2024
DOI: 10.3389/fcell.2024.1446050
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Advances in application of hypoxia-preconditioned mesenchymal stem cell-derived exosomes

Haitao Zhuo,
Yunfei Chen,
Guifang Zhao

Abstract: Mesenchymal stem cells (MSCs) primarily secrete physiologically functional exosomes via paracrine effects that act on various adjacent and distant cells, thus exerting their therapeutic effects. In recent years, hypoxic preconditioning, as a novel MSC culture mode, has emerged as a research hotspot. Many previous studies have shown the role and underlying regulatory mechanisms of hypoxic preconditioning in various diseases, which has provided sufficient reference materials for the MSC research field. Therefore… Show more

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