<i>APOE</i>ε4 and Memory Among Patients With Heart Failure

Pressler, Susan J.; Harrison, Jordan; Titler, Marita G.; Koelling, Todd M.; Jung, Miyeon; Dorsey, Susan G.; Bakoyannis, Giorgos; Riley, Penny; Hoyland-Domenico, Lisa; Giordani, Bruno

doi:10.1177/0193945916670145

Cited by 8 publications

(11 citation statements)

References 49 publications

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“…In previous studies, ε4 frequencies among patients with HF who did not have diagnosis of AD or MCI were 24% and 33%. 19,20 However, in this study, only 14.7% of the HF participants with normal cognition had ε4 allele. Based on the results, it appears that irrespective of their APOE ε4 and ε2 carrier status, participants with HF in this sample were more likely to have AD than those without HF.…”

Section: Discussioncontrasting

confidence: 62%

“…33 Despite the advances in genomics research related to cognitive dysfunction, two studies have been reported in the HF literature in which the allelic frequencies were studied of APOE ε4 and ε2, and BDNF Val66Met. In a small sample of 29 patients with HF (76% White), 24% had at least one APOE ε4 allele, 19 21% had one APOE ε2 allele, Netherlands, 33% had at least one APOE ε4 allele and having ε4 allele was associated with poorer cognitive function as measured by a neuropsychological battery examining 5 cognitive domains of memory, executive function, visuospatial function, language, and mental speed/attention. 20 In summary, little is known about APOE ε2 and BDNF Met alleles in relation to cognitive dysfunction in HF.…”

Section: Introductionmentioning

confidence: 99%

“…However, few studies have been conducted that include genes known to increase or decrease risk of cognitive impairment in HF. 19,20 To date, genomics researchers have identified genetic biomarkers for cognitive dysfunction including the risk for developing Alzheimer's dementia (AD). 21,22 Apolipoprotein E (APOE) ε4 allele is associated with increased risk of developing AD [23][24][25][26] and MCI.…”

Section: Introductionmentioning

confidence: 99%

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Testing influences of APOE and BDNF genes and heart failure on cognitive function

et al. 2021

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Background: Apolipoprotein E (APOE) ε2, ε4 and brain-derived neurotrophic factor (BDNF) Val66Met alleles have been associated with cognition. Associations of these alleles with cognition in heart failure (HF) and influences of HF across the cognitive spectrum (i.e., cognitively normal to Alzheimer's dementia [AD]) remain unexplored.Objectives: To investigate influences of APOE ε2, ε4, BDNF Met and HF on cognition among participants across the cognitive spectrum.Methods: Genetic association study using national databases (N=7,166).Results: APOE ε2 frequencies were similar across the cognitive spectrum among participants with HF. APOE ε4 frequency was lower among participants with HF and AD than non-HF participants with AD. BDNF Met frequencies did not differ across the spectrum. HF was associated with worse attention and language. In the HF subsample, ε4 was associated with worse memory. Conclusion:Associations between APOE and cognition may differ in HF but need to be tested in a larger sample.

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Section: Discussioncontrasting

confidence: 62%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Testing influences of APOE and BDNF genes and heart failure on cognitive function

et al. 2021

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“…The Promega BDNF EMax Immunoassay System produces less than 3% cross‐reactivity with other neurotrophic factors and can detect BDNF at concentrations as low as 15.6 pg/ml. The protocol and procedures have been previously published (BDNF Emax ImmunoAssay System, 2009; Pressler et al, 2017).…”

Section: Methodsmentioning

confidence: 99%

Symptom cluster profiles following traumatic orthopedic injuries: A protocol

Breazeale

Dorsey

Kearney

et al. 2020

Research in Nursing & Health

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Traumatic injuries affect millions of Americans annually, resulting in $671 billion in healthcare costs and lost productivity. Postinjury symptoms, like pain, sleep disturbance, anxiety, depression, and stressor‐related disorders are highly prevalent following traumatic orthopedic injuries (TOI) and may contribute to negative long‐term outcomes. Symptoms rarely present in isolation, but in clusters of two or more symptoms that co‐occur to affect health in aggregate. Identifying symptom cluster profiles following TOI may identify those at highest risk for negative outcomes. Dysregulation of brain‐derived neurotrophic factor (BDNF) is a potential biological mechanism responsible for symptom cluster profile membership after TOI and may be targeted in future precision‐health applications. The purpose of this paper is to present the protocol of a cross‐sectional study designed to identify symptom cluster profiles and measure the extent to which the BDNF val66met mutation and serum concentration of BDNF are associated with membership in symptom cluster profiles. We plan to recruit 150 TOI survivors within the first 72 h of injury. The study aims are to (1) describe TOI survivors’ membership in symptom cluster profiles, indicated by pain, sleep disturbance, and symptoms of anxiety, depression, and stressor‐related disorders, immediately following a TOI; (2) examine associations between demographic and clinical factors and symptom cluster profile membership among TOI survivors; (3) test the hypothesis that low serum concentrations of BDNF are associated with membership among symptom cluster profiles following TOI; and (4) test the hypothesis that the presence of the val66met mutation on one or both alleles of the BDNF gene is associated with membership among symptom cluster profiles following TOI.

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“…Finally, Vogels and colleagues 71 reported that 33% of 62 HF patients in the Netherlands had at least one copy of the APOE-ε4 allele. In the preliminary MEMOIR-2 study, 7 (24.1%) of 29 HF patients had APOE-ε4 allele, 73 potentially increasing their risk for memory disorders and altering their responses to cognitive training interventions.…”

Section: Methodsmentioning

confidence: 99%