CO₂ Dissociation Curve of Lung Tissue

Rate of disappearance of labeled carbon dioxide from the lungs of humans during breath holding: a method for studying the dynamics of pulmonary CO2 exchange

“…This is a determination with an experimental error which we believe is less than 20%o of the measurement. Other investigators using different techniques have also noted similar variations in these quantities (19,20). Therefore, the pulmonary intracellular CO2 concentration most likely has a wider range of normal values than observed in plasma.…”

“…Techniques for the determination of the CO2 dissociation curve of the lung tissues have included a plethysmographic method (19), direct measurement of the CO2 content in vitro after equilibration with known concentrations of CO2 (20), and methods based on the collection of alveolar gas samples after varying breath holding periods (21,22). In this study a modification of the breath holding methods described by DuBois (21) and Fenn and Dejours (22) was used.…”

The carbon dioxide balance‐sheets of the body: their determination in normal subjects and in cases of congenital heart disease*

“…The lung tissues. Dubois, Fenn & Britt (1953) have drawn attention to the considerable capacity of washed lung tissues for carbon dioxide. These tissues attain almost spontaneous equilibrium with alveolar gas, and form the next system protecting the body against a sudden rise of inspired carbon dioxide tension.…”