Anti-Inflammatory Substances of Plant Origin

Gábor, M

doi:10.1007/978-3-642-66891-3_21

Cited by 44 publications

(19 citation statements)

References 89 publications

(69 reference statements)

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“…Flavonoids form a group of naturally occurring phenoylbenzo-γ-pyrones present in plants commonly found in human and animal diet (Gabor 1979). Members of this group have been found to have significant anti-inflammatory properties in several rodent paradigms (see for reviews Gabor 1979;Havsteen 1983;Middleton and Kandaswami 1992).…”

Section: Discussionmentioning

confidence: 99%

Endotoxin-induced reduction of social investigation by mice: interaction with amphetamine and anti-inflammatory drugs

Fishkin¹,

Winslow²

1997

Psychopharmacology

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Previous studies indicate that some aspects of endotoxin-induced sickness behavior in rats may be mediated by interleukin-1 stimulated events and can be attenuated by corticosteroids, cyclooxygenase inhibitors and the interleukin-1-receptor antagonist. In the current studies, we replicate and extend these findings in adult male mice. A relatively low dose of lipopolysaccharide (LPS; 15 micrograms/kg, IP) was used to reliably induce a 50-60% reduction in the social investigation of a juvenile conspecific at 2-3 h after injection. Amphetamine (2.0-4.0 mg/kg, IP, 30 min pre-LPS) exacerbated LPS-induced decreases in investigation. Administration of methylprednisolone (10-30 mg/kg, IP), indomethacin (3-30 mg/kg, IP), and ibuprofen (1-100 mg/kg, IP) 1 h before LPS significantly reduced LPS-induced sickness behavior at several doses. Dexamethasone (0.1-10 mg/kg, IP) partially antagonized sickness. Representative flavonoids rohitukine (0.01-100.0 mg/kg, IP) and chrysin (0.01-10 mg/kg, IP) also antagonized LPS-induced deficits in social investigation. These studies replicate and extend previous studies in rat to demonstrate systematic effects of low doses of LPS, antagonism by anti-inflammatory drugs and enhancement of LPS effects by amphetamine. The latter findings are consistent with a modulatory role for adrenergic activation on interleukin-1 release stimulated by endotoxicity.

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Section: Discussionmentioning

confidence: 99%

Endotoxin-induced reduction of social investigation by mice: interaction with amphetamine and anti-inflammatory drugs

Fishkin¹,

Winslow²

1997

Psychopharmacology

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“…Flavonoids inhibit many enzymes, including cyclooxygenase, lipoxygenase (2, 52), phospholipase A 2 (2), and STAT-1 activation (68). Flavonoids also act as antioxidants (11,14) and have anti-inflammatory actions (26). The specific actions of flavones may have been to increase the binding affinity of substrate (39) or to improve the electron transfer efficiency between NADPH/ cytochrome P-450 reductase and the P-450 enzyme (37,45).…”

Section: Discussionmentioning

confidence: 99%

Cardioprotective mechanisms ofPrunus cerasus(sour cherry) seed extract against ischemia-reperfusion-induced damage in isolated rat hearts

Bak¹,

Lekli²,

Juhász³

et al. 2006

American Journal of Physiology-Heart and Circulatory Physiology

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Cardioprotective mechanisms of Prunus cerasus (sour cherry) seed extract against ischemia-reperfusion-induced damage in isolated rat hearts. Am J Physiol Heart Circ Physiol 291: H1329 -H1336, 2006. First published April 14, 2006 doi:10.1152/ajpheart.01243.2005The effects of kernel extract obtained from sour cherry (Prunus cerasus) seed on the postischemic cardiac recovery were studied in isolated working rat hearts. Rats were treated with various daily doses of the extract for 14 days, and hearts were then isolated and subjected to 30 min of global ischemia followed by 120 min of reperfusion. The incidence of ventricular fibrillation (VF) and tachycardia (VT) fell from their control values of 92% and 100% to 50% (not significant) and 58% (not significant), 17% (P Ͻ 0.05), and 25% (P Ͻ 0.05) with the doses of 10 mg/kg and 30 mg/kg of the extract, respectively. Lower concentrations of the extract (1 and 5 mg/kg) failed to significantly reduce the incidence of VF and VT during reperfusion. Sour cherry seed kernel extract (10 and 30 mg/kg) significantly improved the postischemic recovery of cardiac function (coronary flow, aortic flow, and left ventricular developed pressure) during reperfusion. We have also demonstrated that the extract-induced protection in cardiac function significantly reflected in a reduction of infarct size. Immunohistochemistry indicates that a reduction in caspase-3 activity and apoptotic cells by the extract, beside other potential action mechanisms of proanthocyanidin, trans-resveratrol, and flavonoid components of the extract, could be responsible for the cardioprotection in ischemic-reperfused myocardium.

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“…, 1984;Gryglewski et af. , 1985), inflammatory responses (Gabor, 1979;Alcaraz and Jimenez, 1988) and enzymes involved in arachidonate metabolism, i.e., cyclooxygenase and lipoxygenase enzymes . Quercetin, the most active flavonoid studied by Fanning and co-workers (1983), inhibits either contraction of guinea-pig ileum muscle stimulated by agonists or anaphylaxis.…”

Section: Introductionmentioning

confidence: 98%

Reduction of agonist‐induced contractions of guinea‐pig isolated ileum by flavonoids

Capasso

Pinto

Mascolo

et al. 1991

Phytotherapy Research

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The effect of 13 flavonoids on the contraction of guinea-pig isolated ileum induced by prostaglandin E2 (PGE2) and leukotriene D4 (LTD4) have been investigated. Apigenin, quercetin and kaempferol at a concentration of 10-mu-M significantly (p < 0.001) reduced the contraction to either agonist. Crysin and flavone antagonized only PGE2 (p < 0.01). The other flavonoids were inactive. The blocking effect of apigenin, quercetin and kaempferol against PGE2 was also concentration- and time-dependent, and was augmented by the calcium channel blocker verapamil or by lowering the extracellular calcium to 25%, consistent with a calcium-mediated mechanism of protection which these flavonoids, at the same concentration, also showed against barium chloride (BaCl2)- or acetylcholine (ACh)-induced contraction (p < 0.05-0.001)

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Anti-Inflammatory Substances of Plant Origin

Cited by 44 publications

References 89 publications

Endotoxin-induced reduction of social investigation by mice: interaction with amphetamine and anti-inflammatory drugs

Endotoxin-induced reduction of social investigation by mice: interaction with amphetamine and anti-inflammatory drugs

Cardioprotective mechanisms ofPrunus cerasus(sour cherry) seed extract against ischemia-reperfusion-induced damage in isolated rat hearts

Reduction of agonist‐induced contractions of guinea‐pig isolated ileum by flavonoids

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