<i>Cinnamomum camphora</i> Seed Kernel Oil Ameliorates Oxidative Stress and Inflammation in Diet‐Induced Obese Rats

Fu, Jing-Li; Zeng, Cheng; Zeng, Zheling; Wang, Baogui; Gong, Deming

doi:10.1111/1750-3841.13271

Cited by 34 publications

(22 citation statements)

References 40 publications

(45 reference statements)

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“…that Cinnamomum camphora seed kernel oil treatment significantly increased the activities of SOD and GSH‐PX in serum in HFD‐induced obese rats when compared to lard and soybean oil groups. [ 38 ]…”

Section: Resultsmentioning

confidence: 99%

Chia Seed Oil Prevents High Fat Diet Induced Hyperlipidemia and Oxidative Stress in Mice

Han

Zhang

et al. 2020

Euro J Lipid Sci & Tech

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Hyperlipidemia is a common cardiovascular disease. At present, the influence of high fat diet (HFD) on this is being explored. Recently, vegetable oils rich in omega‐3 have been reported that can treat hyperlipidemia caused by HFD. However, the effects of chia seed oil (CSO) on HFD‐induced hyperlipidemia and oxidative stress are poorly studied. Hence, in this study, the effects of CSO on hyperlipidemia and oxidative stress induced by HFD in mice are analyzed by various commercial kits, section staining, and protein expression. The results show that CSO decreases body weight and organ index. Meanwhile, CSO reduces serum lipid levels of total cholesterol, triglyceride, and low‐density lipoprotein cholesterol. It can also elevate superoxide dismutase and glutathione peroxidase activities and reduce malondialdehyde content in serum and liver. The results of histopathological analysis prove that CSO improves hepatic steatosis and reduces lipid deposition. Further, the results of western blot demonstrate that CSO upregulates the expression of peroxisome proliferator‐activated receptor alpha and carnitine palmitoyltransferase 1a in the liver. As a result, CSO may be a potential lipid‐lowering oil to prevent and treat HFD‐induced hyperlipidemia and oxidative stress. Practical Applications CSO, as a byproduct of chia seed processing, is a rich source of α‐linolenic acid. This study investigates the effects of CSO on HFD‐induced hyperlipidemia and oxidative stress in mice. It is concluded that dietary CSO can improve the hyperlipidemia in HFD‐induced mice via analysis of lipid parameters, histopathology study of the liver, and lipid metabolism related genes. In addition, supplementation of CSO also can improve the oxidative stress in mice. Therefore, CSO can be used for the prevention of hyperlipidemia and oxidative stress. This research provides a theoretical basis for the comprehensive development and utilization of functional chia seed oil.

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Section: Resultsmentioning

confidence: 99%

Chia Seed Oil Prevents High Fat Diet Induced Hyperlipidemia and Oxidative Stress in Mice

Han

Zhang

et al. 2020

Euro J Lipid Sci & Tech

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“…Oxidative stress occurs when there is an imbalance between the production of reactive metabolites and the activity of antioxidant enzymes. Many studies have shown that oxidative stress is significantly increased in obese patients and animals and causes direct or indirect damage to various organs[31,32]. MDA is a toxic decomposition product of lipid peroxidation degradation, and the MDA content can reflect the degree of oxidative stress and cell damage[33].…”

Section: Discussionmentioning

confidence: 99%

Effect of Sheng-jiang powder on multiple-organ inflammatory injury in acute pancreatitis in rats fed a high-fat diet

