Lactobacillus induced by irbesartan on spontaneously hypertensive rat contribute to its antihypertensive effect
Yanling Xiong,
Yanping He,
Zhi Chen
et al.
Abstract:Objective:
Hypertension is linked to gut dysbiosis. Here, the impact of the angiotensin receptor antagonist irbesartan on the gut microbiota of spontaneously hypertensive rats (SHR) were investigated. In addition, we assessed their contribution to its antihypertensive effect.
Methods:
Eight-week-old Wistar–Kyoto (WKY) rats and SHR were administered irbesartan for 8 weeks. Fecal microbiota transplantation (FMT) was performed from SHR treated with irbesar… Show more
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