2021
DOI: 10.7554/elife.65797
|View full text |Cite
|
Sign up to set email alerts
|

Stress resets ancestral heritable small RNA responses

Abstract: Transgenerational inheritance of small RNAs challenges basic concepts of heredity. In C. elegans nematodes, small RNAs are transmitted across generations to establish a transgenerational memory trace of ancestral environments and distinguish self-genes from non-self-elements. Carryover of aberrant heritable small RNA responses was shown to be maladaptive and to lead to sterility. Here we show that various types of stress (starvation, high temperatures, and high osmolarity) induce resetting of ancestral small R… Show more

Help me understand this report
View preprint versions

Search citation statements

Order By: Relevance

Paper Sections

Select...
5

Citation Types

2
18
0

Year Published

2021
2021
2024
2024

Publication Types

Select...
3
2
1

Relationship

0
6

Authors

Journals

citations
Cited by 62 publications
(23 citation statements)
references
References 132 publications
(216 reference statements)
2
18
0
Order By: Relevance
“…RNAi is a complex and intricate collection of phenomena. RNAi responses are sensitive to environmental conditions (Houri-Zeevi et al, 2021) and susceptible to unexpected outcomes (De-Souza et al, 2019), which in turn could be mediated differently in different genetic backgrounds.…”
Section: Discussionmentioning
confidence: 99%
See 4 more Smart Citations
“…RNAi is a complex and intricate collection of phenomena. RNAi responses are sensitive to environmental conditions (Houri-Zeevi et al, 2021) and susceptible to unexpected outcomes (De-Souza et al, 2019), which in turn could be mediated differently in different genetic backgrounds.…”
Section: Discussionmentioning
confidence: 99%
“…However, the extent of condition-dependent interactions in RNAi may preclude true experimental control. For example, temperature likely plays an unseen hand in RNAi experimentation, given the exquisite sensitivity of C. elegans to temperature (Testa et al, 2020) and the intimate relationship between temperature and other stresses and RNAi (Frézal et al, 2018;Houri-Zeevi et al, 2021;Pagliuso et al, 2021). We controlled environmental temperature by conducting all RNAi assays at 20°C, but RNAi competence may be maximized at different temperatures in different strains.…”
Section: Discussionmentioning
confidence: 99%
See 3 more Smart Citations