Hysterectomy, non-malignant gynecological diseases, and the risk of incident hypertension: The E3N prospective cohort

Madika, Anne‐Laure; MacDonald, Conor James; Gélot, A.; Hitier, S.; Mounier‐Véhier, Claire; Béraud, Guillaume; Kvaskoff, Marina; Boutron‐Ruault, Marie‐Christine; Bonnet, Fabrice

doi:10.1016/j.maturitas.2021.06.001

Cited by 9 publications

(3 citation statements)

References 43 publications

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“…Another cohort study conducted in Minnesota reported that hysterectomy with ovarian conservation was associated with an increased long-term risk of cardiovascular and metabolic conditions, including hypertension, particularly in women who underwent hysterectomy at less than 35 years of age 15. Similar results were found in a cross-sectional study on Indian women aged 15–49,16 and a study conducted on the French E3N cohort 17. However, the underlying mechanism of the association is still not well established 11…”

Section: Introductionsupporting

confidence: 56%

“…Previous research on the relationship between hysterectomy and hypertension produced inconsistent results; some studies found a positive association,14 16 17 23 while others found no relationship 6 24. All of the above-cited studies were mere epidemiological investigations; no study has looked at the underlying biological mechanism to explain the potential association between hysterectomy and hypertension.…”

Section: Discussionmentioning

confidence: 99%

“… 15 Similar results were found in a cross-sectional study on Indian women aged 15–49, 16 and a study conducted on the French E3N cohort. 17 However, the underlying mechanism of the association is still not well established. 11 …”

Section: Introductionmentioning

confidence: 99%

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Association between hysterectomy and hypertension among Indian middle-aged and older women: a cross-sectional study

Mustafa

2023

BMJ Open

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ObjectiveTo examine the association between hysterectomy and hypertension among middle-aged and older women in India, as well as to determine if the association differs across different age groups.DesignA cross-sectional exploratory study.Setting and participantsNationally representative population-based data of the Longitudinal Ageing Study in India (2017–2018) were used in this study. The sample included 32 460 women aged 45 years and above.Outcome measuresSelf-reported hypertension was the outcome variable. The variable was a binary variable, with 1 representing hypertensive and 0 representing not hypertensive.MethodsEntropy balance method, along with logistic regression analysis, was used to meet the objectives.Results31.3% of the women with hysterectomy and 42.5% of the women without hysterectomy were hypertensive. A perfect covariate balance was achieved between the treatment and control groups using the entropy balance method. Women with hysterectomy had 36% (OR 1.36; 95% CI 1.26 to 1.48) higher odds of hypertension than women without hysterectomy. The OR was 1.23 (95% CI 1.03 to 1.47) for the age group 45–49, whereas, for the age group 80+, it was 1.87 (95% CI 1.18 to 2.97), showing that the magnitude of the association between hysterectomy and hypertension varied with age.ConclusionThe findings of this study suggest that hysterectomy and hypertension have a significant association in middle-aged as well as older women in India.

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