Aeollanthus pubescensBenth. from Benin: A Potential Source of Essential Oil with High Antiradical Efficiency

Abstract

The chemical composition of the essential oils obtained by hydrodistillation from leaves of three samples of Aeollanthus pubescens Benth. (Lamiaceae) growing wild in Benin were analyzed by GC and GC-MS. To date the biological functions of A. pubescens essential oils have not been demonstrated scientifically even if this plant is traditionally used by local population in alimentary and medicine. We investigated the chemical composition of A. pubescens essential oils and their antiradical and anti-inflammatory activities. Twenty four compounds were identified and quantified in the essential oils, the major compounds being thymol (63.6 %; 9.5 %; 63.4 %), carvacrol (3.1 %; 51.1 %; 2.1 %), thymyl acetate (9.8 %; 0.8 %; 10.2 %), carvacryl acetate (0.8 %; 6.1 %; 0.7 %), p-cymene (5.6 %; 9.0 %; 5.5 %) and γ-terpinene (6.4 % ; 11.2 %; 6.6 %). The antiradical activity of these oils was found to be high and a low anti-inflammatory activity was observed. Fractionation of a thymol rich sample allowed the identification of the bioactive fractions and their contribution to the efficiency of the whole extract. This study suggests that A. pubescens essential oils may be useful in the food industry where the antioxidants are used to retard the degradation of fatty substances, but also in cosmetics or in the field of herbal medicine, where the radical species are associated with the concept of antiaging.

Phytochemistry and antibacterial activity of plants extracts compared with two commercial antibiotics against <em>E coli</em> responsible for avian colibacillosis in Benin

“…The studied plant material is consisted of four plants, including Psidium guajava leaves harvested in Lokossa municipality and the whole Euphorbia hirta plant harvested in Abomey-Calavi identified respectively as AA 6718 /HNB and AA 6719 / HNB at the National Herbarium of Benin (HNB). The leaves of Clausena anisata harvested by Adjalian et al [11] and the organs (whole plant, flowers and leafy stem) of Aeollanthus pubescens harvested at Dassa (Benin) and previously studied by Alitonou et al [12] and identified by the National Herbarium of Benin (HNB) during other projects are parts of our plant material.…”

Antibacterial Activity of Essential Oil of &lt;i&gt;Aeollanthus pubescens&lt;/i&gt; on Multidrug Resistant Strains of &lt;i&gt;Salmonella&lt;/i&gt; and &lt;i&gt;Escherichia coli&lt;/i&gt; Isolated from Laying Hens Farming in Benin

“…In addition, the essential oil of Aeollanthus pubescens showed a bactericidal effect on the various strains investigated, which is in accordance with the results obtained by Sessou et al [7] It is important to emphasize that the work of these authors did not consider the investigation of Salmonella in their studies. The action of this essential oil of A. pubescens is due to its high concentration of thymol, α-terpinene, carvacrol and borneol [12] [26]. Indeed, these compounds are already recognized for their antibacterial activity, particularly thymol and carvacrol, which are the most bactericidal [27].…”

“…The essential oil of Aeollanthus pubescens used in this study in previously extracted by hydro distillation and analyzed chemically using GC and GC-MS by Alitonou et al [12].…”

Kazakh Ziziphora Species as Sources of Bioactive Substances

“…rigida [21] Z. clinopodioides subsp. rigida (12.5%) [21] Z. tenuior (53.97%) [179] Linalool ( Anti-inflammatory (in carrageenan-induced edema and inhibition of hyperalgesia induced by L-glutamate and prostaglandin E 2 in rats) [311]; anti-inflammatory (through inhibition of the expression of TNF-α and IL-6 in LPS-stimulated RAW 264.7 cells) [312]; anti-inflammatory (in cigarette smoke-induced ALI in mice through inhibiting NF-κB activation) [313] Cytotoxic (human amelanotic melanoma cell line C32, renal cell adenocarcinoma ACHN, hormone-dependent prostate carcinoma LNCaP) [314]; induction of apoptosis (variety of human leukaemia cells) [315][316][317] Hypocholesterolemic (through inhibition of HMG-CoA reductase and conversion of lanosterol to cholesterol) [318,319] Protective effect against t-BOOH induced mutagenesis [194] Review on some effects on cardiovascular system [221] Sedative and anxiolytic [320]; antidepressant [321]; GABA A receptor modulation [322] Analgesic activity reviewed [199] Review on metabolism and toxicity [200] Molecules 2016, 21, 826 20 of 53 [296]; antioxidant [273,[297][298][299] Review on some effects on cardiovascular system [221] Gastroprotective effects in the acute and chronic ulcer models in rats [300] Positive allosteric modulator of the GABAA receptors in primary cultures of mouse cortical neurons [301] Anti-hyperglycemic and anti-hyperlipidemic activity in high fat-induced type 2 diabetic C57BL/6J mice [302] and protective effect in nephropathy [303] Analgesic activity reviewed [199] Review on metabolism and toxicity [200]; general review on thyme and 62 [304] cis-Sabinene hydrate …”

“…clinopodioides (2.7%) [185] n.f. Molecules 2016, 21, 826 20 of 53 [296]; antioxidant [273,[297][298][299] Review on some effects on cardiovascular system [221] Gastroprotective effects in the acute and chronic ulcer models in rats [300] Positive allosteric modulator of the GABAA receptors in primary cultures of mouse cortical neurons [301] Anti-hyperglycemic and anti-hyperlipidemic activity in high fat-induced type 2 diabetic C57BL/6J mice [302] and protective effect in nephropathy [303] Analgesic activity reviewed [199] Review on metabolism and toxicity [200]; general review on thyme and 62 [304] cis-Sabinene hydrate (63) Z. clinopodioides (0.3%-2.2%) [184] Antiviral (HSV-1) [282] OH H Z. clinopodioides subsp. bungeana [201] trans-Sabinene hydrate (64) Z. clinopodioides subsp.…”