Aedes aegypti Larvicidal Sesquiterpene Alkaloids from Maytenus oblongata

Abstract

Four new sesquiterpene alkaloids (1-4) with a β-dihydroagrofuran skeleton and a new triterpenoid (5) were isolated from an ethyl acetate extract of Maytenus oblongata stems. Their structures were elucidated using 1D and 2D NMR spectroscopy as well as MS and ECD experiments. The M. oblongata stem EtOAc extract and the pure compounds isolated were tested for larvicidal activity against Aedes aegypti under laboratory conditions, and compounds 2 and 3 were found to be active.

Towards the optimization of botanical insecticides research: Aedes aegypti larvicidal natural products in French Guiana

“…Insect collection and rearing, cup assay and data analysis were performed as previously described (Touré et al 2017). Two Aedes aegypti (Diptera: Culicidae) strains were used for testing the extracts and compounds.…”

“…The thoroughgoing bioguided fractionation as well as isolation and identification of M. oblongata extract components were described in Touré et al (2017).…”

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“…Different extracts were obtained from Mirabilis jalapa L. (Nyctaginaceae) leaves and investigated for their L3 larvicidal activity: methanol (LC 50 [101,102]. The latter also demonstrated ovicidal activity at 200 ppm (100% non-hatchability) [102].…”

“…Other sesquiterpene alkaloids with strong larvicidal activity (L3 and L4 instar) were 1-O-benzoyl-1-deacetyl-4-deoxyalatamine (33) (LC 50 9.4 µM) and 1,2-O-dibenzoyl-1,2-deacetyl-4-deoxyalatamine (34) (LC 50 2.3 µM). These sesquiterpenes with a β-dihydroagrofuran skeleton were isolated from M. oblongata stems [101].…”

“…Larvicidal activity was also reported for Maytenus oblongata Reissek (Celasteraceae) bark ethyl acetate extract (LC 50 74.4 µg/mL) and Millettia pachycarpa Benth. (Fabaceae) root ethanol extract (LC 50 98.47 µg/mL) [ 101 , 102 ]. The latter also demonstrated ovicidal activity at 200 ppm (100% non-hatchability) [ 102 ].…”