<i>Coxiella burnetii</i>(Q Fever) Infection in Farmed Ruminants in Three Northeastern Provinces and Inner Mongolia Autonomous Region, China

Cong, Wei; Meng, Qing-Feng; Shan, Xiaofeng; Sun, Wu-Wen; Kang, Yuan-Huan; Chen, Long; Wang, Weili; Ai-dong, Qian

doi:10.1089/vbz.2015.1789

Cited by 14 publications

(4 citation statements)

References 19 publications

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“…Previous studies about C. burnetii infection in China focused on human and domestic animals, with significant variation in the detection of C. burnetii. For example, C. burnetii was found in 20.5% of cattle sampled in Xinjiang (Li et al 2020), 24.9% in sheep and 12.3% of Sika deer (Cong et al 2015), and 4.7% of goats in Hubei province, China , indicating that C. burnetii infection varies for different animals and regions. Importantly, our results indicated that wild ruminants have relatively high infection with C. burnetii, suggesting that these animals are important carriers for C. burnetii.…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of Five Zoonotic Pathogens in Wild Ruminants in Xinjiang, Northwest China

Wang

et al. 2020

Vector-Borne and Zoonotic Diseases

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Wild ruminants are at risk for zoonotic pathogen infection as a result of interactions with domestic animals and humans. One way to assess the level of a wild ruminant disease in a population is to determine the seroprevalence of the pathogen of interest. The objective of this study was to determine the seroprevalence of five zoonotic pathogens in wild ruminants in Xinjiang, Northwest China. In 2009 and 2011-2015, 258 wild ruminant sera samples were collected from various species. Samples were obtained from 30 Siberian ibexes, 94 goitered gazelles, 6 Tibetan antelopes, 32 argali sheep, 16 roe deer, 20 blue sheep, 56 red deer, and 4 wild yaks, in 10 regions of Xinjiang. Samples were tested using antibodies against Brucella spp., Chlamydophila abortus, Coxiella burnetii, Toxoplasma gondii, and West Nile virus. Seropositivity was detected for all five pathogens, with detection rates of Brucella spp., C. abortus, C. burnetii, T. gondii, and West Nile virus of 2.3% (95% confidence interval [CI], 0.5-4.2%), 6.2% (95% CI, 3.3-9.1%), 7.8% (95% CI, 4.5-11.0%), 2.3% (95% CI, 0.5-4.2%), and 0.8% (95% CI, 0-1.8%), respectively. The level of pathogens differed for different species and different regions. The results indicate that seropositivity to zoonotic pathogens is common among wild ruminants in Xinjiang, Northwest China, with C. burnetii and C. abortus detected at the highest levels. This study provides a baseline for future assessment of spillover events.

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Section: Discussionmentioning

confidence: 99%

Seroprevalence of Five Zoonotic Pathogens in Wild Ruminants in Xinjiang, Northwest China

Wang

et al. 2020

Vector-Borne and Zoonotic Diseases

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“…In China, infection has been detected in humans as well as in a wide range of wild, domestic, and farmed animals such as cattle, goats, dogs, pigs, mice, sheep, and horses [ 14 ]. In the previous study, we reported the seroprevalence of C. burnetii infection in farmed ruminants including cattle in the three northeastern provinces and Inner Mongolia Autonomous Region, China [ 15 ]. However, information on the seroprevalence and risk factors for acquisition of C. burnetii infection in cattle farmers and farm residents is limited.…”

Section: Introductionmentioning

confidence: 99%

Coxiella burnetiiSeroprevalence and Risk Factors in Cattle Farmers and Farm Residents in Three Northeastern Provinces and Inner Mongolia Autonomous Region, China

