Hypoxia-treated umbilical mesenchymal stem cell alleviates spinal cord ischemia-reperfusion injury in SCI by circular RNA circOXNAD1/ miR-29a-3p/ FOXO3a axis

Wang, Xiujuan; Li, Wei; Hao, MingYuan; Yang, Ying; Xu, YongSheng

doi:10.1016/j.bbrep.2023.101458

Cited by 2 publications

(1 citation statement)

References 38 publications

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“…Exosomes derived from mesenchymal stem cells hold great promise for the treatment of SCI ( Liu W. Z. et al, 2021 ). Specifically, hypoxia-induced expression of exosomal circular RNA OXNAD1 (circOXNAD1), derived from human umbilical cord mesenchymal stem cells (HucMSCs), has been demonstrated to alleviate spinal cord ischemia–reperfusion injury in SCI through the circOXNAD1/miR-29a-3p/FOXO3a axis ( Wang X. et al, 2023 ). Moreover, bone marrow mesenchymal stem cells (BMSCs) have exhibited certain therapeutic effects on SCI ( Cofano et al, 2019 ), and BMSC-derived exosomes have been shown to improve recovery from SCI by alleviating inflammasome-associated sepsis by delivering circ_003564 ( Zhao Y. et al, 2022 ).…”

Section: The Roles Of Circrnas In Spinal Cord Injurymentioning

confidence: 99%

The roles of circular RNAs in nerve injury and repair

Zong,

Dai,

Yan

et al. 2024

Front. Mol. Neurosci.

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Nerve injuries significantly impact the quality of life for patients, with severe cases posing life-threatening risks. A comprehensive understanding of the pathophysiological mechanisms underlying nerve injury is crucial to the development of effective strategies to promote nerve regeneration. Circular RNAs (circRNAs), a recently characterized class of RNAs distinguished by their covalently closed-loop structures, have been shown to play an important role in various biological processes. Numerous studies have highlighted the pivotal role of circRNAs in nerve regeneration, identifying them as potential therapeutic targets. This review aims to succinctly outline the latest advances in the role of circRNAs related to nerve injury repair and the underlying mechanisms, including peripheral nerve injury, traumatic brain injury, spinal cord injury, and neuropathic pain. Finally, we discuss the potential applications of circRNAs in drug development and consider the potential directions for future research in this field to provide insights into circRNAs in nerve injury repair.

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Section: The Roles Of Circrnas In Spinal Cord Injurymentioning

confidence: 99%

The roles of circular RNAs in nerve injury and repair

Zong,

Dai,

Yan

et al. 2024

Front. Mol. Neurosci.

View full text Add to dashboard Cite

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Advances in application of hypoxia-preconditioned mesenchymal stem cell-derived exosomes

Zhuo,

Chen,

Zhao

2024

Front. Cell Dev. Biol.

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Mesenchymal stem cells (MSCs) primarily secrete physiologically functional exosomes via paracrine effects that act on various adjacent and distant cells, thus exerting their therapeutic effects. In recent years, hypoxic preconditioning, as a novel MSC culture mode, has emerged as a research hotspot. Many previous studies have shown the role and underlying regulatory mechanisms of hypoxic preconditioning in various diseases, which has provided sufficient reference materials for the MSC research field. Therefore, this review summarizes the progress in application of hypoxia-preconditioned MSC-derived exosomes that substantially increases and improves the biological activity of specific molecules, such as microRNA.

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Hypoxia-treated umbilical mesenchymal stem cell alleviates spinal cord ischemia-reperfusion injury in SCI by circular RNA circOXNAD1/ miR-29a-3p/ FOXO3a axis

Cited by 2 publications

References 38 publications

The roles of circular RNAs in nerve injury and repair

The roles of circular RNAs in nerve injury and repair

Advances in application of hypoxia-preconditioned mesenchymal stem cell-derived exosomes

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