<i>Borrelia miyamotoi</i>sensu lato Seroreactivity and Seroprevalence in the Northeastern United States

Krause, Peter J.; Narasimhan, Sukanya; Wormser, Gary P.; Barbour, Alan G.; Platonov, Alexander E.; Brancato, Janna; Lepore, Timothy J.; Dardick, Kenneth R.; Mamula, Mark J.; Rollend, Lindsay; Steeves, Tanner K.; Diuk‐Wasser, Maria A.; Usmani‐Brown, Sahar; Williamson, Phillip; Sarksyan, Denis S.; Fikrig, Erol; Fish, Durland

doi:10.3201/eid2007.131587

Cited by 113 publications

(127 citation statements)

References 29 publications

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“…6 In these studies, 3.2% of patients suspected of Lyme borreliosis and up to almost 10% of patients with confirmed Lyme borreliosis had positive B. miyamotoi serology. Of note, 11% of B. miyamotoi seropositive sera were also positive for B. burgdorferi [80,81]. These findings were confirmed by a GlpQ-Luminex based study in the Netherlands, where a high seroprevalence to B. miyamotoi was found in forestry workers (10%) and patients with Lyme neuroborreliosis (7.4%) compared with 2% in blood donors [82].…”

Section: Reviewmentioning

confidence: 55%

“…Two studies in the USA analyzed the seroprevalence of B. miyamotoi using an enzymelinked immunosorbent assay (ELISA) with confirmatory western blot to detect anti-GlpQ antibodies. In the healthy population, seroprevalence to B. miyamotoi was 0% in a nonendemic region and 1-3.9% in endemic regions (Table 1) [80,81]. One study [38] tested ticks from multiple states but did not clarify prevalences per state.…”

Section: Seroprevalence Of Anti-borrelia Miyamotoi Antibodies In Humansmentioning

confidence: 99%

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Borrelia miyamotoi: a widespread tick-borne relapsing fever spirochete

Wagemakers

Staarink

Sprong

et al. 2015

Trends in Parasitology

155

130

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Section: Reviewmentioning

confidence: 55%

Section: Seroprevalence Of Anti-borrelia Miyamotoi Antibodies In Humansmentioning

confidence: 99%

Borrelia miyamotoi: a widespread tick-borne relapsing fever spirochete

Wagemakers

Staarink

Sprong

et al. 2015

Trends in Parasitology

155

130

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“…The first cases of B. miyamotoi-infected humans were reported in Russia in 2011 [70,71]. A seroprevalence study of healthy residents of the Northeastern US showed (out of 639 samples), 25 (3.9%) people were exposed to B. miyamotoi and were antibody-positive and 60 (9.4%) were positive for B. burgdorferi antibodies [72]. An attachment study allowed transovarially-infected I. scapularis to blood feed on mice for 24, 48, 72, and 73-96 h [40].…”

Section: Borrelia Miyamotoi (Borrelia Myamotoi Disease Borreliosis)mentioning

confidence: 99%

Do Tick Attachment Times Vary between Different Tick-Pathogen Systems?

et al. 2017

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Improvements to risk assessments are needed to enhance our understanding of tick-borne disease epidemiology. We review tick vectors and duration of tick attachment required for pathogen transmission for the following pathogens/toxins and diseases: (1) Anaplasma phagocytophilum (anaplasmosis); (2) Babesia microti (babesiosis); (3) Borrelia burgdorferi (Lyme disease); (4) Southern tick-associated rash illness; (5) Borrelia hermsii (tick-borne relapsing fever); (6) Borrelia parkeri (tick-borne relapsing fever); (7) Borrelia turicatae (tick-borne relapsing fever); (8) Borrelia mayonii; Reported tick attachment times varied (<1 h to seven days) between pathogen/toxin type and tick vector. Not all studies were designed to detect the duration of attachment required for transmission. Knowledge of this important aspect of vector competence is lacking and impairs risk assessment for some tick-borne pathogens.

