<i>CYBA</i> C242T polymorphism is associated with obesity and diabetes mellitus in Brazilian hypertensive patients

Schreiber, Roberto; Ferreira-Sae, Maria C.; Tucunduva, A. C.; Mill, José Geraldo; Costa, Felipe Osório; Franchini, Kleber G.; Pereira, Ana Cláudia; Nadruz, Wilson

doi:10.1111/j.1464-5491.2012.03594.x

Cited by 10 publications

(10 citation statements)

References 31 publications

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“…Similarly, a statistically significant association between the C242T polymorphism and hypertension has been reported by Ji et al [33]. Subsequent studies [34-40] have been conducted to investigate the association between the C242T polymorphism and hypertension. However, the results have generated considerable controversy.…”

Section: Introductionmentioning

confidence: 58%

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The A930G Polymorphism of P22phox (CYBA) Gene but Not C242T Variation Is Associated with Hypertension: A Meta-Analysis

et al. 2013

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BackgroundRecently, it has been reported that the A930G and C242T polymorphisms within p22phox (CYBA) gene are involved in the pathogenesis of hypertension. However, the results remain controversial. Furthermore, no previous meta-analysis has been conducted to evaluate the relationship between the A930G and C242T polymorphisms and hypertension. Therefore, we performed this meta-analysis to clarify these controversies.Objective and MethodsAll of the included articles were retrieved from the PubMed and Embase databases, as well as the CNKI, CBM, Chongqing VIP and Wan Fang databases according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Odds ratios (OR) with corresponding 95% confidence intervals (CI) were used to assess the strength of the association. Accounting for heterogeneity, a fixed or random effects model was respectively adopted. Heterogeneity was checked using the Q test and the I2 statistic. A cumulative meta-analysis was conducted to estimate the tendency of pooled OR. Funnel plots and Egger’s tests were performed to test for possible publication bias.ResultsFive articles on A930G with 2003 cases/2434 controls and eight articles on C242T with 2644 cases/1967 controls were identiﬁed. A signiﬁcant association of A930G polymorphisms with the risk of hypertension was found in the dominant model (OR=0.59, 95% CI: 0.38–0.92, p=0.021) and allelic model (OR=0.66, 95% CI: 0.46–0.95, p=0.024). In the stratified analysis, a signiﬁcant association could be found among the hospital-based and population-based studies. However, no evidence of a significant association of the C242T polymorphism with hypertension was found in the overall analysis and subgroup analysis.ConclusionsThis meta-analysis indicates that the A930G polymorphism, but not the C242T variation, might be a protective factor for hypertension.

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Section: Introductionmentioning

confidence: 58%

“…Studies were conducted from 2003 to 2013 among various ethnicities (four studies involved in Caucasians and four involved Asians). Three studies were population-based [34,35,37] and five were hospital-based studies [33,36,38-40]. Genotyping was consistently performed in these studies by PCR.…”

Section: Resultsmentioning

confidence: 99%

The A930G Polymorphism of P22phox (CYBA) Gene but Not C242T Variation Is Associated with Hypertension: A Meta-Analysis

et al. 2013

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“…The clinical, anthropometric and laboratory characteristics of studied subjects according to C242T genotypes are shown in Table 1. Given the described dominant effect of the T allele in functional and association studies [7], [10], [11], [23]–[25] TT subjects were added to CT subjects. No differences in the clinical and laboratory characteristics were detected between the genotype subgroups.…”

Section: Resultsmentioning

confidence: 99%

“…The p22-phox C242T polymorphism was analyzed by polymerase chain reaction and digestion with Rsa-I restriction enzyme as those reported previously [10]. Quality control for these assays was assessed by randomly selecting 100 samples to be re-genotyped by two independent technicians.…”

Section: Methodsmentioning

confidence: 99%

“…Although a significant heterogeneity for a modulating role of the p22-phox C242T polymorphism in the occurrence of cardiovascular disease has been reported, recent meta-analyses have suggested that the T allele is associated with increased cardiovascular risk, albeit significant associations were detected in some but not in all studied ethnic groups [8], [9]. Likewise, studies performed in urban Brazilian populations have shown that the T allele is associated with unfavorable cardiovascular phenotypes and increased NADPH oxidase activity [10], [11].…”

Section: Introductionmentioning

confidence: 99%

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Influence of the C242T Polymorphism of the p22-phox Gene (CYBA) on the Interaction between Urinary Sodium Excretion and Blood Pressure in an Urban Brazilian Population

et al. 2013

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BackgroundReactive oxygen species are implicated in the physiopathogenesis of salt-induced hypertension and the C242T polymorphism of the p22-phox gene has been associated with higher superoxide production. This study investigated the impact of this polymorphism on the relationship between urinary sodium excretion (USE) and blood pressure levels in an urban Brazilian population.MethodsWe cross-sectionally evaluated 1,298 subjects from the city of Vitoria-ES, located in the Southeast region of Brazil, by clinical history, physical examination, anthropometry, analysis of laboratory parameters, USE measurement and p22-phox C242T polymorphism genotyping.ResultsNo significant differences in studied parameters were detected between the studied genotype groups (CC vs. CT+TT). Systolic blood pressure exhibited significant correlation with USE only in T allele carriers (r = 0.166; p<0.001), while diastolic blood pressure and hypertension status correlated with USE in both genotypes albeit more weakly in subjects with CC genotype (r = 0.098; p = 0.021 and r = 0.105; p = 0.013, respectively) than in T carriers (r = 0.236; p<0.001 and r = 0.213; p<0.001, respectively). Regression analyses adjusted for confounding factors showed that USE remained independently associated with systolic (p<0.001) and diastolic blood pressure (p<0.001) and hypertension status (p = 0.004) only in T allele carriers. Finally, higher diastolic and systolic blood pressure levels were detected in T allele carriers than in CC genotype individuals in the highest tertile of USE.ConclusionsThe p22-phox 242T allele is associated with higher blood pressure levels among subjects with higher USE in an urban Brazilian population.

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Genetics of Oxidative Stress and Obesity-Related Diseases

Rupérez

Anguita‐Ruiz

2018

Obesity

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CYBA C242T polymorphism is associated with obesity and diabetes mellitus in Brazilian hypertensive patients

Abstract: These data suggest that the T allele of the CYBA C242T polymorphism may be used as a marker for adverse metabolic features in Brazilian subjects with systemic hypertension.

Cited by 10 publications

References 31 publications

The A930G Polymorphism of P22phox (CYBA) Gene but Not C242T Variation Is Associated with Hypertension: A Meta-Analysis

The A930G Polymorphism of P22phox (CYBA) Gene but Not C242T Variation Is Associated with Hypertension: A Meta-Analysis

Influence of the C242T Polymorphism of the p22-phox Gene (CYBA) on the Interaction between Urinary Sodium Excretion and Blood Pressure in an Urban Brazilian Population

Genetics of Oxidative Stress and Obesity-Related Diseases

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