Miao

Kang

et al. 2019

WJG

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BACKGROUND Obesity worsens inflammatory organ injury in acute pancreatitis (AP), but there is no effective preventive strategy. Sheng-jiang powder (SJP) has been shown to alleviate multiple-organ inflammatory injury in rats with high-fat diet-induced obesity. Hence, SJP is supposed to have an effect on multiple-organ inflammatory injury in AP in rats fed a high-fat diet. AIM To explore how obesity may contribute to aggravating inflammatory organ injury in AP in rats and observe the effect of SJP on multiple-organ inflammatory injury in AP in rats fed a high-fat diet. METHODS Rats were randomly assigned to a control group (CG), an obese group (OG), and an SJP treatment group (SG), with eight rats per group. The rats in the OG and SG were fed a high-fat diet. From the third week, the rats in the SG were given oral doses of SJP (5 g/kg of body weight). After 12 wk, AP was induced in the three groups. Serum amylase level, body weight, Lee’s index, serum biochemistry parameters, and serum inflammatory cytokine and tissue cytokine levels were assessed, and the tissue histopathological scores were evaluated and compared. RESULTS Compared with the CG, serum triglyceride, total cholesterol, interleukin-6, and interleukin-10 levels were significantly higher in the OG, and serum high-density lipoprotein cholesterol level was significantly lower in the OG. Moreover, enhanced oxidative damage was observed in the pancreas, heart, spleen, lung, intestine, liver, and kidney. Evidence of an imbalanced antioxidant defense system, especially in the pancreas, spleen, and intestine, was observed in the obese AP rats. Compared with the OG, serum high-density lipoprotein cholesterol, interleukin-10, and superoxide dismutase expression levels in the pancreas, spleen, and intestine were increased in the SG. Additionally, SJP intervention led to a decrease in the following parameters: body weight; Lee’s index; serum triglyceride levels; serum total cholesterol levels; malondialdehyde expression levels in the pancreas, heart, spleen, lung, and liver; myeloperoxidase expression levels in the lung; and pathological scores in the liver. CONCLUSION Obesity may aggravate the inflammatory reaction and pathological multiple-organ injury in AP rats, and SJP may alleviate multiple-organ inflammatory injury in AP in rats fed a high-fat diet.

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“…According to the presented findings, it can be speculated that the effects might be caused through inhibiting the expression of proinflammatory genes, such as those for cytokines and cytotoxic-moleculegenerating enzymes, including inducible nitric oxide synthase and cyclooxygenase, via affecting the nuclear factor kappa B pathway. Furthermore, it has been reported that CCEO extracted from seeds could reduce the levels of inflammatory markers (tumor necrosis factor-α, interleukin-6 and P65), probably through upregulating peroxisome proliferator-activated receptor [56]. Moreover, another study reported that 80% ethanol extract of C. camphora leaves exhibits anti-inflammatory effects by phosphorylation of signal transducer, activator of transcription 1 and extracellular signal-regulated kinase 1/2 [57].…”

Section: Anti-inflammatory Actionmentioning

confidence: 98%

“…CCEO has a certain antioxidant capacity, which increases with essential oil concentration [62]. It has been reported that CCEO can reduce the number of reactive oxygenfree radicals via improving the activities of antioxidant enzymes, so as to have an antioxidant effect [56]. In addition, a high concentration of C. osmophloeum Kanehira extract has been proven to have an obvious free-radical scavenging capability [63].…”

Section: Antioxidant Activitymentioning

confidence: 99%

Advances in Biosynthesis and Pharmacological Effects of Cinnamomum camphora (L.) Presl Essential Oil

Zhang

Yang³

et al. 2022

Forests

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Cinnamomum camphora (L.) Presl essential oil (CCEO) is a volatile oil with aroma and is extracted from various tissues of Cinnamomum camphora. It is traditionally used as a spice, preservative, as an anti-inflammatory and for sterilization. Terpenoids are the main active components in CCEO. Based on currently available research, considerable effort is still needed to study the biosynthesis and regulation of terpenoids in CCEO. In this review, the research progress related to terpenoid biosynthesis and bioactivity in CCEO in recent years is summarized, with the data compiled and presented mainly from online resources such as PubMed, Scopus and CNKI in China up to May 2022. The research advances related to key enzymes in the terpenoid biosynthesis pathway are mainly discussed. Previous studies have isolated some genes encoding key enzymes involved in terpenoid biosynthesis; however, among these genes, only a few TPS genes have been verified to catalyze the production of terpenoid synthases at the protein level. Most genes encoding key enzymes have been cloned and isolated, but no transgenic experiments have been carried out to verify gene function. In-depth study of the biosynthesis of terpenoids in CCEO may contribute to a better understanding of the differential accumulation of terpenoids in different types of C. camphora and provide reference for improving terpenoid content in CCEO.

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Cinnamomum camphora Seed Kernel Oil Ameliorates Oxidative Stress and Inflammation in Diet‐Induced Obese Rats

Cited by 34 publications

References 40 publications

Chia Seed Oil Prevents High Fat Diet Induced Hyperlipidemia and Oxidative Stress in Mice

Chia Seed Oil Prevents High Fat Diet Induced Hyperlipidemia and Oxidative Stress in Mice

Effect of Sheng-jiang powder on multiple-organ inflammatory injury in acute pancreatitis in rats fed a high-fat diet

Advances in Biosynthesis and Pharmacological Effects of Cinnamomum camphora (L.) Presl Essential Oil

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