Sun¹,

Cong²,

Li³

et al. 2016

BioMed Research International

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Little is known about Coxiella burnetii infection among cattle farmers and farm residents in China. Thus, the present study was conducted to detect the seroprevalence of C. burnetii infection and estimate associated risk factors among cattle farmers and farm residents in China. A cross-sectional study was designed, and sera of 362 people living or working on 106 cattle farms were tested for C. burnetii IgG and IgM antibodies by immunofluorescence assay. Overall C. burnetii seroprevalence was 35.6% (129/362, 95% CI: 30.70–40.57), and 112 participants had experienced a past infection and seventeen (4.7%) had experienced a relatively recent infection. In the final combined multilevel model, the following activities were significantly associated with presence of antibodies against C. burnetii: milking cattle, providing general healthcare to cattle, providing birth assistance, contact dead-born animals, urbanization, and presence of mice and/or rats in the stable. Moreover, presence of disinfection equipment was a significant protective factor. This is the first study addressing the seroprevalence and risk factors of C. burnetii infection in cattle farmers and farm residents in three northeastern provinces and Inner Mongolia Autonomous Region, China.

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“…A serological screening of over 3000 livestock found that the seroprevalence of Q fever was 24.9% in cattle and 13.5% in sheep. [18] Based on a seroepidemiological survey, the positive rate of Q fever serology ranges from 1.6% to 28.7% in healthy people living in the Southwestern Chinese Provinces of Guizhou, Sichuan, Yunnan, and Tibet. [1519] The high positive rate of Q fever serology and the low number of Q fever endocarditis cases suggest that Q fever endocarditis may be an underreported and under-identified disease in China.…”

Section: Discussionmentioning

confidence: 99%

Retrospective Examination of Q Fever Endocarditis

Han

Hsu

Miao

et al. 2017

Chinese Medical Journal

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Background:Q fever endocarditis, a chronic illness caused by Coxiella burnetii, can be fatal if misdiagnosed or left untreated. Despite a relatively high positive rate of Q fever serology in healthy individuals in the mainland of China, very few cases of Q fever endocarditis have been reported. This study summarized cases of Q fever endocarditis among blood culture negative endocarditis (BCNE) patients and discussed factors attributing to the low diagnostic rate.Methods:We identified confirmed cases of Q fever endocarditis among 637 consecutive patients with infective endocarditis (IE) in the Peking Union Medical College Hospital between 2006 and 2016. The clinical findings for each confirmed case were recorded. BCNE patients were also examined and each BCNE patient's Q fever risk factors were identified. The risk factors and presence of Q fever serologic testing between BCNE patients suspected and unsuspected of Q fever were compared using the Chi-squared or Chi-squared with Yates’ correction for continuity.Results:Among the IE patients examined, there were 147 BCNE patients, of whom only 11 patients (7.5%) were suspected of Q fever and undergone serological testing for C. burnetii. Six out of 11 suspected cases were diagnosed as Q fever endocarditis. For the remaining136 BCNE patients, none of them was suspected of Q fever nor underwent relevant testing. Risk factors for Q fever endocarditis were comparable between suspected and unsuspected patients, with the most common risk factors being valvulopathy in both groups. However, significantly more patients had consulted the Infectious Diseases Division and undergone comprehensive diagnostic tests in the suspected group than the unsuspected group (100% vs. 63%, P = 0.03).Conclusions:Q fever endocarditis is a serious yet treatable condition. Lacking awareness of the disease may prevent BCNE patients from being identified, despite having Q fever risk factors. Increasing awareness and guideline adherence are crucial in avoiding misdiagnosing and missed diagnosing of the disease.

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Coxiella burnetii(Q Fever) Infection in Farmed Ruminants in Three Northeastern Provinces and Inner Mongolia Autonomous Region, China

Cited by 14 publications

References 19 publications

Seroprevalence of Five Zoonotic Pathogens in Wild Ruminants in Xinjiang, Northwest China

Seroprevalence of Five Zoonotic Pathogens in Wild Ruminants in Xinjiang, Northwest China

Coxiella burnetiiSeroprevalence and Risk Factors in Cattle Farmers and Farm Residents in Three Northeastern Provinces and Inner Mongolia Autonomous Region, China

Retrospective Examination of Q Fever Endocarditis

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