<i>Bartonella henselae</i>as a cause of acute-onset febrile illness in cats

Breitschwerdt, Edward B.; Broadhurst, Jack J; Cherry, Natalie A.

doi:10.1177/2055116915600454

Cited by 12 publications

(31 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, it is very difficult to prove disease associations in cats in the field because of the high prevalence rates in nonclinical carriers. In research cats that are infected by exposure to C. felis , fever, endocarditis and myocarditis are the most common disease manifestations . As discussed for dogs, additional case‐controlled, prospective studies are needed in cats …”

Section: Clinical Findingsmentioning

confidence: 99%

“…Thrombocytopenia is found in approximately half and eosinophilia in approximately one third of infected dogs, and monocytosis frequently occurs in association with Bartonella endocarditis . Haematological abnormalities have been rarely reported in cats, but similar to dogs, a subset of Bartonella ‐infected cats are neutropenic or mildly thromobocytopenic …”

Section: Clinical Findingsmentioning

confidence: 99%

“…From a zoonotic and comparative infectious diseases perspective, most dogs, some cats and many Bartonella bacteraemic human patients do not have antibodies against the infecting Bartonella sp. found in their blood or tissues . Therefore, antibody testing remains highly insensitive.…”

Section: Serology Isolation and Molecular Detection Of Bartonella Spmentioning

confidence: 99%

“…If seroreactive at the time of initial diagnosis, serum antibody titres decrease rapidly (3–6 months) and are generally no longer detectable in cats and dogs that recover following antimicrobial therapy . Interestingly, seronegative animals with a history of chronic illnesses (presumably chronic Bartonella infection) can seroconvert within days to weeks after initiating antibiotic treatment, thereby providing support for a diagnosis of bartonellosis . Therefore, post‐treatment serology may be a useful adjunct to BAPGM enrichment PCR to determine if a patient is infected (i.e.…”

Section: Therapymentioning

confidence: 99%

“…Whether there is clinical benefit to follow serological or molecular assay results in cats has not been widely studied, but most treated cats do not become seronegative in the short term. Bacteraemia can resolve after treatment or resolve spontaneously in some cats, whereas other cats remain bacteraemic despite 4–6 weeks of antibiotic (documented for several antibiotic regimens) administration, and despite resolution of clinical abnormalities (such as lethargy, inappetence and fever) …”

Section: Therapymentioning

confidence: 99%

See 4 more Smart Citations

Bartonellosis, One Health and all creatures great and small

Breitschwerdt

2017

Veterinary Dermatology

113

118

View full text Add to dashboard Cite

Background Bartonellosis is a zoonotic infectious disease of worldwide distribution, caused by an expanding number of recently discovered Bartonella spp. Objectives This review serves as an update on comparative medical aspects of this disease, including the epidemiology, pathogenesis, clinical diagnosis, treatment and challenges. Results Of comparative medical importance, Bartonella spp. are transmitted by several arthropod vectors, including fleas, keds, lice, sand flies, ticks and, potentially, mites and spiders. Prior to 1990, there was only one named Bartonella species (B. bacilliformis), whereas there are now over 36, of which 17 have been associated with an expanding spectrum of animal and human diseases. Recent advances in diagnostic techniques have facilitated documentation of chronic bloodstream and dermatological infections with Bartonella spp. in healthy and sick animals, in human blood donors, and in immunocompetent and immunocompromised human patients. The field of Bartonella research remains in its infancy and is rich in questions, for which patient relevant answers are badly needed. Directed Bartonella research could substantially reduce a spectrum of chronic and debilitating animal and human diseases, and thereby reduce suffering throughout the world. Conclusion A One Health approach to this emerging infectious disease is clearly needed to define disease manifestations, to establish the comparative infectious disease pathogenesis of this stealth pathogen, to validate effective treatment regimens and to prevent zoonotic disease transmission.

