<i>Centella asiatica</i>in Dermatology: An Overview

Bylka, Wiesława; Znajdek-Awiżeń, Paulina; Studzińska-Sroka, Elżbieta; Dańczak‐Pazdrowska, Aleksandra; Brzezińska, Małgorzata

doi:10.1002/ptr.5110

Cited by 175 publications

(158 citation statements)

References 30 publications

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“…24 Capryloyl glycine and iris florentine extracts are natural emollients show antibacterial activity and present a sebum-regulator effect and centella asiatica acts repairing dermal tissue, increasing collagen production, and activating blood circulation. 25 …”

Section: Methodsmentioning

confidence: 99%

Importance of Lid Hygiene Before Ocular Surgery: Qualitative and Quantitative Analysis of Eyelid and Conjunctiva Microbiota

Peral

Alonso

García-García

et al. 2016

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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Objective:To evaluate the efficacy of a cleansing eyelid wipe in reducing the microbiota present on the ocular surface before cataract surgery.Methods:A single-center, prospective, single-blind phase IV study was conducted at the University Complutense of Madrid. Forty-five adult patients who were scheduled for ocular surgery after treatment with commercially available eyelid wipes were consecutively enrolled. The study lasted 5 days and the patients were examined at day 0 (D0), day 3 (D3), and day 5 (D5). They received instructions to apply the eyelid wipe only to the eye subject to surgery, using the other eye as a control with no treatment. Lid and conjunctival swabs were taken on each day and microbes identified. Ocular surface microbiota was estimated by measuring the area of the agar plate occupied by the grown colonies with respect to the total available area.Results:Measurements at D3 and D5 showed a percent reduction of 58% and 63%, respectively, in the microbial load on the eyelid in the treated eyes (P=0.0011). There was also a reduction, although nonsignificant, in the microbiota of the conjunctiva of 72% and 69% on D3 and D5, respectively.Conclusions:The degree of microbiota reduction was comparable with that obtained after topical application of antibiotics in other studies. The results suggest the use of these eyelid wipes as a complementary prophylactic method before any ocular surgery.

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Section: Methodsmentioning

confidence: 99%

Importance of Lid Hygiene Before Ocular Surgery: Qualitative and Quantitative Analysis of Eyelid and Conjunctiva Microbiota

Peral

Alonso

García-García

et al. 2016

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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“…C. asiatica extract is widely available in Thailand and cost effective (Taemchuay et al, 2009). Many scientific studies have researched traditional applications of C. asiatica extract (Bylka et al, 2014;Hashim, 2014). C. asiatica extract contains several bioactive compounds, including saponins, essential oils, flavone derivatives, sesquiterpenes, triterpenic acid, and triterpenic steroids (Roy et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

“…Another study has shown that C. asiatica extracts exhibited antioxidant activity and UV protection effects (Hashim et al, 2011). Many beauty products are currently available that incorporate C. asiatica extracts, such as cosmetic creams, hand and body lotions, eye gel, and face mask products (Bylka et al, 2014). A previous study found that C. asiatica extract enlarged hair follicles (Jain and Dass, 2015) and inhibited the activity of 5α-reductase that causes hair loss (Jain et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Enhanced VEGF Expression in Hair Follicle Dermal Papilla Cells by Centella asiatica Linn.

Saansoomchai¹,

Limmongkon²,

Surangkul³

et al. 2018

CMUJNS

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Centella asiatica Linn. (C. asiatica) extract has been shown to possess high antioxidant activity due to its phenols and flavonoids. This study tested the efficacy of 70%-ethanol (EtOH) crude extracts of C. asiatica and its fractions (H 2 O, EtOAc, CH 2 Cl 2 , and hexane) to modulate human follicle dermal papilla cells. In addition, we analyzed the extracts for major phytochemicals as well as free radical scavenging activity. Our results from ABTS and DPPH assays showed that the amounts of phenolic and flavonoid compounds in the extracts were both related to its free radical scavenging activity. While the EtOAc fraction of C. asiatica demonstrated the highest free radical scavenging activity, it was toxic to human follicle dermal papilla cells. The cell viability test was positive when cells were treated with EtOH crude extract and H 2 O fraction. VEGF gene expression, quantified by real-time PCR analysis of the EtOH crude extract, showed a significant level of induction, indicating that the growth promotion effect in human follicle dermal papilla cells was related to VEGF gene expression, which has a positive hair growth stimulating effect. The EtOH crude extract of C. asiatica may offer potential in hair growth promoting products.

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“…Centella asiatica , known by the common name Gotu kola, is a traditional herbal medicine that has been used to exert pharmacological effects in dermatology [19]. The Centella asiatica herb is used in the treatment of skin lesions such as burn wounds, excoriations, or eczema as well as in non-dermatological diseases such as diabetic complications [20], and neurodegenerative disorders [21].…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Effect of Titrated Extract of Centella asiatica in Phthalic Anhydride-Induced Allergic Dermatitis Animal Model

Park

Choi

Son

et al. 2017

IJMS

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Centella asiatica has potent antioxidant and anti-inflammatory properties. However, its anti-dermatitic effect has not yet been reported. In this study, we investigated the anti-dermatitic effects of titrated extract of Centella asiatica (TECA) in a phthalic anhydride (PA)-induced atopic dermatitis (AD) animal model as well as in vitro model. An AD-like lesion was induced by the topical application of five percent PA to the dorsal skin or ear of Hos:HR-1 mouse. After AD induction, 100 μL of 0.2% and 0.4% of TECA (40 μg or 80 μg/cm2) was spread on the dorsum of the ear or back skin three times a week for four weeks. We evaluated dermatitis severity, histopathological changes and changes in protein expression by Western blotting for inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and NF-κB activity, which were determined by electromobility shift assay (EMSA). We also measured TNF-α, IL-1β, IL-6, and IgE concentration in the blood of AD mice by enzyme-linked immunosorbent assay (ELISA). TECA treatment attenuated the development of PA-induced atopic dermatitis. Histological analysis showed that TECA inhibited hyperkeratosis, mast cells and infiltration of inflammatory cells. TECA treatment inhibited expression of iNOS and COX-2, and NF-κB activity as well as the release of TNF-α, IL-1β, IL-6, and IgE. In addition, TECA (1, 2, 5 μg/mL) potently inhibited Lipopolysaccharide (LPS) (1 μg/mL)-induced NO production, expression of iNOS and COX-2, and NF-κB DNA binding activities in RAW264.7 macrophage cells. Our data demonstrated that TECA could be a promising agent for AD by inhibition of NF-κB signaling.

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Centella asiaticain Dermatology: An Overview

Cited by 175 publications

References 30 publications

Importance of Lid Hygiene Before Ocular Surgery: Qualitative and Quantitative Analysis of Eyelid and Conjunctiva Microbiota

Importance of Lid Hygiene Before Ocular Surgery: Qualitative and Quantitative Analysis of Eyelid and Conjunctiva Microbiota

Enhanced VEGF Expression in Hair Follicle Dermal Papilla Cells by Centella asiatica Linn.

Anti-Inflammatory Effect of Titrated Extract of Centella asiatica in Phthalic Anhydride-Induced Allergic Dermatitis Animal Model

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