<i>Bifidobacterium longum</i>CCFM752 prevented hypertension and aortic lesion, improved antioxidative ability, and regulated the gut microbiome in spontaneously hypertensive rats

Liu, Wenwei; Wang, Yusheng; Fang, Zhifeng; Wang, Hongchao; Zhu, Jinlin; Zhai, Qixiao; Zhao, Jianxin; Zhang, Hao; Chen, Wei

doi:10.1039/d1fo04446j

Cited by 11 publications

(6 citation statements)

References 57 publications

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“…Bifidobacterium was found to be associated with a lower risk of PE, which is consistent with the results of our study [ 18 , 20 ]. Bifidobacterium , as a probiotic, has been widely reported to have a protective effect on cardiovascular [ 47 ] and metabolic diseases [ 48 ]. Consistent with previous studies [ 20 , 21 , 45 ], we also found that Lachnospiraceae (NK4A136 group) , butyrate-producing bacteria [ 49 ], reduced the risk of PE.…”

Section: Discussionmentioning

confidence: 99%

Association between gut microbiota and preeclampsia-eclampsia: a two-sample Mendelian randomization study

Wang

Guo

et al. 2022

BMC Med

247

138

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Background Several recent observational studies have reported that gut microbiota composition is associated with preeclampsia. However, the causal effect of gut microbiota on preeclampsia-eclampsia is unknown. Methods A two-sample Mendelian randomization study was performed using the summary statistics of gut microbiota from the largest available genome-wide association study meta-analysis (n=13,266) conducted by the MiBioGen consortium. The summary statistics of preeclampsia-eclampsia were obtained from the FinnGen consortium R7 release data (5731 cases and 160,670 controls). Inverse variance weighted, maximum likelihood, MR-Egger, weighted median, weighted model, MR-PRESSO, and cML-MA were used to examine the causal association between gut microbiota and preeclampsia-eclampsia. Reverse Mendelian randomization analysis was performed on the bacteria that were found to be causally associated with preeclampsia-eclampsia in forward Mendelian randomization analysis. Cochran’s Q statistics were used to quantify the heterogeneity of instrumental variables. Results Inverse variance weighted estimates suggested that Bifidobacterium had a protective effect on preeclampsia-eclampsia (odds ratio = 0.76, 95% confidence interval: 0.64–0.89, P = 8.03 × 10−4). In addition, Collinsella (odds ratio = 0.77, 95% confidence interval: 0.60–0.98, P = 0.03), Enterorhabdus (odds ratio = 0.76, 95% confidence interval: 0.62–0.93, P = 8.76 × 10−3), Eubacterium (ventriosum group) (odds ratio = 0.76, 95% confidence interval: 0.63–0.91, P = 2.43 × 10−3), Lachnospiraceae (NK4A136 group) (odds ratio = 0.77, 95% confidence interval: 0.65–0.92, P = 3.77 × 10−3), and Tyzzerella 3 (odds ratio = 0.85, 95% confidence interval: 0.74–0.97, P = 0.01) presented a suggestive association with preeclampsia-eclampsia. According to the results of reverse MR analysis, no significant causal effect of preeclampsia-eclampsia was found on gut microbiota. No significant heterogeneity of instrumental variables or horizontal pleiotropy was found. Conclusions This two-sample Mendelian randomization study found that Bifidobacterium was causally associated with preeclampsia-eclampsia. Further randomized controlled trials are needed to clarify the protective effect of probiotics on preeclampsia-eclampsia and their specific protective mechanisms.

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Section: Discussionmentioning

confidence: 99%

Association between gut microbiota and preeclampsia-eclampsia: a two-sample Mendelian randomization study

Wang

Guo

et al. 2022

BMC Med

247

138

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“…The present study found that oxidative stress did exist in SHR, and irbesartan, L. johnsonii or L. reuteri could significantly restore related oxides such as MDA, SOD, GSH, and CAT. Recent study has shown that Lactobacillus was positively associated with serum CAT activity, while Turicibacter was negatively connected with serum CAT activity [33]. These results suggested that the irbesartan decreased inflammatory cytokines and oxidative stress by regulating gut microbial ecology.…”

