<i>Amauroderma rugosum</i>(Blume &amp; T. Nees) Torrend: Nutritional Composition and Antioxidant and Potential Anti-Inflammatory Properties

Chan, Pui-Mun; Kanagasabapathy, Gowri; Tan, Yanli; Sabaratnam, Vikineswary; Kuppusamy, Umah Rani

doi:10.1155/2013/304713

Cited by 37 publications

(51 citation statements)

References 36 publications

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“…Consistent with our findings, previous chemical investigation of B. virgilioides has revealed the presence of phenolic compounds (Arriaga et al, 2000;Dos Santos et al, 2014). Nowadays, phenolic compounds are well known because of their anti-inflammatory properties (Chan et al, 2013;Lu et al, 2014).…”

Section: Discussionsupporting

confidence: 93%

Aqueous extract of Bowdichia virgilioides stem bark inhibition of allergic inflammation in mice

Silva¹,

Ferro²,

Filho³

et al. 2016

J. Med. Plants Res.

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Section: Discussionsupporting

confidence: 93%

Aqueous extract of Bowdichia virgilioides stem bark inhibition of allergic inflammation in mice

Silva¹,

Ferro²,

Filho³

et al. 2016

J. Med. Plants Res.

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“…Thus, it has been estimated that usually the content of carbohydrate, protein and fibre of mushrooms range from 51-88%, 19-35% and 4-20% of RDA respectively. 15 Consequently, L. sulphureus has also appeared as an excellent nutrient supply that influenced extensive studies in different laboratories. However, data varies considerably as a number of factors influence the nutritional value such as growing site, nature of substrate, pileus size, developmental stages and part of fungal samples analysed.…”

Section: Nutritional Valuementioning

confidence: 99%

Laetiporus sulphureus (Bull.: Fr.) Murr. as Food as Medicine

Khatua

Ghosh²,

Acharya

2017

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“…Mycelia of A . rugosum was maintained on PDA medium as described in the previous study [ 16 ]. Mushroom cultivation of A .…”

Section: Methodsmentioning

confidence: 99%

“…MTT assay was performed as previously described [ 16 ] to determine the cytotoxicity effect of A . rugosum extracts on RAW264.7 cells.…”

Section: Methodsmentioning

confidence: 99%

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Attenuation of Inflammatory Mediators (TNF-α and Nitric Oxide) and Up-Regulation of IL-10 by Wild and Domesticated Basidiocarps of Amauroderma rugosum (Blume & T. Nees) Torrend in LPS-Stimulated RAW264.7 Cells

et al. 2015

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Amauroderma rugosum, commonly known as “Jiǎzī” in China, is a wild mushroom traditionally used by the Chinese to reduce inflammation, to treat diuretic and upset stomach, and to prevent cancer. It is also used by the indigenous communities in Malaysia to prevent epileptic episodes and incessant crying by babies. The aim of this study was to compare the wild and domesticated basidiocarps of A. rugosum for antioxidant and in vitro anti-inflammatory effects in LPS-stimulated RAW264.7 cells. The wild basidiocarps of A. rugosum were collected from the Belum Forest, Perak, Malaysia and the domesticated basidiocarps of A. rugosum were cultivated in the mushroom house located in the University of Malaya, Kuala Lumpur, Malaysia. Both the wild and domesticated basidiocarps were subjected to ethanolic extraction and the extracts were tested for antioxidant and anti-inflammatory activities. In this study, the crude ethanolic extract of wild (WB) and domesticated (DB) basidiocarps of A. rugosum had comparable total phenolic content and DPPH scavenging activity. However, WB (EC50 = 222.90 μg/mL) displayed a better ABTS cation radical scavenging activity than DB (EC50 = 469.60 μg/mL). Both WB and DB were able to scavenge nitric oxide (NO) radical and suppress the NO production in LPS-stimulated RAW264.7 cells and this effect was mediated through the down-regulation of inducible nitric oxide synthase (iNOS) gene. In addition, both WB and DB caused down-regulation of the inflammatory gene TNF-α and the up-regulation of the anti-inflammatory gene IL-10. There was no inhibitory effect of WB and DB on nuclear translocation of NF-κB p65. In conclusion, the wild and domesticated basidiocarps of A. rugosum possessed antioxidant and in vitro anti-inflammatory properties. WB and DB inhibited downstream inflammatory mediators (TNF-α and NO) and induced anti-inflammatory cytokine IL-10 production. No inhibitory effects shown on upstream nuclear translocation of NF-κB p65. WB and DB exhibited antioxidant activity and attenuation of proinflammatory mediators and therefore, A. rugosum may serve as a potential therapeutic agent in the management of inflammation.

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Amauroderma rugosum(Blume & T. Nees) Torrend: Nutritional Composition and Antioxidant and Potential Anti-Inflammatory Properties

Cited by 37 publications

References 36 publications

Aqueous extract of Bowdichia virgilioides stem bark inhibition of allergic inflammation in mice

Aqueous extract of Bowdichia virgilioides stem bark inhibition of allergic inflammation in mice

Laetiporus sulphureus (Bull.: Fr.) Murr. as Food as Medicine

Attenuation of Inflammatory Mediators (TNF-α and Nitric Oxide) and Up-Regulation of IL-10 by Wild and Domesticated Basidiocarps of Amauroderma rugosum (Blume & T. Nees) Torrend in LPS-Stimulated RAW264.7 Cells

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