Hypoxic Regulation of Blood Flow in Humans

Minson, Christopher T.

doi:10.1007/978-1-4419-8997-0_18

Cited by 31 publications

(12 citation statements)

References 40 publications

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“…These heterogeneous results probably arise from different techniques used. As mentioned earlier, plethysmography measures the combined blood flow of skin and muscles (Yvonne-Tee et al, 2006), while LD fluxmetry allows us to measure skin blood flow changes without the measurement of concomitant changes in underlying muscles (Minson, 2003).…”

Section: Discussionmentioning

confidence: 99%

“…With the use of an alternative non-invasive method of peripheral blood flow measurements [laser-Doppler (LD) fluxmetry] Cankar and Štrucl succeeded to confirm the role of K ATP channels in resting conditions, postocclusive hyperemia and microvascular local cold response (Cankar & Štrucl, 2008). The LD fluxmetry technique allows us to measure the microvascular perfusion in a distinct part of human skin without measuring concomitant changes in underlying muscle (Minson, 2003).…”

Section: Introductionmentioning

confidence: 99%

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The effect of glibenclamide on acetylcholine and sodium nitroprusside induced vasodilatation in human cutaneous microcirculation

Hojs

Štrucl

Cankar

2008

Clin Physio Funct Imaging

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The effect of glibenclamide on acetylcholine and sodium nitroprusside induced vasodilatation in human cutaneous microcirculation

Hojs

Štrucl

Cankar

2008

Clin Physio Funct Imaging

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“…(24,25) These are either a-adrenergic vasoconstrictor fibers or dilatory sudomotor fibers, as the control of cutaneous blood flow serves for crucial thermoregulation purposes. (26) Thus, both the reported finding that exposure of skin to hypoxia in vivo does not increase EPO expression and the blood flow redistribution argument invoked to explain this (9) are difficult to reconcile with widely accepted concepts. The same is true for the authors' idea that the ambient O 2 pressure could have a significant local influence on the O 2 pressure in dermal blood vessels (which appears to run contrary to the physical laws of gas diffusion).…”

Section: Hypothetical Role Of Mammalian Skin In Renal Epo Productionmentioning

confidence: 99%

Erythropoietin and the skin: a role for epidermal oxygen sensing?

Paus

Bodó

Kromminga³

et al. 2009

BioEssays

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Erythropoietin (EPO), long appreciated as the chief endocrine regulator of red blood cell formation, is now recognized to exert many additional functions outside the bone marrow. Thus, the quest is on to define the full range of EPO functions in the physiology and pathology of non-hematopoietic tissues. Two recent studies in man and mice have highlighted the importance of the mammalian skin as one peripheral tissue with a previously unsuspected role in EPO biology; both, as a target and as a source of EPO. In addition, the skin has been proposed to function as an oxygen sensor. The present hypothesis essay critically reviews the currently available evidence for this and provides a unifying theoretical scenario for intracutaneous EPO functions and for a potential role of the skin in the control of EPO production. Mainly, we propose that the skin itself directly contributes to the up-regulation of EPO plasma levels in response to hypoxia.

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“…The skin has an extensive vasculature, which is known to be responsive to shifts in oxygen availability (Durand, Verpillat, Pradel, & Martineaud, 1969;Minson et al, 2003). It has been implicated in the acute responsiveness to hypoxia and suggested that in humans it might play a role in the long-term adaptation to hypobaric hypoxia through local modulation of blood flow (Pucci et al, 2012).…”

Section: Is the Skin An Oxygen Sensor In Humans?mentioning

confidence: 99%

Sustained vasomotor control of skin microcirculation in Sherpas versus altitude‐naive lowlanders: Experimental evidence from Xtreme Everest 2

Davies

Gilbert‐Kawai

Wythe

et al. 2018

Experimental Physiology

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Enhanced oxygen delivery, consequent to an increased microvascular perfusion, has been postulated to play a key role in the physiological adaptation of Tibetan highlanders to the hypobaric hypoxia encountered at high altitude. We tested the hypothesis that Sherpas, when exposed to graded hypobaric hypoxia, demonstrate enhanced vasomotor and neurovascular control to maintain microcirculatory flux, and thus tissue oxygenation, when compared with altitude-naive lowlanders. Eighty-three lowlanders [39 men and 44 women, 38.8 (13.1) years old; mean (SD)] and 61 Sherpas [28 men and 33 women, 27.9 (6.9) years old] were studied on ascent to Everest Base Camp over 11 days. Skin blood flux and tissue oxygen saturation were measured simultaneously using combined laser Doppler fluximetry and white light spectroscopy at baseline, 3500 and 5300 m. In both cohorts, ascent resulted in a decline in the sympathetically mediated microvascular constrictor response (P < 0.001), which was more marked in lowlanders than in Sherpas (P < 0.001). The microvascular dilator response evaluated by postocclusive reactive hyperaemia was significantly greater in Sherpas than in lowlanders at all sites (P < 0.002). Spectral analysis of the blood flux signals revealed enhanced myogenic (vasomotion) activity in Sherpas, which was unaffected by ascent to 5300 m. Although skin tissue oxygenation was lower in Sherpas than in lowlanders, the oxygen unloading rate was faster, and deoxyhaemoglobin levels higher, at all altitudes. Together, these data suggest that Sherpas, when exposed to hypobaric hypoxia, demonstrated superior preservation of peripheral microcirculatory perfusion compared with altitude-naive lowlanders. The physiological differences in local microvasculature vasomotor and neurovascular control may play a key role in Sherpa adaptation to high-altitude hypobaric hypoxia by sustaining local perfusion and tissue oxygenation.

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Hypoxic Regulation of Blood Flow in Humans

Cited by 31 publications

References 40 publications

The effect of glibenclamide on acetylcholine and sodium nitroprusside induced vasodilatation in human cutaneous microcirculation

The effect of glibenclamide on acetylcholine and sodium nitroprusside induced vasodilatation in human cutaneous microcirculation

Erythropoietin and the skin: a role for epidermal oxygen sensing?

Sustained vasomotor control of skin microcirculation in Sherpas versus altitude‐naive lowlanders: Experimental evidence from Xtreme Everest 2

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