<i>CTLA-4</i> Polymorphisms and Systemic Lupus Erythematosus: A Comprehensive Meta-Analysis

Liu, Jie

doi:10.1089/gtmb.2012.0302

Cited by 15 publications

(8 citation statements)

References 38 publications

(46 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This SNP was shown to play an important role in T and B cell receptor signaling (5). The SNP rs3087243 in CTLA4 is associated with several autoimmune diseases, including SLE, RA, T1D, and Graves' disease (8,(10)(11)(12)(13)(14). The CTLA4 SNP has a protective effect, and the major allele G is associated with autoimmunity.…”

Section: Introductionmentioning

confidence: 99%

Autoimmunity-Related Risk Variants in PTPN22 and CTLA4 Are Associated With ME/CFS With Infectious Onset

et al. 2020

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Autoimmunity-Related Risk Variants in PTPN22 and CTLA4 Are Associated With ME/CFS With Infectious Onset

et al. 2020

View full text Add to dashboard Cite

“…However, its precise mechanism of action has not been fully resolved. Recently abnormal CTLA-4 gene polymorphisms and function has been reported in SLE patients (52,53). For the first time to our knowledge, in this system we found that B cells and granulocytes also can be "tolerized" and subsequently function as regulatory/suppressor cells to prevent production of autoantibodies.…”

Section: Discussionmentioning

confidence: 55%

“…However, its precise mechanism of action has not been fully resolved. Recently abnormal CTLA-4 gene polymorphisms and function has been reported in SLE patients ( 52 , 53 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of Peptide-Induced Immune Tolerance on Murine Lupus

2021

View full text Add to dashboard Cite

The regulation of autoimmunity and the molecular mechanisms by which different immune cells, including T cells, polymorphonuclear leukocytes (PMN-granulocytes), and B cells suppress autoimmune diseases is complex. We have shown previously that BWF1 lupus mice are protected from autoimmunity after i.v. injection or oral administration of tolerogenic doses of pCons, an artificial synthetic peptide based on sequences containing MHC class I and MHC class II determinants in the VH region of a J558-encoded BWF1 anti-DNA Ab. Several T cell subsets can transfer this tolerance. In this study, we determined the potential roles of granulocytes, B cells and regulatory T cells altered by pCons treatment in the BWF1 (NZB/NZW) mouse model of lupus. Immunophenotyping studies indicated that pCons treatment of BWF1 mice significantly increased CD4+FoxP3+ T cells, reduced the percent of B cells expressing CD19+CD5+ but increased the percent of CD19+CD1d+ regulatory B cells and increased the ability of the whole B cell population to suppress IgG anti-DNA production in vitro. pCons treatment significantly decreased the expression of CTLA-4 (cytotoxic T-lymphocyte-associated protein-4) in CD8+ T cells. In addition, peptide administration modified granulocytes so they became suppressive. We co-cultured sorted naïve B cells from mice making anti-DNA Ab (supported by addition of sorted naive CD4+ and CD8+ T cells from young auto-antibody-negative BWF1 mice) with sorted B cells or granulocytes from tolerized mice. Both tolerized granulocytes and tolerized B cells significantly suppressed the production of anti-DNA in vitro. In granulocytes from tolerized mice compared to saline-treated littermate controls, real-time PCR analysis indicated that expression of interferon-induced TNFAIP2 increased more than 2-fold while Ptdss2 and GATA1 mRNA were up-regulated more than 10-fold. In contrast, expression of these genes was significantly down-regulated in tolerized B cells. Further, another IFN-induced protein, Bcl2, was reduced in tolerized B cells as determined by Western blot analyses. In contrast, expression of FoxP3 was significantly increased in tolerized B cells. Together, these data suggest that B cells and granulocytes are altered toward suppressive functions by in vivo tolerization of BWF1 mice with pCons and it is possible these cell types participate in the clinical benefits seen in vivo.

show abstract

“…Specifically, they may alter the transcription capacity of the CD152 gene [ 18 ], the processing and transport of CD152 protein [ 19 ], and the interactions between CD152 and CD80 ligand [ 20 ]. Therefore, they have been widely explored their influences on autoimmune disorders [ 21 ] and cancer [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Role of CD152 genetic polymorphisms in the susceptibility to breast cancer

Hai

Bai

et al. 2017

Oncotarget

View full text Add to dashboard Cite

BackgroundThe polymorphisms in cluster of differentiation 152 (CD152) gene have been reported to be associated with breast cancer (BC), but relevant findings were far from conclusive. Therefore, we carried out this meta-analysis to combine those results for a clearer perspective on this issue.ResultsIn our meta-analysis, a total of 8 eligible publications of 19 case-control studies were selected, which totally contained 7,442 BC cases and 7,376 normal controls. Among the five polymorphisms of CD152 gene, +49 G/A, −1661 A/G and −318 C/T significantly increased the risk of BC under corresponding genetic comparisons; while CT60 G/A polymorphism was negatively related to the cancer susceptibility. In addition, −1772 T/C polymorphism of CD152 gene was not associated with the development of BC.Materials and methodsOnline databases and other sources were searched for published studies on the relationship between BC susceptibility and CD152 polymorphisms (+49 G/A, −1661 A/G, −1722 T/C, −318 C/T and CT60 G/A). The strength of association was evaluated with pooled odds ratios (ORs) and their corresponding 95% confidence intervals (95% CIs). Heterogeneity evaluation was conducted via Q test. Sensitivity analysis was used to detect the stability of our results. Begg's funnel plot and Egger's test were applied to investigate publication bias among selected studies.ConclusionsThe polymorphisms +49 G/A, −1661 A/G and −318 C/T may elevate the susceptibility to BC, but the polymorphism CT60 G/A may offer protection against the cancer.

show abstract

CTLA-4 Polymorphisms and Systemic Lupus Erythematosus: A Comprehensive Meta-Analysis

Cited by 15 publications

References 38 publications

Autoimmunity-Related Risk Variants in PTPN22 and CTLA4 Are Associated With ME/CFS With Infectious Onset

Autoimmunity-Related Risk Variants in PTPN22 and CTLA4 Are Associated With ME/CFS With Infectious Onset

Effects of Peptide-Induced Immune Tolerance on Murine Lupus

Role of CD152 genetic polymorphisms in the susceptibility to breast cancer

Contact Info

Product

Resources

About