“…Nuclear small RNAs promote modification of chromatin, and some changes in histone marks are transgenerationally inherited, also in response to environmental changes (Klosin et al, 2017). The worm's small RNA pools can change transgenerationally in response to multiple environmental challenges such as viral and bacterial infection (Kaletsky et al, 2020;Moore et al, 2019;Rechavi et al, 2011), starvation (Ewe et al, 2020;Rechavi et al, 2014), and stressful temperatures (Ni et al, 2016;Schott et al, 2014). Further, C. elegans actively regulates small RNA inheritance and controls the duration and potency of the transgenerational effects across generations (Houri-Ze'evi et al, 2016;Houri-Zeevi and Rechavi, 2017).…”