<i>Action of Bioflavonoids on Inflammation</i>

Salgado, E; Green, D. M.

doi:10.1152/jappl.1956.8.6.647

Cited by 9 publications

(9 citation statements)

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“…Decrease in GRP 58 expression would affect MHC class I antigen presentation, reducing with it CD8+ Tlymphocyte activation. The anti-inflammatory properties of citrus flavonoids were already demonstrated 50 years ago [18] , and recent evidence suggests that inhibition of cytokine-induced gene expression is a path by which flavonoids can exert anti-inflammatory effects. In fact, another flavonoid (apigenin) has been shown to re-duce cytokine production (IL-6, IL-8) both in vivo and in vitro [41] .…”

Section: Discussionmentioning

confidence: 97%

“…Perhaps the early work of Salgado and Green [18] in 1956 provided one of the first systematic studies demonstrating that citrus flavonoids could in fact significantly inhibit inflammation in vivo. More recently, studies on diabetic animal models attributed hypoglycemic effects to naringin [19] .…”

Section: Plant Polyphenol Intake Alters Gene Expression In Canine Leumentioning

confidence: 99%

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Plant Polyphenol Intake Alters Gene Expression in Canine Leukocytes

Salas¹,

Subirada²,

Pérez‐Enciso³

et al. 2009

Lifestyle Genomics

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Background/Aims: Polyphenol compounds may explain most of the health-related beneficial effects of plants and vegetables, mainly through their antioxidant properties. The aim of the study was to assess the main changes on leukocyte gene expression of dogs caused by intake of three natural polyphenol-rich extracts and to compare them with caloric restriction. Methods: 20 female dogs were divided into 5 groups: control fed ad libitum (C), caloric-restricted to 30% less than control (CR), and 3 groups fed ad libitum supplemented with citrus extract (CE), green tea extract (GTE) or grape seed extract (GSE). Leukocytes gene expression was analyzed in a specially designed microarray. Results: CE treatment mainly downregulated genes related to inflammative (IL-8, VLA-4) and cytotoxic response (GRP 58) as well as proliferation of leukocytes. GTE induced gene expression related to leukocyte proliferation and signaling (GNAQ, PKC-B). GSE upregulated some of the genes increased by CE treatment. CR downregulated genes related with energy metabolism (ATP5A1, COX7C) and inflammatory markers (VLA-4). Conclusion: A chronic ingestion of citric, grape seed and green tea polyphenols is able to modulate canine leukocyte functions through changes in gene expression. CE ingestion reduces expression of some genes also diminished by a 30% caloric restriction.

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Section: Discussionmentioning

confidence: 97%

Section: Plant Polyphenol Intake Alters Gene Expression In Canine Leumentioning

confidence: 99%

Plant Polyphenol Intake Alters Gene Expression in Canine Leukocytes

Salas¹,

Subirada²,

Pérez‐Enciso³

et al. 2009

Lifestyle Genomics

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“…The early work by Salgado and Green [24] provided perhaps one of the first systematic studies demonstrating that citrus flavonoids could in fact significantly inhibit inflammation in vivo. Several citrus flavanone glycosides, hesperidin and naringin, and their aglycones, administered at a dose of 45 mg Kg -1 day -1 , were active against the inflammatory response of the rat granuloma pouch model.…”

Section: Antiinflammatory Properties Of Citrus Flavonoidsmentioning

confidence: 99%

Biological Properties of Citrus Flavonoids Pertaining to Cancer and Inflammation

Manthey¹,

Guthrie²,

Grohmann³

2001

CMC

491

312

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Citrus flavonoids encompass a diverse set of structures, including numerous flavanone and flavone O- and C-glycosides and methoxylated flavones. Each of these groups of compounds exhibits a number of in vitro and in vivo anti-inflammatory and anticancer actions. These biological properties are consistent with their effects on the microvascular endothelial tissue. Evidence suggests that the biological actions of the citrus flavonoids are possibly linked to their interactions with key regulatory enzymes involved in cell activation and receptor binding. The citrus flavonoids show little effect on normal, healthy cells, and thus typically exhibit remarkably low toxicity in animals. The citrus flavonoids extend their influence in vivo through their induction of hepatic phase I and II enzymes, and through the biological actions of their metabolites. Evidence clearly indicates to the potential health promoting properties of these dietary compounds.

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“…According to SALGADO and GREEN (1955), the volume of inflammatory exudate in the granuloma pouch can be significantly decreased by a parenteral flavonoid treatment. As a result of the oral administration of large doses of trihydroxyethylrutoside, RADouco-THOMAS et ai.…”

Section: Discussionmentioning

confidence: 99%

“…Using the SELYE granuloma pouch method (1953), SALGADO and GREEN (1955) investigated the anti-inflammatory actions of calcium flavone glycoside, lemon bioflavonoid complex, hesperidin complex, hesperidin, hesperidin methyl chalcone, hesperetin, naringin, and naringenin. The granuloma pouch was induced in rats by the injection of croton oil; directly afterwards, and daily for 10-12 days, the animals received a bioflavonoid treatment (once daily in the case of s.c. administration, twice daily in the case of oral application).…”

Section: Effect On the Development Of The Granuloma Pouchmentioning

confidence: 99%

Anti-Inflammatory Substances of Plant Origin

Gábor¹

1979

Handbook of Experimental Pharmacology

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Action of Bioflavonoids on Inflammation

Cited by 9 publications

References 0 publications

Plant Polyphenol Intake Alters Gene Expression in Canine Leukocytes

Plant Polyphenol Intake Alters Gene Expression in Canine Leukocytes

Biological Properties of Citrus Flavonoids Pertaining to Cancer and Inflammation

Anti-Inflammatory Substances of Plant Origin

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