Brevundimonas spp: Emerging global opportunistic pathogens

Abstract

Non-fermenting Gram-negative bacteria are problematic in clinical locations, being one of the most prevalent causes of nosocomial infections. Many of these non-fermenting Gram-negative bacteria are opportunistic pathogens that affect patients that are suffering with underlying medical conditions and diseases. Brevundimonas spp., in particular Brevundimonas diminuta and Brevundimonas vesicularis, are a genus of non-fermenting Gram-negative bacteria considered of minor clinical importance. Forty-nine separate instances of infection relating to Brevundimonas spp were found in the scientific literature along with two pseudo-infections. The majority of these instances were infection with Brevundimonas vesicularis (thirty-five cases – 71%). The major condition associated with Brevundimonas spp infection was bacteraemia with seventeen individual cases/outbreaks (35%). This review identified forty-nine examples of Brevundimonas spp. infections have been discussed in the literature. These findings indicate that infection review programs should consider investigation of possible Brevundimonas spp outbreaks if these bacteria are clinically isolated in more than one patient.

Universal Dermal Microbiome in Human Skin

“…Similarly, only a few individual OTUs increased in abundance within the dermis, which included a Methylobacterium species and a Brevundimonas species. These have been recorded as opportunistic pathogens in immunocompromised patients or in those suffering from an underlying disease (20,21), and the dermis may serve as a reservoir for potential pathogens for patients at risk of skin and soft tissue infections. This is in agreement with a growing body of literature suggesting that a lack of regulation of the microbiome by the host (dysbiosis) can lead to previously commensal bacterial species becoming pathogenic (22).…”

Impact of plant genotype and plant habitat in shaping bacterial pathobiome: a comparative study in olive tree

“…Species belonging to Brevundimonas were previously described to confer fitness advantages to host plants, being indicated as potential soil bioremediators 57 and plant growth promotors 58 . However, members of this genus are frequently known as causing severe infections in humans 59,60 , compromising their use in the control of plant diseases. Members of Curtobacterium have been mainly described as plant pathogens 61 and have been found as endophytes on some woody plant species, such as coffee 62 , orange and tangerine 63 .…”

Microbial communities profiling in intensive care units expose limitations in current sanitary standards

“…These clusters include potentially pathogenic genera such as (i) Enterobacter , Staphylococcus , Corynebacterium , and Escherichia _ Shigella ; (ii) Bacteria associated with outside environment (water, soil, and plants), among which Pseudomonas ; (iii) Stenotrophomonas , Acinetobacter , Sphingomonas , and Brevundimonas (which can also cause co-infection with Acinetobacter spp.) [35]. (iv) Enterococcus , Haemophilus , Kocuria , Dietzia , Gemella , and Neisseria ; (v) Micrococcus , Fusobacterium , Prevotella , Delftia , Veillonella , Granulicatella , Rothia , and Streptococcus .…”