<i>Anncaliia algerae</i>Microsporidial Myositis

Watts, Matthew; Chan, Renee C.F.; Cheong, Elaine; Brammah, Susan; Clezy, Kate; Tong, Chiwai; Marriott, Deborah; Webb, Cameron E.; Chacko, Bobby; Tobias, Vivienne; Outhred, Alexander C.; Field, Andrew; Prowse, Michael V.; Bertouch, J. V.; Stark, Damien; Reddel, Stephen W.

doi:10.3201/eid2002.131126

Cited by 29 publications

(40 citation statements)

References 35 publications

(73 reference statements)

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“…In resource‐limited settings, where the specific genus of microsporidia may not be identified, triple combination therapy should be given to cover all potential microsporidial species. A recent publication from Australia reported a similar observation in a patient who was given albendazole, sulfadiazine, and pyrimethamine and survived, whereas a patient who did not receive this regimen died . We observed that, in the absence of appropriate antimicrobial treatment, the disease progresses rapidly over a period of weeks to produce quadriparesis and esophageal involvement before death.…”

Section: Discussionsupporting

confidence: 74%

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Microsporidial polymyositis in human immunodeficiency virus−infected patients, a rare life‐threatening opportunistic infection: Clinical suspicion, diagnosis, and management in resource‐limited settings

Patel

Chickabasaviah

et al. 2015

Muscle and Nerve

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Section: Discussionsupporting

confidence: 74%

“…− This phenomenon may be due to the rarity and lack of awareness of this disease involving the muscles; therefore, the diagnosis may not be suspected clinically. A recent publication from Australia reported an antemortem diagnosis of microsporidial myositis in 2 rheumatoid arthritis patients …”

Section: Discussionmentioning

confidence: 99%

Microsporidial polymyositis in human immunodeficiency virus−infected patients, a rare life‐threatening opportunistic infection: Clinical suspicion, diagnosis, and management in resource‐limited settings

Patel

Chickabasaviah

et al. 2015

Muscle and Nerve

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“…; Watts et al. ; Weiss ). It was shown by experiments that a broad range of hosts including gammarids easily acquired A. algerae infection after per oral or per cutaneous experimental challenge with spores (Becnel et al.…”

Section: Discussionmentioning

confidence: 99%

Molecular and Morphological Characterization of Anncaliia azovica sp. n. (Microsporidia) Infecting Niphargogammarus intermedius (Crustacea, Amphipoda) from the Azov Sea

Tokarev

Sokolova

Vasilieva

et al. 2017

J Eukaryotic Microbiology

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Five out of one hundred adults of Niphargogammarus intermedius caught at the Azov sea shore were found to be infected with microsporidia. The infection was found in the subcuticular fat body and myocytes. Parasites developed in direct contact with host cells, displayed a disporoblastic sporogony and diplokaryotic arrangement of nuclei at all stages. Spores were oval, 4.6-5.8 × 2.6-3.0 μm. Exospore appendages, vesicular-tubular secretions, and the anisofilar polar filament indicated a similarity to Anncaliia species. Sporont surfaces displayed ridges of amorphous material. Meronts and sporonts formed protoplastic extensions, similar to A. vesicularum and A. meligheti. Mature spores possessed a bipartite polaroplast. The polar tube was arranged in one row of 13-18 coils including 0-3 distal coils of lesser diameter. Partial sequencing of SSU, ITS, and LSU regions of rRNA gene (GenBank accessions: KY288064-KY288065) confirmed this new species to be congeneric with A. algerae (#AF069063) and A. meligheti (#AY894423). The SSU gene of this novel microsporidium shared 99.4% sequence similarity to A. algerae and 98.9% to A. meligheti. Genes for HSP70 and RPB1 amplified with primers designed for A. algerae orthologs displayed 99.7% and 97.4% similarity, respectively, between A. algerae and the novel microsporidium. A new species, Anncaliia azovica, is described based on morphological and molecular characterization.

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“…In subsequent years, the incidence of Microsporidia has declined dramatically in response to better management of HIV infection with improvement in cellular immunity. However, awareness of the importance of microsporidian infections has again been raised through the recognition that transplant recipients and patients undergoing immunosuppressive therapy for illnesses such as rheumatoid arthritis may be vulnerable to infection (119)(120)(121)(122). There is also evidence that decline in CD8 levels has been linked to infection (123).…”

Section: Stains For the Microsporidiamentioning

confidence: 99%

Practical Guidance for Clinical Microbiology Laboratories: Laboratory Diagnosis of Parasites from the Gastrointestinal Tract

Garcia¹,

et al. 2018

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This Practical Guidance for Clinical Microbiology document on the laboratory diagnosis of parasites from the gastrointestinal tract provides practical information for the recovery and identification of relevant human parasites. The document is based on a comprehensive literature review and expert consensus on relevant diagnostic methods. However, it does not include didactic information on human parasite life cycles, organism morphology, clinical disease, pathogenesis, treatment, or epidemiology and prevention. As greater emphasis is placed on neglected tropical diseases, it becomes highly probable that patients with gastrointestinal parasitic infections will become more widely recognized in areas where parasites are endemic and not endemic. Generally, these methods are nonautomated and require extensive bench experience for accurate performance and interpretation.

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Anncaliia algeraeMicrosporidial Myositis

Abstract: Immunosuppression is a risk factor for serious infection in humans.

Cited by 29 publications

References 35 publications

Microsporidial polymyositis in human immunodeficiency virus−infected patients, a rare life‐threatening opportunistic infection: Clinical suspicion, diagnosis, and management in resource‐limited settings

Microsporidial polymyositis in human immunodeficiency virus−infected patients, a rare life‐threatening opportunistic infection: Clinical suspicion, diagnosis, and management in resource‐limited settings

Molecular and Morphological Characterization of Anncaliia azovica sp. n. (Microsporidia) Infecting Niphargogammarus intermedius (Crustacea, Amphipoda) from the Azov Sea

Practical Guidance for Clinical Microbiology Laboratories: Laboratory Diagnosis of Parasites from the Gastrointestinal Tract

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