2018
DOI: 10.1101/323907
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

Cerox1 and microRNA-488-3p noncoding RNAs jointly regulate mitochondrial complex I catalytic activity

Abstract: To generate energy efficiently, the cell is uniquely challenged to co-ordinate the abundance of electron transport chain protein subunits expressed from both nuclear and mitochondrial genomes.How an effective stoichiometry of this many constituent subunits is co-ordinated posttranscriptionally remains poorly understood. Here we show that Cerox1, an unusually abundant cytoplasmic long noncoding RNA (lncRNA), modulates the levels of mitochondrial complex I subunit transcripts in a manner that requires binding to… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

0
2
0

Year Published

2018
2018
2022
2022

Publication Types

Select...
2
1

Relationship

0
3

Authors

Journals

citations
Cited by 3 publications
(2 citation statements)
references
References 81 publications
(77 reference statements)
0
2
0
Order By: Relevance
“…Even a slight defect in this pathway has the potential to be detrimental during a process in which cells exit a quiescent state and must undergo a rapid expansion, giving rise to a myriad of differentiated cell types. A recent report has identified the lncRNA here annotated as lnc6689 ( 2810468N07Rik ) also as being a regulator of oxidative phosphorylation in a microRNA-dependent manner (Sirey et al., 2018). Of course, the major questions that remain are a challenge in lncRNA biology more broadly—by what mechanism precisely does this non-coding RNA regulate the differentiation potential and the metabolic capacity of HSCs.…”
Section: Discussionmentioning
confidence: 99%
“…Even a slight defect in this pathway has the potential to be detrimental during a process in which cells exit a quiescent state and must undergo a rapid expansion, giving rise to a myriad of differentiated cell types. A recent report has identified the lncRNA here annotated as lnc6689 ( 2810468N07Rik ) also as being a regulator of oxidative phosphorylation in a microRNA-dependent manner (Sirey et al., 2018). Of course, the major questions that remain are a challenge in lncRNA biology more broadly—by what mechanism precisely does this non-coding RNA regulate the differentiation potential and the metabolic capacity of HSCs.…”
Section: Discussionmentioning
confidence: 99%
“…Even a slight defect in this pathway has the potential to be detrimental during a process where cells exit a quiescent state and have to undergo a rapid expansion, giving rise to a myriad of differentiated cell types. Intriguingly, a recent report has identified the lncRNA here annotated as lnc6689 (2810468N07Rik) also as a regulator of oxidative phosphorylation in a microRNA-dependent manner (Sirey et al, 2018). Of course, the major questions that remain are a challenge in lncRNA biology more broadly, namely by what mechanism precisely does this non-coding RNA regulate the differentiation potential and the metabolic capacity of HSCs.…”
Section: Transcriptomicmentioning
confidence: 99%