Hypoxia‐Responsive Photosensitizer Targeting Dual Organelles for Photodynamic Therapy of Tumors (Small 1/2023)

Tang, Yuqi; Wang, Xing; Zhu, Guanqun; Liu, Zhiyang; Chen, Xu‐Man; Bisoyi, Hari Krishna; Chen, Xiao; Chen, Xiaofei; Xu, Yiyi; Li, Juping; Li, Quan

doi:10.1002/smll.202370006

Cited by 5 publications

(4 citation statements)

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“…), which generates reactive oxygen radicals (ROS) that can kill tumor cells. [17][18][19][20] ROS, including singlet oxygen ( 1 O 2 ), peroxide (O 2…”

Section: Introductionmentioning

confidence: 99%

Recent advances in photo‐responsive carbon dots for tumor therapy

Zhang,

Liu,

2024

Responsive Materials

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The precision treatment of tumors with minimal side effects is associated with improved human health and quality of life. In recent years, phototherapy has attracted significant attention in tumor therapy due to its versatility, spatiotemporal controllability, non‐resistance, and minimal side effects. Carbon dots (CDs) are considered promising phototherapy reagents because of their simple preparation, facilitated surface modification, tunable energy bands, excellent electron‐transfer capabilities, remarkable photoelectric and photothermal conversion properties, and outstanding biocompatibility. This review summarizes recent advancements in photo‐responsive CDs for photodynamic therapy and the emerging photocatalytic therapy of tumors. Finally, the article discusses the main challenges associated with the development of photo‐responsive CDs for oncology therapeutics and strategies to overcome these challenges.

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“…), which generates reactive oxygen radicals (ROS) that can kill tumor cells. [17][18][19][20] ROS, including singlet oxygen ( 1 O 2 ), peroxide (O 2…”

Section: Introductionmentioning

confidence: 99%

Recent advances in photo‐responsive carbon dots for tumor therapy

Zhang,

Liu,

2024

Responsive Materials

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“…Various fluorescent nanomaterials, including quantum dots, carbon nanoparticles, and metal nanoparticles, have been developed for bacteria detection and sensing. [8][9][10][11][12][13] Metal-organic frameworks (MOFs) consist of metal ions (clusters) as nodes and organic ligands as linkers. Their high structure regularity, surface area, and porosity make them attractive candidates for diverse biological applications such as drug delivery, biocatalysts, and sensing.…”

Section: Introductionmentioning

confidence: 99%

A metal–organic framework-based fluorescence resonance energy transfer nanoprobe for highly selective detection of Staphylococcus Aureus

Qiao¹,

Chen²,

Xu³

et al. 2023

J. Mater. Chem. B

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“…Evidence showed that the biosynthesis efficiency of PpIX was positively correlated with the oxygen (O 2 ) concentration, because the rate-limiting enzyme coproporphyrinogen-III oxidase (CPOX) in the biosynthesis process of PpIX is oxygen-dependent. − Unfortunately, malignant cell proliferation and insufficient neovascularization result in tumor hypoxia, − which severely restricts the conversion of ALA to PpIX. Thus, the ROS production efficiency of PpIX is greatly limited in a hypoxic tumor environment. − O 2 in tumor cells is consumed by mitochondrial respiration through the oxidative phosphorylation (OXPHOS) metabolic pathway. − Consequently, inhibiting OXPHOS by targeting mitochondrial complexes in the mitochondrial electron transport chain (ETC) could economize endogenous O 2 and relieve tumor hypoxia. − However, the nonspecific distribution, rapid blood clearance, and poor solubility of the OXPHOS inhibitors resulted in poor improvement of tumor hypoxia.…”

Section: Introductionmentioning

confidence: 99%

Regulating Photosensitizer Metabolism with DNAzyme-Loaded Nanoparticles for Amplified Mitochondria-Targeting Photodynamic Immunotherapy

et al. 2023

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Mitochondria-specific photosensitizer accumulation is highly recommended for photodynamic therapy and mitochondrial DNA (mtDNA) oxidative damage-based innate immunotherapy but remains challenging. 5-Aminolevulinic acid (ALA), precursor of photosensitizer protoporphyrin IX (PpIX), can induce the exclusive biosynthesis of PpIX in mitochondria. Nevertheless, its photodynamic effect is limited by the intracellular biotransformation of ALA in tumors. Here, we report a photosensitizer metabolism-regulating strategy using ALA/DNAzyme-co-loaded nanoparticles (ALA&Dz@ZIF-PEG) for mitochondria-targeting photodynamic immunotherapy. The zeolitic imidazolate framework (ZIF-8) nanoparticles can be disassembled and release large amounts of zinc ions (Zn 2+ ) within tumor cells. Notably, Zn 2+ can relieve tumor hypoxia for promoting the conversion of ALA to PpIX. Moreover, Zn 2+ acts as a cofactor of rationally designed DNAzyme for silencing excessive ferrochelatase (FECH; which catalyzes PpIX into photoinactive Heme), cooperatively promoting the exclusive accumulation of PpIX in mitochondria via the "open source and reduced expenditure" manner. Subsequently, the photodynamic effects derived from PpIX lead to the damage and release of mtDNA and activate the innate immune response. In addition, the released Zn 2+ further enhances the mtDNA/cGAS-STING pathway mediated innate immunity. The ALA&Dz@ZIF-PEG system induced 3 times more PpIX accumulation than ALAloaded liposome, significantly enhancing tumor regression in xenograft tumor models.

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Hypoxia‐Responsive Photosensitizer Targeting Dual Organelles for Photodynamic Therapy of Tumors (Small 1/2023)

Cited by 5 publications

References 0 publications

Recent advances in photo‐responsive carbon dots for tumor therapy

Recent advances in photo‐responsive carbon dots for tumor therapy

A metal–organic framework-based fluorescence resonance energy transfer nanoprobe for highly selective detection of Staphylococcus Aureus

Regulating Photosensitizer Metabolism with DNAzyme-Loaded Nanoparticles for Amplified Mitochondria-Targeting Photodynamic Immunotherapy

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