<i>Abiotrophia</i>
            Species as a Cause of Endophthalmitis Following Cataract Extraction

Namdari, Hassan; Kintner, Kathleen; Jackson, Barbara A.; Namdari, Surena; Hughes, Joan L.; Peairs, Randall R.; Savage, Donald J.

doi:10.1128/jcm.37.11.3789-3789.1999

Cited by 11 publications

(16 citation statements)

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“…Furthermore, the case represents the first reported ocular A. defectiva infection in Germany (Table 1). So far, only one intraocular A. defectiva infection has been described in the English literature [10]. Recently, two cases have been reported in a Spanish journal, which possibly delay the knowledge about these infections (Table 1) [11,12].…”

Section: Discussionmentioning

confidence: 99%

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Abiotrophia defectiva endophthalmitis with retinal involvement and infiltrative keratitis: case report and review of the literature

Horstkotte

Dobinsky

Rohde

et al. 2010

Eur J Clin Microbiol Infect Dis

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We report the exceptional case of a severe intraocular Abiotrophia defectiva infection which developed after cataract surgery. Retinal involvement as a complication of A. defectiva endophthalmitis or the combination of acute-onset endophthalmitis with infiltrative keratitis caused by this pathogen has not been described. Moreover, our report represents the first documented ocular A. defectiva infection in Germany. A. defectiva was identified using biotyping and 16S ribosomal RNA gene sequence analysis. Despite vigorous antimicrobial therapy and repeated ocular surgery, visual outcome was poor.

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Section: Discussionmentioning

confidence: 99%

“…The related species Granulicatella adiacens has been isolated in a single case of AOPE [10] and corneal ulcer [3], respectively. Older reports mentioned NVS in one case of endophthalmitis associated with filtering bleb surgery [15] and four cases of infectious crystalline keratopathy [16].…”

Section: Discussionmentioning

confidence: 99%

Abiotrophia defectiva endophthalmitis with retinal involvement and infiltrative keratitis: case report and review of the literature

Horstkotte

Dobinsky

Rohde

et al. 2010

Eur J Clin Microbiol Infect Dis

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“…Abiotrophia defectiva , formerly designated as a nutritionally variant streptococcus, is part of the normal oral flora and a possible pathogen for culture‐negative endocarditis (Christensen et al 1999). It has also been isolated from keratitis and endophthalmitis patients (Namdari et al 1999; Keay et al 2000). In our third patient, an unambiguous identification of the PCR product was not possible.…”

Section: Discussionmentioning

confidence: 99%

16S rDNA PCR analysis of infectious keratitis: a case series

Rudolph

Welinder‐Olsson

Lind-Brandberg

et al. 2004

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: To discuss the value of polymerase chain reaction (PCR) in the management of bacterial infectious keratitis. Methods: Corneal scrapings of four patients with severe infectious keratitis were analysed by culture and PCR of 16S ribosomal DNA (rDNA), followed by direct sequencing of the resulting amplicon. The medical history of the patients included laser-assisted in-situ keratomileusis (LASIK), penetrating keratoplasty (PKP) and trauma. Results: Using PCR we were able to identify a possible pathogen in all four cases, while bacterial cultures were either negative or did not correspond to the clinical picture. The identified bacteria were a Pseudomonas species, Abiotrophia defectiva, Stenotrophomonas maltophilia and Porphyromonas gingivalis. Conclusions: Analysis of corneal scrapings by 16S rDNA PCR should be considered as a supplement to standard microbiological procedures. However, the results of this relatively new method have to be interpreted carefully.

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“…In den 1960er-Jahren ging man davon aus, dass NVS ("nutritionally variant streptococci") eine mutierte Form von Streptococcus-viridans-Stämmen sind [8]. Heute teilt man NVS in Abiotrophia defectiva und Granulicatella adiacens, Granulicatella balaenopterae und Granulicatella elegans ein [8,9]. NVS finden sich in der Mundhöhle sowie im oberen Respirationstrakt, im Urogenital-und Gastrointestinaltrakt [8].…”

Section: Introductionunclassified

“…Okuläre Infektionen mit Abiotrophia defectiva sind äußerst selten. In der Literatur wird von 2 Fällen in England, 1 Fall in Deutschland und 2 Fällen in Spanien berichtet, in denen Abiotrophia defectiva als Keim identifiziert wurde [8,9]. In den Fällen aus Deutschland und England traten die Symptome 3 bis 6 Tage nach erfolgter Kataraktchirurgie auf [8,9].…”

Section: Introductionunclassified