Influence of the C242T Polymorphism of the p22-phox Gene (CYBA) on the Interaction between Urinary Sodium Excretion and Blood Pressure in an Urban Brazilian Population

Abstract

BackgroundReactive oxygen species are implicated in the physiopathogenesis of salt-induced hypertension and the C242T polymorphism of the p22-phox gene has been associated with higher superoxide production. This study investigated the impact of this polymorphism on the relationship between urinary sodium excretion (USE) and blood pressure levels in an urban Brazilian population.MethodsWe cross-sectionally evaluated 1,298 subjects from the city of Vitoria-ES, located in the Southeast region of Brazil, by clinical history, physical examination, anthropometry, analysis of laboratory parameters, USE measurement and p22-phox C242T polymorphism genotyping.ResultsNo significant differences in studied parameters were detected between the studied genotype groups (CC vs. CT+TT). Systolic blood pressure exhibited significant correlation with USE only in T allele carriers (r = 0.166; p<0.001), while diastolic blood pressure and hypertension status correlated with USE in both genotypes albeit more weakly in subjects with CC genotype (r = 0.098; p = 0.021 and r = 0.105; p = 0.013, respectively) than in T carriers (r = 0.236; p<0.001 and r = 0.213; p<0.001, respectively). Regression analyses adjusted for confounding factors showed that USE remained independently associated with systolic (p<0.001) and diastolic blood pressure (p<0.001) and hypertension status (p = 0.004) only in T allele carriers. Finally, higher diastolic and systolic blood pressure levels were detected in T allele carriers than in CC genotype individuals in the highest tertile of USE.ConclusionsThe p22-phox 242T allele is associated with higher blood pressure levels among subjects with higher USE in an urban Brazilian population.

Interactions between genetic and lifestyle factors on cardiometabolic disease-related outcomes in Latin American and Caribbean populations: A systematic review

“…In line with these findings, a case-control study of 234 elderly people ( 82 ) reported an interaction between sodium intake and angiotensin-converting enzyme ( ACE ) SNP rs4646994 on the risk of hypertension, where carriers of the “ I/I ” genotype with a high sodium intake (>2 g/day) had an increased risk of hypertension ( P interaction = 0.007). Furthermore, in a cross-sectional study of 1298 healthy adults ( 83 ), those carrying the “ T ” allele of Cytochrome B-245 Alpha Chain ( CYBA ) ( p22phox ) with more than 86.5 mEq sodium per 12 h of urine collection, had increased SBP ( P interaction < 0.001) and DBP ( P interaction = 0.011). Sodium is known to increase BP by reducing vasodilation ( 86 ), while dietary calcium is believed to stabilize intracellular calcium in smooth muscles, thereby reducing vasoconstriction and BP ( 87 ).…”

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Association study of C936T polymorphism of the VEGF gene and the C242T polymorphism of the p22phox gene with diabetes mellitus type 2 and distal diabetic polyneuropathy

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Evaluating the use of Instagram images color histograms and hashtags sets for automatic image annotation

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