BBOX1‐AS1 contributes to colorectal cancer progression by sponging hsa‐miR‐361‐3p and targeting SH2B1

Liu, Jiasheng; Xiao, Zhe; Wang, Xufeng; Luo, Jianfei

doi:10.1002/2211-5463.12802

Cited by 34 publications

(45 citation statements)

References 24 publications

(25 reference statements)

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“…In recent years, SH2B1 has been found to be highly expressed in some cancers and has been demonstrated to be associated with the development of cancers [4][5][6][7][8]. Our results consistently suggested that SH2B1 might play an important role in the progression of CRC.…”

Section: Discussionsupporting

confidence: 81%

“…In vitro experiment, SH2B1 was found to be highly expressed in CRC cell lines and its overexpression was related to CRC cell progression. [8,10] The objective of this study is to indicate the expression of SH2B1 in different tumor tissues from CRC patients and to clarify if SH2B1 expression in tumor tissues is prognostic and/or predictive for CRC. This study should be helpful for the prediction and targeted treatment of CRC.…”

mentioning

confidence: 99%

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High expression of SH2B adaptor protein 1 (SH2B1) indicates poor prognosis in colorectal cancer

Zhang¹,

Xu²,

Pan³

et al. 2021

neo

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SH2B1, an adaptor protein associated with obesity, is closely related to the occurrence and development of a variety of tumors. To investigate the clinical significance of SH2B1 in colorectal cancer (CRC), expression of SH2B1 in colorectal normal tissues, adenomas, paracarcinoma tissues, carcinoma tissues, and metastatic tissues from 1003 CRC patients was detected by immunohistochemistry (IHC). The prediction power of SH2B1 for CRC prognosis was evaluated by Kaplan Meier survival analysis and Cox regression model. Results revealed the expression o f SH2B1 in carcinoma tissues was significantly higher than that in other tissues. High expression of SH2B1 was an independent risk factor for both disease-free survival (DFS) and disease-specific survival (DSS) and predicted unfavorable prognosis of CRC as well as poor chemotherapeutic response. Conclusively, SH2B1 can serve as an effective predictor for CRC survival and chemotherapeutic outcomes.

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Section: Discussionsupporting

confidence: 81%

mentioning

confidence: 99%

High expression of SH2B adaptor protein 1 (SH2B1) indicates poor prognosis in colorectal cancer

Zhang¹,

Xu²,

Pan³

et al. 2021

neo

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“…The ROC curve analysis of miR-361-3p yielded area under the curve of 0.921 (95% CI 0.806-1) for discriminating VRL from vitreous opacity with uveitis, indicating diagnostic value. miR-361-3p has been reported to be modulated in solid tumors such as colon, lung, pancreas, cervical, thyroid, cervical cancer and retinoblastoma [26][27][28][29][30][31]. These findings allow us to speculate that increased vitreous miR-361-3p may contribute to carcinogenesis in VRL patients, and the performance of vitreous miR-361-3p needs further validation before clinical use.…”

Section: Discussionmentioning

confidence: 84%

High-Throughput MicroRNA Profiling of Vitreoretinal Lymphoma: Vitreous and Serum MicroRNA Profiles Distinct from Uveitis

