2011
DOI: 10.1096/fj.11-180935
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APOEε4is associated with higher vitamin D levels in targeted replacement mice and humans

Abstract: The allele ε4 of apolipoprotein E (APOE), which is a key regulator of lipid metabolism, represents a risk factor for cardiovascular diseases and Alzheimer's disease. Despite its adverse effects, the allele is common and shows a nonrandom global distribution that is thought to be the result of evolutionary adaptation. One hypothesis proposes that the APOE ε4 allele protects against vitamin D deficiency. Here we present, for the first time, experimental and epidemiological evidence that the APOE ε4 allele is ind… Show more

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Cited by 71 publications
(83 citation statements)
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“…As mentioned in the literature review, some studies have shown a connection between apoE genotypes and vitamin D metabolism [15,31]. This fact could have been included in the messages, especially since a low vitamin D concentration in the serum is a factor predisposing to CVD [15].…”
Section: Discussionmentioning
confidence: 99%
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“…As mentioned in the literature review, some studies have shown a connection between apoE genotypes and vitamin D metabolism [15,31]. This fact could have been included in the messages, especially since a low vitamin D concentration in the serum is a factor predisposing to CVD [15].…”
Section: Discussionmentioning
confidence: 99%
“…Carriers of the apoE ԑ4 allele may even have a 42% higher risk for CVD than carriers of the apoE 3/3 genotype [14]. It is also known that a low vitamin D serum level is a risk factor for CVD [15]. The reported relation between apoE genotype and serum vitamin D content may be due to the better absorption of dietary fats among apoE ε4 carriers [15].…”
Section: Introductionmentioning
confidence: 99%
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“…An alternative (n-3) PUFA is Table 4. Effects of the apoE isoform on parameters of vitamin D and Ca status evident in apoE4 compared with apoE3 targeted gene replacement mice (46) Parameter Renal absorption of Ca from primary urine (Trpv6, S100g)…”
Section: Plant and Marine N-3 Fatty Acidsmentioning
confidence: 99%
“…Another potential explanation for the results found in the present study is the fact that the presence of the ε4 allele leads to greater intestinal absorption and renal reuptake of vitamin D 39 . It has been suggested that higher concentrations of this vitamin may promote physical performance 40,41 , decreasing the risk of mobility limitation 42 .…”
Section: Discussionmentioning
confidence: 67%