Hypoxic ADSC-derived exosomes enhance wound healing in diabetic mice via delivery of circ-Snhg11 and induction of M2-like macrophage polarization

Shi, Rongfeng; Jin, Yinpeng; Zhao, Song; Yuan, Haiyan; Shi, Jiahai; Zhao, Hui

doi:10.1016/j.biopha.2022.113463

Cited by 61 publications

(59 citation statements)

References 39 publications

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“…In fact, hypoxic environment has positive effects on survival and genetic stability of MSCs. Shi Rongfeng et al found that ADSCs-exo preconditioned by hypoxia could reduce endothelial cell damage in high glucose environment, increase the endothelial progenitor cell differentiation, and ultimately promote diabetic wound healing (45).…”

Section: Exosomes Derived From Hucmscsmentioning

confidence: 99%

The role of mesenchymal stem cell-derived EVs in diabetic wound healing

Jiang

et al. 2023

Front. Immunol.

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Diabetic foot is one of the most common complications of diabetes, requiring repeated surgical interventions and leading to amputation. In the absence of effective drugs, new treatments need to be explored. Previous studies have found that stem cell transplantation can promote the healing of chronic diabetic wounds. However, safety issues have limited the clinical application of this technique. Recently, the performance of mesenchymal stem cells after transplantation has been increasingly attributed to their production of exocrine functional derivatives such as extracellular vesicles (EVs), cytokines, and cell-conditioned media. EVs contain a variety of cellular molecules, including RNA, DNA and proteins, which facilitate the exchange of information between cells. EVs have several advantages over parental stem cells, including a high safety profile, no immune response, fewer ethical concerns, and a reduced likelihood of embolism formation and carcinogenesis. In this paper, we summarize the current knowledge of mesenchymal stem cell-derived EVs in accelerating diabetic wound healing, as well as their potential clinic applications.

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Section: Exosomes Derived From Hucmscsmentioning

confidence: 99%

The role of mesenchymal stem cell-derived EVs in diabetic wound healing

Jiang

et al. 2023

Front. Immunol.

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“…Circ-Snhg11 from hypoxia-pretreated ADSC exosome promoted diabetic wound healing by increasing vascular differentiation function of EPCs by activation of the miR-144–3p/HIF-1α/VEGF signaling pathway. The result also found that circ-Snhg11 can also promote M2-like macrophage polarization under HG conditions by the regulation of miR-144–3p/HIF-1α/STAT3 signaling pathway ( 64 ). A research by Wang at al.…”

Section: Exosomal Circrna For Diabetic Wound Healingmentioning

confidence: 97%

Exosomal ncRNAs: The pivotal players in diabetic wound healing

et al. 2022

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Diabetes is the most prevalent metabolic disease in the world today. In addition to elevated blood glucose, it also causes serious complications, which has a significant effect on the quality of life of patients. Diabetic trauma is one of complications as a result of the interaction of diabetic neuropathy, peripheral vascular disease, infection, trauma, and other factors. Diabetic trauma usually leads to poor healing of the trauma and even to severe foot ulcers, wound gangrene, and even amputation, causing serious psychological, physical, and financial burdens to diabetic patients. Non-coding RNAs (ncRNAs) carried by exosomes have been demonstrated to be relevant to the development and treatment of diabetes and its complications. Exosomes act as vehicle, which contain nucleic acids such as mRNA and microRNA (miRNA), and play a role in the intercellular communication and the exchange of substances between cells. Because exosomes are derived from cells, there are several advantages over synthetic nanoparticle including good biocompatibility and low immunogenicity. Exosomal ncRNAs could serve as markers for the clinical diagnosis of diabetes and could also be employed to accelerate diabetic wound healing via the regulation of the immune response and modulation of cell function. ncRNAs in exosomes can be employed to promote diabetic wound healing by regulating inflammation and accelerating re-vascularization, re-epithelialization, and extracellular matrix remodeling. Herein, exosomes in terms of ncRNA (miRNA, lncRNA, and circRNA) to accelerate diabetic wounds healing were summarized, and we discussed the challenge of the loading strategy of ncRNA into exosomes.

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“…hsa_circ_0005567 induces M2 polarization via the miR-492/SOCS2 axis [ 84 ], and circRNA HIPK3 induces inflammatory cytokines in macrophages by sponging miR-192 and miR-561 [ 85 ]. In wound healing, circRNA nhg11 promotes M2 macrophage polarization via the miR-144-3p/hypoxia-inducible factor (HIF)-1α axis [ 86 ].…”

Section: Reviewmentioning

confidence: 99%

Epigenetic regulation of macrophage polarization in wound healing

et al. 2023

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The immune microenvironment plays a critical role in regulating skin wound healing. Macrophages, the main component of infiltrating inflammatory cells, play a pivotal role in shaping the immune microenvironment in the process of skin wound healing. Macrophages comprise the classic proinflammatory M1 subtype and anti-inflammatory M2 population. In the early inflammatory phase of skin wound closure, M1-like macrophages initiate and amplify the local inflammatory response to disinfect the injured tissue. In the late tissue-repairing phase, M2 macrophages are predominant in wound tissue and limit local inflammation to promote tissue repair. The biological function of macrophages is tightly linked with epigenomic organization. Transcription factors are essential for macrophage polarization. Epigenetic modification of transcription factors determines the heterogeneity of macrophages. In contrast, transcription factors also regulate the expression of epigenetic enzymes. Both transcription factors and epigenetic enzymes form a complex network that regulates the plasticity of macrophages. Here, we describe the latest knowledge concerning the potential epigenetic mechanisms that precisely regulate the biological function of macrophages and their effects on skin wound healing.

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Hypoxic ADSC-derived exosomes enhance wound healing in diabetic mice via delivery of circ-Snhg11 and induction of M2-like macrophage polarization

Cited by 61 publications

References 39 publications

The role of mesenchymal stem cell-derived EVs in diabetic wound healing

The role of mesenchymal stem cell-derived EVs in diabetic wound healing

Exosomal ncRNAs: The pivotal players in diabetic wound healing

Epigenetic regulation of macrophage polarization in wound healing

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