Minezaki

Usui

Asakage

et al. 2020

JCM

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Purpose: Vitreoretinal lymphoma (VRL) is a non-Hodgkin lymphoma of the diffuse large B cell type (DLBCL), which is an aggressive cancer causing central nervous system related mortality. The pathogenesis of VRL is largely unknown. The role of microRNAs (miRNAs) has recently acquired remarkable importance in the pathogenesis of many diseases including cancers. Furthermore, miRNAs have shown promise as diagnostic and prognostic markers of cancers. In this study, we aimed to identify differentially expressed miRNAs and pathways in the vitreous and serum of patients with VRL and to investigate the pathogenesis of the disease. Materials and Methods: Vitreous and serum samples were obtained from 14 patients with VRL and from controls comprising 40 patients with uveitis, 12 with macular hole, 14 with epiretinal membrane, 12 healthy individuals. The expression levels of 2565 miRNAs in serum and vitreous samples were analyzed. Results: Expression of the miRNAs correlated significantly with the extracellular matrix (ECM) ‒receptor interaction pathway in VRL. Analyses showed that miR-326 was a key driver of B-cell proliferation, and miR-6513-3p could discriminate VRL from uveitis. MiR-1236-3p correlated with vitreous interleukin (IL)-10 concentrations. Machine learning analysis identified miR-361-3p expression as a discriminator between VRL and uveitis. Conclusions: Our findings demonstrate that aberrant microRNA expression in VRL may affect the expression of genes in a variety of cancer-related pathways. The altered serum miRNAs may discriminate VRL from uveitis, and serum miR-6513-3p has the potential to serve as an auxiliary tool for the diagnosis of VRL.

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“…A series of papers have been published that uncovered the role of SH2B1 in the occurrence, progression, and worsening of colorectal cancer, gastric cancer, and NSCLC. 19 , 27 , 29 In conclusion, we identified a novel biomarker of the EC progression circRNA hsa_circ_0075960, which served as a sponger of miR-361-3p to regulate the expression of SH2B1.…”

Section: Discussionmentioning

confidence: 91%

“…In addition, miR-361-3p was found to contribute to the progression of various tumors. [16][17][18][19][20] In order to identify the interaction between hsa_circ_0075960 and miR-361-3p, we mutated the possible binding sites of hsa_circ_0075960 and miR-361-3p. The luciferase assay exhibited that the miR-361-3p mimics reduced the luciferase activity of the hsa_circ_0075960 WT reporter group rather than that of the hsa_circ_0075960 MUT group, indicating that miR-361-3p bond to hsa_circ_0075960 directly ( Figure 3B).…”

Section: Hsa_circ_0075960 Bond Negatively Regulated Mir-361-3pmentioning

confidence: 99%

Hsa_circ_0075960 Serves as a Sponge for miR-361-3p/SH2B1 in Endometrial Carcinoma

Ren

Tian

et al. 2020

Technol Cancer Res Treat

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Although the cases of endometrial carcinoma (EC) is gradually increasing across the world, its etiology and pathogenesis remain unknown. The present study is the first to define the role and biological function of circRNA hsa_circ_0075960 in the development and progression of EC. We first determined that hsa_circ_0075960 is aberrantly expressed in EC cells. Then, we uncovered that the downregulation of hsa_circ_0075960 suppressed cell proliferation and promoted cell apoptosis of EC cells, suggesting that hsa_circ_0075960 could inhibit the progression of EC in vitro. In addition, we identified that miR-361-3p was the direct target of hsa_circ_0075960. Further analysis revealed that hsa_circ_0075960 affected the development of EC via sponging miR-361-3p. Interestingly, we verified that the level of SH2B1 was controlled by the downregulation of hsa_circ_0075960 and that the negative effect caused by hsa_circ_0075960 could be reversed via miR-361-3p inhibition. Our cumulative results revealed that the novel tumor regulator hsa_circ_0075960 functioned as a sponge for miR-361-3p/SH2B1 in EC cells and regulated the progression of EC through the modulation of miR-361-3p.

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BBOX1‐AS1 contributes to colorectal cancer progression by sponging hsa‐miR‐361‐3p and targeting SH2B1

Cited by 34 publications

References 24 publications

High expression of SH2B adaptor protein 1 (SH2B1) indicates poor prognosis in colorectal cancer

High expression of SH2B adaptor protein 1 (SH2B1) indicates poor prognosis in colorectal cancer

High-Throughput MicroRNA Profiling of Vitreoretinal Lymphoma: Vitreous and Serum MicroRNA Profiles Distinct from Uveitis

Hsa_circ_0075960 Serves as a Sponge for miR-361-3p/SH2B1 in Endometrial Carcinoma

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