Hypoxia–ischemia-mediated effects on neurodevelopmentally regulated cold-shock proteins in neonatal mice under strict temperature control

Jackson, T. L.; Herrmann, Janne Rothmar; Garman, Robert H.; Kang, Richard; Vagni, Vincent; Gorse, Kiersten; Janesko‐Feldman, Keri; Stezoski, Jason; Kochanek, Patrick M.

doi:10.1038/s41390-022-01990-4

Cited by 4 publications

(4 citation statements)

References 64 publications

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“…Thus, an age-related difference in this facet of CSR was seen at the cell level. We also found that RBM3 levels in brain decrease versus baseline in neonatal mice subjected to HI, under strict normothermia-suggesting an opportunity for hypothermia or drugs to increase RBM3 in vivo (41). The impact of manipulating RBM3 in vivo in models of HI remains to be fully characterized.…”

Section: Rbm3-preclinical Findingsmentioning

confidence: 82%

“…In addition, our studies in human male and female brain samples from the U.S. National Institutes of Health NeuroBioBank across age showed that baseline levels of RBM3 and the FGF21 coreceptor β-klotho are abundant in the hippocampus and in the prefrontal cortex in infants, present until ~2 years old, but negligible in the adult brain (30, 52). RBM3 and β-klotho are localized in neurons (52) and there are similar age-related differences in RBM3 in mice, suggesting conservation across species (41). When pregnant mice were subjected to cold stress, RBM3 expression was increased in the embryonic brain, and when RBM3 was knocked out, cold stress produced developmental brain defects (53).…”

Section: Age-related Differences In the Cold Stress Responsementioning

confidence: 99%

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Harnessing the Promise of the Cold Stress Response for Acute Brain Injury and Critical Illness in Infants and Children

Jackson,

Herrmann,

Fink

et al. 2023

Pediatric Critical Care Medicine

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Section: Rbm3-preclinical Findingsmentioning

confidence: 82%

Section: Age-related Differences In the Cold Stress Responsementioning

confidence: 99%

Harnessing the Promise of the Cold Stress Response for Acute Brain Injury and Critical Illness in Infants and Children

Jackson,

Herrmann,

Fink

et al. 2023

Pediatric Critical Care Medicine

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“…Preventing this temperature drop increases the magnitude of injury significantly 23 . RBM3 expression in human infants is high in the postnatal brain, and decreases as development progresses 24 , 25 . In rodents, RBM3 increases sharply after birth and remains high for the first two postnatal weeks 6 , 25 .…”

Section: Introductionmentioning

confidence: 99%

“…RBM3 expression in human infants is high in the postnatal brain, and decreases as development progresses 24 , 25 . In rodents, RBM3 increases sharply after birth and remains high for the first two postnatal weeks 6 , 25 . Despite high basal levels in the developing brain, the upregulation in response to hypothermia is larger in immature tissue than in more mature brain tissue 19 .…”

Section: Introductionmentioning

confidence: 99%

Hypothermia increases cold-inducible protein expression and improves cerebellar-dependent learning after hypoxia ischemia in the neonatal rat

et al. 2023

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Background: Hypoxic ischemic encephalopathy remains a significant cause of developmental disability 1 , 2 . The standard of care for term infants is hypothermia, which has multifactorial effects 3 – 5 . Therapeutic hypothermia upregulates the cold-inducible protein RNA binding motif 3 (RBM3) that is highly expressed in developing and proliferative regions of brain 6 , 7 . The neuroprotective effects of RBM3 in adult are mediated by its ability to promote translation of mRNAs such as reticulon 3 (RTN3) 8 . Methods: Hypoxia ischemia or control procedure was conducted in Sprague Dawley rat pups on postnatal day 10 (PND10). Pups were immediately assigned to normothermia or hypothermia at the end of the hypoxia. In adulthood, cerebellum-dependent learning was tested using the conditioned eyeblink reflex. The volume of the cerebellum and magnitude of cerebral injury were measured. A second study quantified RBM3 and RTN3 protein levels in the cerebellum and hippocampus collected during hypothermia. Results: Hypothermia reduced cerebral tissue loss and protected cerebellar volume. Hypothermia also improved learning of the conditioned eyeblink response. RBM3 and RTN3 protein expression were increased in the cerebellum and hippocampus of rat pups subjected to hypothermia on PND10. Conclusions: Hypothermia was neuroprotective in male and female pups and reversed subtle changes in the cerebellum after HI.

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RBM3 Promotes Anti-inflammatory Responses in Microglia and Serves as a Neuroprotective Target of Ischemic Stroke

Zhao,

Liu,

et al. 2024

Mol Neurobiol

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Hypoxia–ischemia-mediated effects on neurodevelopmentally regulated cold-shock proteins in neonatal mice under strict temperature control

Cited by 4 publications

References 64 publications

Harnessing the Promise of the Cold Stress Response for Acute Brain Injury and Critical Illness in Infants and Children

Harnessing the Promise of the Cold Stress Response for Acute Brain Injury and Critical Illness in Infants and Children

Hypothermia increases cold-inducible protein expression and improves cerebellar-dependent learning after hypoxia ischemia in the neonatal rat

RBM3 Promotes Anti-inflammatory Responses in Microglia and Serves as a Neuroprotective Target of Ischemic Stroke

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