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“…Ezért magyarországi előfordulásával is számolni kell. Egyelőre sokkal több országban találtak a kullancsokban B. miyamotoi-t, mint amennyiben humán megbetegedést észleltek (1. és 3. táblázat [34][35][36][37][38][39][40]). Ez érthető, hiszen mind a klinikai, mind a laboratóriumi diagnózis nehézkes.…”

Section: Klinikum éS Epidemiológiaunclassified

Borrelia miyamotoi: egy újabb, humán patogén, kullancs által terjesztett, visszatérő lázat okozó baktérium

Szekeres

Lakos²,

Földvári

2017

Orvosi Hetilap

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A Borrelia miyamotoi-t 1995-ben fedezték fel. Ez egy, emberben visszatérő lázat (relapsing fever, febris recurrens) okozó baktérium, amelyet az Ixodes ricinus fajcsoportba tartozó kullancsok terjesztenek. Ez a kórokozó genetikailag, járványtanilag és az általa okozott kórkép tekintetében is különbözik a szintén kullancsok által terjesztett Borrelia burgdorferi sensu lato (Lyme spirochaeta) baktériumoktól. Eddig világszerte több mint 50 heveny lázas megbetegedésben szenvedő páciensből mutatták már ki, ezenfelül három tumoros betegben meningoencephalitist okozott ez a kórokozó. A különböző élőhelyeken található kullancsok és gazdáik fertőzöttségének mértéke, eloszlása és a fertőzés mechanizmusa nem tisztázott még. A B. miyamotoi elsősorban lázat okoz, ami miatt más, kullancsok által terjesztett fertőzésekkel is összetéveszthető. Az utóbbi évek intenzív vizsgálatai alapján nemcsak egyre több földrajzi régióból mutatják ki ezt a baktériumot kullancsokból, de folyamatosan növekszik a publikált humán esetszám is, ezért növek-vő jelentőségű (emerging) kórokozóként tartják számon. Irodalmi áttekintésünkben összegezzük az eddigi ismereteinket a Borrelia miyamotoi-val kapcsolatban. Orv Hetil. 2017; 158(29): 1124-1130. Kulcsszavak: Borrelia miyamotoi, kullancs, visszatérő láz, kullancs által terjesztett fertőzések Borrelia miyamotoi: a recently identified human pathogenic tick-borne relapsing fever spirocheteBorrelia miyamotoi is a recently described relapsing fever spirochete transmitted by ticks of the Ixodes ricinus complex. This pathogen is different from Borrelia burgdorferi sensu lato (the Lyme borreliosis spirochetes) in its epidemiology, ecology and also genetics. Over 50 patients have been described worldwide with Borrelia miyamotoi disease, and three immunocompromised patients were reported with neurological symptoms. Our knowledge about Borrelia miyamotoi infection in ticks and its distribution in different habitats and also the mechanism of the infection is limited. The most common symptom is fever; thus it can be easily confused with other tick-borne diseases. Due to the intensive research in recent years, Borrelia miyamotoi infection in ticks and hosts has been reported from different regions and also the number of patients is increasing, thus this bacterium is considered as an emerging pathogen. In this literature review we would like to summarize the available knowledge about this spirochete.

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Borrelia miyamotoisensu lato Seroreactivity and Seroprevalence in the Northeastern United States

Abstract: Serum from �%^4% of residents was positive for infection, compared with �%^9% for B. burgdorferi.

Cited by 113 publications

References 29 publications

Borrelia miyamotoi: a widespread tick-borne relapsing fever spirochete

Borrelia miyamotoi: a widespread tick-borne relapsing fever spirochete

Do Tick Attachment Times Vary between Different Tick-Pathogen Systems?

Borrelia miyamotoi: egy újabb, humán patogén, kullancs által terjesztett, visszatérő lázat okozó baktérium

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