c-erbB-3 proto-oncogene expression in uterine cervical carcinoma

Abstract

Over-expression of epidermal growth factor receptor (EGFR) and c-erbB-2, in uterine cervical carcinomas, is associated with a worsened prognosis. A third member of this proto-oncogene family, c-erbB-3, has now been identified and its over-expression has been described in a variety of carcinomas. In this immunohistochemical study we have shown that c-erbB-3 is widely expressed in cervical carcinomas, but we have found no association between its over-expression and lymph node status or clinical outcome. In a similar study examining the expression of EGFR and c-erbB-2 it was possible to demonstrate an association between over-expression and a worse prognosis. We conclude, therefore, that it is unlikely that demonstration of c-erbB-3 over-expression will be of any value as a prognostic indicator in carcinoma of the uterine cervix.

Expression of c-erbB3 protein in primary breast carcinomas

“…gastric cancers (Sanidas et al 1993). cenical cancer (Hunt et al 1995. prostate cancer (Poller et al 1992).…”

A 10-Year Histopathologic Audit of Uterine Cervical Biopsies in Warri, Nigeria

“…The terminal lesion, squamous cell carcinoma, on the other hand, occurred chiefly in women in their sixties. Some authors have suggested that age-related changes, especially mistakes in the apoptotic processes, inheritance of peculiar genes or acquisition of genetic defects could also contribute to the development of morbidities of the cervix [44,45].…”

Clinical value of new techniques of gynecological tumor assessment

“…Demonstrable EGFR incervical carcinomas appeared to be associated with a poor prognosis in twostudies(220,221) but was of noprognostic value in another(222). Overexpression ofc‐ erb B‐3 in cervical neoplasms appears to be devoid of any clinicalsignificance(223).…”