<i>Corynebacterium striatum</i>Bacteremia Associated with a Catheter-Related Blood Stream Infection

Ueno, Daisuke; Oishi, Tomohiro; Yamane, Kunikazu; Terada, Kihei

doi:10.1155/2017/2682149

Cited by 17 publications

(17 citation statements)

References 15 publications

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“…Corynebacterium striatum has been increasingly associated with severe infections in both immunocompetent and immunocompromised hosts [3, 4]. However, C. striatum isolates have been included among the etiologic agents of bacteremia with or without central venous catheter (CVC) in place [5, 6], endocarditis [7], breast abscesses [8], septic arthritis [2], osteomyelitis [4] and several other invasive diseases. In addition, studies have evidenced C. striatum as an emerging multidrug-resistant (MDR) pathogen related to nosocomial outbreaks in several countries [9–16].…”

Section: Introductionmentioning

confidence: 99%

Bloodstream and catheter-related infections due to different clones of multidrug-resistant and biofilm producer Corynebacterium striatum

et al. 2019

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Background Corynebacterium striatum is an emerging multidrug-resistant (MDR) pathogen associated with immunocompromised and chronically ill patients, as well as nosocomial outbreaks. In this study, we characterized 23 MDR C. striatum isolated of bloodstream and catheter-related infections from a hospital of Rio de Janeiro. Methods C. striatum isolates were identified by 16S rRNA and rpoB genes sequencing. The dissemination of these isolates was accomplished by pulsed-field gel electrophoresis (PFGE). All isolates were submitted to antimicrobial susceptibility testing by disk diffusion and by minimum inhibitory concentration using E-test strips methods. Antimicrobial resistance genes were detected by polymerase chain reaction. Quantitative tests were performed on four different abiotic surfaces and the ability to produce biofilm on the surface of polyurethane and silicone catheter was also demonstrated by scanning electron microscopy. Results Eleven PFGE profiles were found. The PFGE profile I was the most frequently observed among isolates. Five different MDR profiles were found and all PFGE profile I isolates presented susceptibility only to tetracycline, vancomycin, linezolid and daptomycin. Only the multidrug-susceptible isolate did not show mutations in the quinolone-resistance determinant region (QRDR) of the gyrA gene and was negative in the search of genes encoding antibiotic resistance. The other 22 isolates were positive to resistance genes to aminoglycoside, macrolides/lincosamides and chloramphenicol and showed mutations in the QRDR of the gyrA gene. Scanning electron microscopy illustrated the ability of MDR blood isolate partaker of the epidemic clone (PFGE profile I) to produce mature biofilm on the surface of polyurethane and silicone catheter. Conclusions Genotyping analysis by PFGE revealed the permanence of the MDR PFGE profile I in the nosocomial environment. Other new PFGE profiles emerged as etiologic agents of invasive infections. However, the MDR PFGE profile I was also found predominant among patients with hematogenic infections. The high level of multidrug resistance associated with biofilm formation capacity observed in MDR C. striatum is a case of concern. Electronic supplementary material The online version of this article (10.1186/s12879-019-4294-7) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Bloodstream and catheter-related infections due to different clones of multidrug-resistant and biofilm producer Corynebacterium striatum

et al. 2019

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“…Recent studies have increasingly reported that the following strains are important causes of infection: C. striatum, C. jeikeum, C. amycolatum, C. urealyticum, C. afermentans, C. ulcerans, C. minitissimum, C. propinquum, and C. pseudodiphtheriticum 3 . Studies investigating various clinical specimens have indicated that between 44% and 71% of patients with Corynebacterium bacteremia have true infections [13][14][15] .…”

Section: Discussionmentioning

confidence: 99%

“…are normal flora bacteria in human skin and mucous membranes. When isolated from clinical specimens they cause serious infections and nosocomial outbreaks in critically ill immunocompromised patients, for example in those with end-stage cancer, hematologic malignancy, or who have prosthetic devices or stayed for prolonged periods in a hospital or nursing homes [3][4][5] . Nosocomial outbreaks, especially due to Corynebacterium striatum, are increasing in both industrialized and developing countries.…”

Section: Introductionmentioning

confidence: 99%

Biofilm Formation and Antimicrobial Susceptibility of Non-Diphtheriae Corynebacterium Strains Isolated from Blood Cultures: First Report from Turkey

