Abstract:Background:
Hypoxic ischemic encephalopathy remains a significant cause of developmental disability
1
,
2
. The standard of care for term infants is hypothermia, which has multifactorial effects
3
–
5
. Therapeutic hypothermia upregulates the cold-inducible protein RNA binding motif 3 (RBM3) that is highly expressed in developing and proliferative regions of brain
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