show abstract

Section: Clinical Findingsmentioning

confidence: 99%

Section: Clinical Findingsmentioning

confidence: 99%

Section: Serology Isolation and Molecular Detection Of Bartonella Spmentioning

confidence: 99%

Section: Therapymentioning

confidence: 99%

Section: Therapymentioning

confidence: 99%

See 3 more Smart Citations

Bartonellosis, One Health and all creatures great and small

Breitschwerdt

2017

Veterinary Dermatology

113

118

View full text Add to dashboard Cite

show abstract

Bartonellosis, One Health and all creatures great and small

Breitschwerdt

2017

Advances in Veterinary Dermatology

View full text Add to dashboard Cite

Background -Bartonellosis is a zoonotic infectious disease of worldwide distribution, caused by an expanding number of recently discovered Bartonella spp.Objectives -This review serves as an update on comparative medical aspects of this disease, including the epidemiology, pathogenesis, clinical diagnosis, treatment and challenges.Results -Of comparative medical importance, Bartonella spp. are transmitted by several arthropod vectors, including fleas, keds, lice, sand flies, ticks and, potentially, mites and spiders. Prior to 1990, there was only one named Bartonella species (B. bacilliformis), whereas there are now over 36, of which 17 have been associated with an expanding spectrum of animal and human diseases. Recent advances in diagnostic techniques have facilitated documentation of chronic bloodstream and dermatological infections with Bartonella spp. in healthy and sick animals, in human blood donors, and in immunocompetent and immunocompromised human patients. The field of Bartonella research remains in its infancy and is rich in questions, for which patient relevant answers are badly needed. Directed Bartonella research could substantially reduce a spectrum of chronic and debilitating animal and human diseases, and thereby reduce suffering throughout the world.

show abstract

Associations between presence of Bartonella species deoxyribonucleic acid and complete blood cell count and serum biochemical changes in client‐owned cats

Williams

Rao

Braff

et al. 2022

Veterinary Internal Medicne

View full text Add to dashboard Cite

Background Infection with Bartonella species is common in cats but reported effects of bacteremia on laboratory variables differ. Objectives Evaluate for associations between Bartonella bacteremia and CBC and serum biochemical changes in sick and healthy cats throughout the United States. Animals A total of 3964 client‐owned cats. Methods Retrospective cohort study using submissions to a commercial laboratory between 2011 and 2017. Serum biochemistry and CBC abnormalities (categorized as above or below reference intervals), age, and location (high‐ or low‐risk state for Ctenocephalides felis) in presumed healthy and sick cats were evaluated for associations with presence of Bartonella spp. DNA, detected by PCR. Univariate and multivariable logistic regression analyses were performed. Results Bartonella spp. DNA was amplified from 127 (3.2%) of 3964 cats; 126 (99.2%) of 127 were from high flea risk states and 121 (95.3%) of 127 were presumed sick. Fever of unknown origin was the most common PCR panel requested. In the multivariable analysis, neutrophilia, decreased ALP activity, clinical status (presumed sick), and young age (≤2 years) each were positively associated whereas neutropenia and hyperproteinemia both were negatively associated with Bartonella spp. bacteremia. Presence of Bartonella spp. DNA had no association with test results for other infectious disease agents. Conclusions and Clinical Importance In both healthy and sick cats, active Bartonella infections had minimal association with clinically relevant laboratory abnormalities. However, based on these results, in areas considered high risk for C. felis, active infection with Bartonella spp. is a reasonable differential diagnosis for cats presented with unexplained fever and neutrophilia, particularly if the cat is young.

show abstract

Bartonella henselaeas a cause of acute-onset febrile illness in cats

Cited by 12 publications

References 44 publications

Bartonellosis, One Health and all creatures great and small

Bartonellosis, One Health and all creatures great and small

Bartonellosis, One Health and all creatures great and small

Associations between presence of Bartonella species deoxyribonucleic acid and complete blood cell count and serum biochemical changes in client‐owned cats

Contact Info

Product

Resources

About