<i>Bartonella henselae</i> and <i>Borrelia burgdorferi</i> Infections of the Central Nervous System

Podsiadły, Edyta; Chmielewski, Tomasz; Tylewska-Wierzbanowska, Stanisława

doi:10.1111/j.1749-6632.2003.tb07400.x

Cited by 35 publications

(31 citation statements)

References 4 publications

(3 reference statements)

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“…For example, patients with ongoing symptoms attributed to chronic Lyme disease have been shown to be co-infected with Bartonella sp. [16,35] or Babesia sp. and Ehrlichia sp.…”

Section: Discussionmentioning

confidence: 99%

“…Babesia sp., the causative agents of babesiosis are transmitted by ixodid ticks and are capable of infecting a wide variety of vertebrate hosts including humans and cattle [20]. Co-infections of Borrelia burgdorferi sensu lato with Bartonella henselae have been found in patients presenting symptoms of atypical neuroborreliosis [16,35] while mice have been found to be naturally co-infected with Borrelia burgdorferi, Babesia microti and a novel Bartonella sp. in the USA [21].…”

Section: Introductionmentioning

confidence: 99%

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Evidence of Bartonella sp. in questing adult and nymphal Ixodes ricinus ticks from France and co-infection with Borrelia burgdorferi sensu lato and Babesia sp.

et al. 2005

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-Ticks are known vectors for a wide range of pathogenic microorganisms. Their role in the transmission of some others is so far only suspected. Ticks can transmit multiple pathogens, however, little is known about the co-existence of these pathogens within questing ticks. We looked for the presence of DNA from three micro-organisms, Bartonella sp., Borrelia burgdorferi sensu lato and Babesia sp. which are known or suspected tick-borne pathogens, using a cohort of 92 questing Ixodes ricinus ticks collected from pastures in northern France. DNA was extracted from each individual tick and the presence of the three pathogens was investigated using Polymerase Chain Reaction (PCR) amplification. Nine among 92 samples (9.8%) demonstrated PCR products using Bartonella specific primers, 3 among 92 (3.3%) using Borrelia burgdorferi sensu lato specific primers and 19 among 92 (20.6%) using Babesia specific primers. Seven among 92 samples (7.6%) were PCR positive for at least two of the pathogens and one sample was positive for all three. Adult ticks (12/18; 67%) showed significantly higher infection rates compared to nymphs (11/74; 15%) for all three pathogens (P < 0.001). This study is the demonstration of the simultaneous presence of Bartonella sp., Borrelia burgdorferi sensu lato and Babesia sp. in questing Ixodes ricinus ticks. questing ticks / co-infection / PCR detection

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“…For example, patients with ongoing symptoms attributed to chronic Lyme disease have been shown to be co-infected with Bartonella sp. [16,35] or Babesia sp. and Ehrlichia sp.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evidence of Bartonella sp. in questing adult and nymphal Ixodes ricinus ticks from France and co-infection with Borrelia burgdorferi sensu lato and Babesia sp.

et al. 2005

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“…(11,12,19,23,25,28,29). This suggestion was based on indirect data for detection of bacterial DNA in ticks (18,19,24), humans exposed to tick bites (30), or serologic evidence of co-infection of humans with pathogens known to be transmitted by ticks (11,36).…”

Section: Discussionmentioning

confidence: 99%

“…In humans, several case studies have reported patients with concurrent Bartonella seropositivity and detection of Bartonella spp. DNA in their blood, along with B. burgdorferi infection of the central nervous system after tick bites (11,29). Moreover, Bartonella spp.…”

mentioning

confidence: 99%

Transmission ofBartonella henselaebyIxodes ricinus

Cotté

Bonnet

Rhun

et al. 2008

Emerg. Infect. Dis.

224

198

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Bartonella spp. are facultative intracellular bacteria associated with several emerging diseases in humans and animals. B. henselae causes cat-scratch disease and is increasingly associated with several other syndromes, particularly ocular infections and endocarditis. Cats are the main reservoir for B. henselae and the bacteria are transmitted to cats by cat fl eas. However, new potential vectors are suspected of transmitting B. henselae, in particular, Ixodes ricinus, the most abundant ixodid tick that bites humans in western Europe. We used a membranefeeding technique to infect I. ricinus with B. henselae and demonstrate transmission of B. henselae within I. ricinus across developmental stages, migration or multiplication of B. henselae in salivary glands after a second meal, and transmission of viable and infective B. henselae from ticks to blood. These results provide evidence that I. ricinus is a competent vector for B. henselae.

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“…There have been descriptions of the simultaneous presence of Borrelia and Chlamydia in the synovium of patients with Lyme arthritis (39). Also, concurrent infection of the central nervous system by B. burgdorferi and Bartonella henselae has been recently described, representing a novel tick-borne disease complex (40,41).…”

Section: Is Lyme Disease-like Syndrome a New Tick-borne Disease?mentioning

confidence: 99%

Description of Lyme disease-like syndrome in Brazil: is it a new tick borne disease or Lyme disease variation?

Mantovani

Costa²,

Gauditano

et al. 2007

Braz J Med Biol Res

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An emerging clinical entity that reproduces clinical manifestations similar to those observed in Lyme disease (LD) has been recently under discussion in Brazil. Due to etiological and laboratory particularities it is named LD-like syndrome or LD imitator syndrome. The condition is considered to be a zoonosis transmitted by ticks of the genus Amblyomma, possibly caused by interaction of multiple fastidious microorganisms originating a protean clinical picture, including neurological, osteoarticular and erythema migrans-like lesions. When peripheral blood of patients with LD-like syndrome is viewed under a dark-field microscope, mobile uncultivable spirochete-like bacteria are observed. PCR carried out with specific or conservative primers to recognize Borrelia burgdorferi sensu stricto or the genus Borrelia has been negative in ticks and in biological samples. Two different procedures, respectively involving hematoxylin and eosin staining of cerebrospinal fluid and electron microscopy analysis of blood, have revealed spirochetes not belonging to the genera Borrelia, Leptospira or Treponema. Surprisingly, co-infection with microorganisms resembling Mycoplasma and Chlamydia was observed on one occasion by electron microscopy analysis. We discuss here the possible existence of a new tick-borne disease in Brazil imitating LD, except for a higher frequency of recurrence episodes observed along prolonged clinical follow-up.

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Bartonella henselae and Borrelia burgdorferi Infections of the Central Nervous System

Cited by 35 publications

References 4 publications

Evidence of Bartonella sp. in questing adult and nymphal Ixodes ricinus ticks from France and co-infection with Borrelia burgdorferi sensu lato and Babesia sp.

Evidence of Bartonella sp. in questing adult and nymphal Ixodes ricinus ticks from France and co-infection with Borrelia burgdorferi sensu lato and Babesia sp.

Transmission ofBartonella henselaebyIxodes ricinus

Description of Lyme disease-like syndrome in Brazil: is it a new tick borne disease or Lyme disease variation?

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