Özdemir¹,

Aydoğan²,

Çakırlar³

2021

MMJ

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Objective: Non-diphtheriae Corynebacterium strains have been recognized as important pathogens after decades of confusion regarding their microbiological classification and clinical significance. The aim of this study was to identify non-diphtheriae Corynebacterium strains and the prevalence of biofilm formation and antimicrobial resistance. Method: In total, 126 non-diphtheriae Corynebacterium strains were isolated from blood cultures of inpatients with bacteremia in our hospital between January 2015 and January 2020. Blood cultures were analyzed with the Bactec-9120 system. Strains were identified using MALDI-TOF MS (Bruker Daltonics, Germany). Antimicrobial susceptibilities were determined using the Kirby-Bauer disk diffusion method on a Mueller-Hinton agar and evaluated according to EUCAST standards. Biofilm formation was assessed with the Congo Red Agar method. Results: Corynebacterium striatum and Corynebacterium matruchotii were the most prevalent with 29 and 26 isolates, respectively. Biofilm production was detected in 62.06% (18/29) of C. striatum, in 53.8% (14/26) of C. matruchotii, in 50% (9/18) of Corynebacterium afermentans, 50% (6/12) of Corynebacterium amycolatum, and in 46% (7/15) of Corynebacterium jeikeium strains. Among the five most prevalent strains, we found a high biofilm rate of 54%. The resistance rates to penicillin, clindamycin, ciprofloxacin, rifampicin, tetracycline, and gentamicin were 91.2%, 87.3%, 79.3%, 56.3%, 45.2%, and 39.6%, respectively. All 126 strains were susceptible to vancomycin and linezolid. Conclusion: Non-diphtheriae Corynebacterium strains isolated from blood cultures of hospitalized patients with bacteremia may have multidrug resistance and the ability to produce biofilm. These results emphasize the importance of identifying strains and determining their antimicrobial susceptibility and biofilm production potential.

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“…xerosis, C. jeikeium, C. macginleyi, C. urealyticum, C. pseudodiphtheriticum and C. freneyi, have appeared recently as opportunistic pathogens in immunocompromised patients, in patients with hematologic malignances and in the critically ill (3,4). Corynebacterium striatum colonizes prosthetic devices, catheter tips and ventilator tubes (3), and so most cases where C. striatum is isolated as the culprit pathogen are nosocomial infections involving the exit sites of central venous catheters, conjunctivitis, chorioamnionitis, peritonitis and pyogenic granuloma (1), catheter related blood stream infections (4), pleuropneumonia, meningitis, endocarditis, osteomyelitis and arthritis (5).…”

Section: Discussionmentioning

confidence: 99%

Tracheal Infection due to Corynebacterium striatum in a Female Patient: A Case Report

Xaplanteri¹,

Koletsis²,

Prokakis³

et al. 2019

Respir Case Rep

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Nondiphtherial corynebacteria commonly colonize as normal flora on human skin and mucous membranes, and represent an emerging opportunistic pathogen for immunocompromised or critically ill patients. Corynebacterium striatum has seldom been reported as a human pathogen. Here we present the case of a 62-year-old Caucasian female patient who was previously hospitalized in the Intensive Care Unit, and who attended the emergency department with worsening dyspnea and inspiratory wheezing. The findings of a thorough examination, laboratory tests and imaging were consistent with tracheal stenosis, inflammation related to a previous tracheostomy and a submerged thyroid goiter. A multi-drug resistant C. striatum strain was isolated. The patient was treated with a subtotal thyroidectomy, tracheal resection and tigecycline. Postoperative recovery was complicated by a trauma infection treated with open drainage and antibiotics, and after a long recovery period, the patient was discharged home without further complications.

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Corynebacterium striatumBacteremia Associated with a Catheter-Related Blood Stream Infection

Cited by 17 publications

References 15 publications

Bloodstream and catheter-related infections due to different clones of multidrug-resistant and biofilm producer Corynebacterium striatum

Bloodstream and catheter-related infections due to different clones of multidrug-resistant and biofilm producer Corynebacterium striatum

Biofilm Formation and Antimicrobial Susceptibility of Non-Diphtheriae Corynebacterium Strains Isolated from Blood Cultures: First Report from Turkey

Tracheal Infection due to Corynebacterium striatum in a Female Patient: A Case Report

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