<i>Clostridium difficile</i>–Associated Diarrhea after Antibiotic Treatment for Traveler’s Diarrhea

Norman, Francesca; Pérez-Molina, J. Jesús; Ayala, Alejandro; Jiménez, Beatriz C.; Navarro, Miriam; López‐Vélez, Rogelio

doi:10.1086/529380

Cited by 29 publications

(10 citation statements)

References 11 publications

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“…A more legitimate concern is that treatment with antibiotics will modify the microbiota, which may result in the development of C. difficile associated diarrhea or colitis. 96,105 A recent publication reported patients who developed C. difficile colitis following treatment with ciprofloxacin; 106 however, this does not appear to be a common adverse outcome associated with treated TD, and single-dose therapy should significantly minimize this risk.…”

Section: Methodsmentioning

confidence: 99%

Management of Acute Diarrheal Illness During Deployment: A Deployment Health Guideline and Expert Panel Report

et al. 2017

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Background Acute diarrheal illness during deployment causes significant morbidity and loss of duty days. Effective and timely treatment is needed to reduce individual, unit, and health system performance impacts. Methods This critical appraisal of the literature, as part of the development of expert consensus guidelines, asked several key questions related to self-care and healthcare-seeking behavior, antibiotics for self-treatment of travelers’ diarrhea, what antibiotics/regimens should be considered for treatment of acute watery diarrhea and febrile diarrhea and/or dysentery, and when and what laboratory diagnostics should be used to support management of deployment-related travelers’ diarrhea. Studies of acute diarrhea management in military and other travelers were assessed for relevance and quality. Based on this critical appraisal, guideline recommendations were developed and graded by the Expert Panel using good standards in clinical guideline development methodology. Results New definitions for defining the severity of diarrhea during deployment were established. A total of 13 graded recommendations on the topics of prophylaxis, therapy and diagnosis, and follow-up were developed. In addition, four non-graded consensus-based statements were adopted. Conclusions Successful management of acute diarrheal illness during deployment requires action at the provider, population, and commander levels. Strong evidence supports that single-dose antimicrobial therapy is effective in most cases of moderate to severe acute diarrheal illness during deployment. Further studies are needed to address gaps in available knowledge regarding optimal therapies for treatment, prevention, and laboratory testing of acute diarrheal illness.

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Section: Methodsmentioning

confidence: 99%

Management of Acute Diarrheal Illness During Deployment: A Deployment Health Guideline and Expert Panel Report

et al. 2017

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“…Th is may result in the development of C. diffi cile -associated diarrhea or colitis ( 132,145 ). A recent publication reported patients who developed C. diffi cile colitis following treatment with ciprofl oxacin ( 146 ). However, this does not appear to be a common adverse outcome associated with treated TD.…”

Section: Th E Evidence Does Not Support Empiric Anti-microbial Therapymentioning

confidence: 99%

ACG Clinical Guideline: Diagnosis, Treatment, and Prevention of Acute Diarrheal Infections in Adults

Riddle

DuPont

Connor

2016

American Journal of Gastroenterology

319

250

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Acute diarrheal infections are a common health problem globally and among both individuals in the United States and traveling to developing world countries. Multiple modalities including antibiotic and non-antibiotic therapies have been used to address these common infections. Information on treatment, prevention, diagnostics, and the consequences of acute diarrhea infection has emerged and helps to inform clinical management. In this ACG Clinical Guideline, the authors present an evidence-based approach to diagnosis, prevention, and treatment of acute diarrhea infection in both US-based and travel settings. Am J Gastroenterol 2016; 111:602-622; doi: 10.1038/ajg.2016 A follow-up survey where 3,568 respondents (median age 51) were asked at random about illness in the previous 7 days or previous month found that recall bias had an important eff ect on estimates of acute gastrointestinal illness ( 10 ). Using a 7-day exposure window, the estimated incidence of acute diarrhea was 1.6 episodes per person-year, compared with 0.9 episodes per person-year if asked about illness within the preceding month. Other population-based studies from Canada and western European countries using varied methodologies estimate annual incidence between 0.1 to 3.5 episodes per person-year ( 11 18. Antibiotic chemoprophylaxis has moderate to good effectiveness and may be considered in high-risk groups for short-term use. (Strong recommendation, high level of evidence) TD, traveler's diarrhea.

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“…Unusually, C difficile associated disease presents after antibiotic treatment for travellers' diarrhoea. 34 In travellers with diarrhoea that has lasted for 10 days to two weeks or longer, stool samples should be evaluated for Giardia, Cryptosporidium, and other parasites.…”

Section: Combination Treatmentmentioning

confidence: 99%

Management of travellers' diarrhoea

Hill

Ryan

2008

BMJ

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Clostridium difficile–Associated Diarrhea after Antibiotic Treatment for Traveler’s Diarrhea

Cited by 29 publications

References 11 publications

Management of Acute Diarrheal Illness During Deployment: A Deployment Health Guideline and Expert Panel Report

Management of Acute Diarrheal Illness During Deployment: A Deployment Health Guideline and Expert Panel Report

ACG Clinical Guideline: Diagnosis, Treatment, and Prevention of Acute Diarrheal Infections in Adults

Management of travellers' diarrhoea

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