Section: Discussionmentioning

confidence: 85%

Lactobacillus induced by irbesartan on spontaneously hypertensive rat contribute to its antihypertensive effect

Xiong,

He,

Chen

et al. 2023

Journal of Hypertension

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Objective: Hypertension is linked to gut dysbiosis. Here, the impact of the angiotensin receptor antagonist irbesartan on the gut microbiota of spontaneously hypertensive rats (SHR) were investigated. In addition, we assessed their contribution to its antihypertensive effect. Methods: Eight-week-old Wistar–Kyoto (WKY) rats and SHR were administered irbesartan for 8 weeks. Fecal microbiota transplantation (FMT) was performed from SHR treated with irbesartan or untreated SHR to recipient untreated SHR. The preventive effect of Lactobacillus on hypertension in SHR was evaluated. Blood pressure (BP) was calculated using a tail-sleeve sphygmomanometer. To better assess the composition of the gut microbiota, the V3–V4 region of the 16S rRNA gene was amplified while short-chain fatty acids (SCFAs) in feces were tested by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). Results: Irbesartan restored gut dysbiosis, increased the abundance of Lactobacillus, and improved anti-inflammatory ability, antioxidative ability, intestinal integrity, and intestinal inflammation in SHR. The microbiota in SHR-treated irbesartan could reduce BP and improve antioxidative ability and gut integrity in SHR. Lactobacillus johnsonii (L. johnsonii) and Lactobacillus reuteri (L. reuteri) reduced BP, restored gut dysbiosis and improved anti-inflammatory ability, antioxidative ability, intestinal integrity in SHR. Most notably, irbesartan, L. johnsonii, and L. reuteri can significantly increase SCFA content in SHR feces. Conclusion: The current study demonstrated that irbesartan treatment ameliorated gut dysbiosis in SHR. Irbesartan induced alterations in gut microbiota, with increased prevalence of Lactobacillus.

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“…Beyond that, other probiotics like bifidobacterium has been found worked in cardiovascular models. Lu et al 94 reported that the growth of HTN and vascular remodeling in SHR was inhibited by Bifidobacterium longum CCFM752. Nevertheless, these abilities have yet to be confirmed in an OSA‐related HTN model.…”

Section: Therapeutic Considerationsmentioning

confidence: 99%

Recent progresses in gut microbiome mediates obstructive sleep apnea‐induced cardiovascular diseases

Zhang,

et al. 2024

FASEB BioAdvances

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Obstructive sleep apnea (OSA) is a multifactorial sleep disorder with a high prevalence in the general population. OSA is associated with an increased risk of developing cardiovascular diseases (CVDs), particularly hypertension, and is linked to worse outcomes. Although the correlation between OSA and CVDs is firmly established, the mechanisms are poorly understood. Continuous positive airway pressure is primary treatment for OSA reducing cardiovascular risk effectively, while is limited by inadequate compliance. Moreover, alternative treatments for cardiovascular complications in OSA are currently not available. Recently, there has been considerable attention on the significant correlation between gut microbiome and pathophysiological changes in OSA. Furthermore, gut microbiome has a significant impact on the cardiovascular complications that arise from OSA. Nevertheless, a detailed understanding of this association is lacking. This review examines recent advancements to clarify the link between the gut microbiome, OSA, and OSA‐related CVDs, with a specific focus on hypertension, and also explores potential health advantages of adjuvant therapy that targets the gut microbiome in OSA.

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Bifidobacterium longumCCFM752 prevented hypertension and aortic lesion, improved antioxidative ability, and regulated the gut microbiome in spontaneously hypertensive rats

Abstract: Oxidative stress and gut dysbiosis are important risk factors for hypertension. In this study, the preventive effect of Bifidobacterium longum CCFM752 (CCFM752) on hypertension was evaluated. 5-week-old spontaneously hypertensive rats...

Cited by 11 publications

References 57 publications

Association between gut microbiota and preeclampsia-eclampsia: a two-sample Mendelian randomization study

Association between gut microbiota and preeclampsia-eclampsia: a two-sample Mendelian randomization study

Lactobacillus induced by irbesartan on spontaneously hypertensive rat contribute to its antihypertensive effect

Recent progresses in gut microbiome mediates obstructive sleep apnea‐induced cardiovascular diseases

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