BMI greater than 24 (p = 0.033). Conclusions: This study identified two new SNPs (rs28757157 and rs59429575) of CYP19A1 associated with lung cancer in Chinese Han population. These findings provide data support for further functional studies of CYP19A1 in lung cancer.

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“…Current data show that all cancer types are in some way related with the level of estrogen, estrogen receptors and aromatase or their polymorphisms [11][12][13][14]. Generally estrogen receptor (ER) alpha promotes proliferation, while ER beta supresses it but this is not the rule for all tissues; moreover, the ER status varies between neoplastic tissues.…”

Section: Introductionmentioning

confidence: 99%

Gender and Age Related Modulation of Xenoestrogen-Induced Tumorigenesis

Fučić¹,

Mantovani²

2015

TOBIOTJ

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Susceptibility to environmental stressors, same as cancer incidence is both age and gender related. Understanding the complexity of responses to living environment has been impaireddue to research based on reductionisms and lack of methods, models and sophisticated softwares which enable analysis of complex pathways which may be disturbed by xenobotics. Impact of estrogen on development, maturation and homeostasis of organism in both genders is now well recognised and environmental investigations are currently making major efforts to understand how xenoestrogens affect organisms at very low doses.Additionally, it is of great interest to learn possible synergistic or antagonistic effects of xenoestrogen mixtures on adult organism and during development. The aim of this paper is to review the findings on the association between cancer risk and the endocrine disrupters which directly or indirectly mimic estrogen action.

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CYP19A1 gene polymorphisms and risk of lung cancer

Abstract: Polymorphisms of CYP19A1 may be related to the increased risk of lung cancer; in particular, haplotype ACA may contribute to lung-cancer progression in nonsmokers. Further validation with larger populations is required.

Cited by 14 publications

References 17 publications

The rs28757157 and rs59429575 polymorphisms in CYP19A1 are associated with lung cancer in Chinese Han population

The rs28757157 and rs59429575 polymorphisms in CYP19A1 are associated with lung cancer in Chinese Han population

The rs28757157 and rs59429575 polymorphisms in CYP19A1 are associated with lung cancer in Chinese Han population

Gender and Age Related Modulation of Xenoestrogen-Induced Tumorigenesis

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